Innowacje Molekularne dla Biomedycyny
Kierownik zespołu
Dr. M. T. Jeena
Tematyka badawcza
The team Molecular Innovations for Biomedical Interventions focus on the development of molecules of unconventional origin to address pressing biomedical challenges such as cancer, neurodegeneration, and aging-related disorders. These molecules will be designed to operate specifically inside the effected cells via aggregation, chemical reaction, self-organization, metal ion coordination etc. In addition, this team will contribute to establishing advanced bioimaging methodologies to simplify the existing experimental workflows to accelerate the advancement of basic research towards practical biomedical development. The strength of team’s conceptualization and methodology is the integration of multidisciplinary approaches at the interface of chemistry, material science, chemical biology and nanomedicine. This interdisciplinary approach enables to implement precisely engineered molecular systems into the living cells to address complex biological problems that cannot be tackled within the knowledge constrains of a single scientific discipline.
Członkowie
- PI: Dr. M. T. Jeena
- Ph.D. Candidate: Mr. Mikołaj Tkotz
Publikacje
19. Jeena, M. T., Link, J., Zhang, J., Harley, I., Turunen, P., Graf, R., Wagner, M., Baptista, L. A., Jonker, H. R. A., Cui, L., Lieberwirth I., Landfester, K., Rao, J., David, Y. W. N., Weil, T. Chaperone-derived copper (I)-binding peptide nanofibers disrupt copper homeostasis in cancer cells. Angew. Chem. Int. Ed. 2024, 63(51), e202412477., (doi.org/10.1002/anie.202412477).
18. Jeena, M. T., Jin, S., Jeong, K., Cho, Y., Kim, J. C., Lee, J. H., Lee, S., Hwang, S.-W., Kwak, S. K., Kim, S., Ryu, J, -H. Cancer-Selective Supramolecular chemotherapy by disassembly-assembly approach. Adv. Funct. Mater. 2022, 32, 2208098., (doi.org/10.1002/adfm.202208098).
17. Jeena, M. T., Jin, S., Jana, B., Ryu, J, -H. Enzyme-instructed morphology transformation of mitochondria-targeting peptide for the selective eradication of osteosarcoma. RSC Chem. Biol., 2022, 3, 1416-1421., (doi.org/10.1039/D2CB00166G).
16. Kim, S. J., Jeena, M. T., Kim, O. H., Choi, H. J., Lee, K. H., Hong, H.-E., Ryu, J. H. Application of self-assembly peptides targeting mitochondria as a novel treatment for sorafenib- resistant hepatocellular carcinoma cells. Sci. Rep. 2021, 874, 1-15., (doi.10.1038/s41598-020-79536-z).
15. Jin, S., Jeena, M. T., Jana, B., Moon, M., Choi, H., Lee, E., Ryu, J.-H. Spatiotemporal Self-Assembling Peptides Dictates Cancer-Selective Toxicity. Biomacromolecules, 2020, 12, 4806–4813., (doi.org/10.1021/acs.biomac.0c01000).
14. Kim, D. J., Jeena, M. T., Kim, O.-H., Hong, H.-E., Seo, H., Ryu, J.-H., Kim, S.-J. Novel Therapeutic Application of Self-Assembly Peptides Targeting the Mitochondria in In Vitro and In Vivo Experimental Models of Gastric Cancer. Int. J. of Mol. Sci. 2020, 21, 6126., (doi.10.3390/ijms21176126)
13. Jeena, M. T., Lee, S., Barui, A. K., Jin, S., Cho, Y., Hwang, S.-W., Kim, S., Ryu, J.-H. Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation of L-peptides. Chem. Commun, 2020, 56, 6265-6268., (doi.10.1039/D2CB00166G).
12. Jeena, M. T., Jeong, K., Go, E. M., Cho, Y., Lee, S., Jin, S., Hwang, S.-H., Jang, J. H., Kang, C. S., Bang, W.-Y., Lee, E., Kwak, S. K., Kim, S., Kim, S., Ryu, J, -H. Heterochiral Assembly of Amphiphilic Peptides Inside the Mitochondria for Supramolecular Cancer Therapeutics. ACS Nano, 2019, 10, 11022-11033., (doi.org/10.1021/acsnano.9b02522).
11. Park, H., Choi, Y., Jeena, M. T., Ahn, E., Choi, Y., Kang, M. -G., Lee, C. G., Kwon, T.-H., Rhee, H.-W., Ryu, J.-H., Kim, B.-S. Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteins. Macromol. Biosci. 2018, 18, 1700356., (doi.10.1021/acsanm.3c02824).
10. Kim, S., Palanikumar, L., Choi, H., Jeena, M. T., Kim, C., Ryu, J.-H. Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells. Chem. Sci. 2018, 9, 2474-2479., (doi. 10.1039/C7SC05189A)
9. Thomas, A. P., Palanikumar, L., Jeena, M.T., Kim, K., Ryu, J.-H. Cancer Mitochondria-Targeted Photodynamic Therapy with Supramolecular Assembly of HA and Near IR Cyanine Dye. Chem. Sci. 2017, 8, 8351., (doi.10.1039/c7sc03169f).
8. Jeena, M. T., Palanikumar, L., Go, E. M., Kim, I., Kang, M. G., Lee, S., Park, S., Choi, H., Kim, C.; Jin, S.-M., Bae, S. C., Rhee, H.-W., Lee, E., Kwak, S. K., Ryu, J.-H. Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction. Nat. Commun. 2017, 8, 26., (doi:10.1038/s41467-017-00047-z).
7. Palanikumar, L., Jeena, M. T., Kim, K., Oh, J. Y., Kim, C., Park, M.-H., Ryu, J.-H. Spatiotemporally and Sequentially Controlled Drug Release from Polymer Gatekeeper-Hollow silica Nanoparticles. Sci. Rep. 2017, 7, 46540., (doi.10.1038/srep46540).
6. Choi, H., Jeena, M.T., Palanikumar, L., Jeong, Y., Park, S., Lee, E., Ryu, J.-H. HA-incorporated nanostructure of peptide-drug amphiphile for targeted anticancer drug delivery. Chem. Commun. 2016, 52, 5637-5640., (doi.org/10.1039/C6CC00200E).
5. Jeena, M. T., Bok, T., Kim, S. H., Park, S., Kim, J.-U., Park, S. Ryu, J.-H. Siloxane incorporated copolymer as an in-situ cross-linkable binder for high performance silicon anode in Li-ion battery. Nanoscale, 2016, 8, 9245-9253., (doi.org/10.1039/C6NR01559J).
4. Palanikumar, L., Kim, H., Oh, J. Y., Thomas, A. P., Choi, E. S., Jeena, M. T., Joo, S. H., Ryu, J.-H. Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability. Biomacromolecules, 2015, 16, 2701-2714., (doi.org/10.1021/acs.biomac.5b00589).
3. Jeena, M. T., Lee, J.-I., Kim, S. H., Kim, C., Kim, J.-Y., Park, S. Ryu, J.-H. Multifunctional Molecular Design as an Efficient Polymeric Binder for Silicon Anodes in Lithium-Ion Batteries. ACS Appl. Mater. Interfaces, 2014, 6, 18001–18007., (doi.org/10.1021/am504854x).
2. Jeena, M. T., Choi, H., Ryu, J.-H. Bioactive Supramolecular Assembly of Peptide Amphiphiles to Control Cellular Fate. Soft Nanomaterial, 2019, 19, 27. (doi.10.1142/9789811201035_0002).
1. Jeena, M. T., Kim, S., Jin, S., Ryu, J.-H. Recent Progress in Mitochondria-Targeted Drug and Drug-Free Agents for Cancer Therapy. Cancers, 2020, 12(1), 2-20., (doi.10.3390/cancers12010004).