Wytwarzanie cyfrowe układów biomimetycznych
Kierownik zespołu
Dr hab. Marco Costantini, prof. Instytutu
Tematyka badawcza
Nasze zadania badawcze koncentrują się na odkrywaniu możliwości technik wytwarzania cyfrowego i wykorzystywaniu ich do tworzenia materiałów inspirowanych naturą. Zespół działa na styku chemii, biologii, inżynierii oraz materiałoznawstwa. Aktualnie nasze badania skupiają się na dwóch obszarach: i) wytwarzanie funkcjonalnych modeli tkanek/narządów przy wykorzystaniu technik biofabrykacji wspomaganych rozwiązaniami mikroprzepływowymi, ii) integracja narzędzi uczenia maszynowego do projektowania i wytwarzania innowacyjnych materiałów porowatych o bezprecedensowych właściwościach fizyko-chemicznych.




Członkowie
- dr hab. Marco Costantini - Kierownik zespołu
- dr Nehar Celikkin
- dr Piotr Ciąćka
- dr Anita Florkowska
- mgr Huma Jamil
- dr Fabio Maiullari
- dr Karol Makuch
- mgr Maede Pajouhande
- mgr Maryia Piletskaya
- dr Yurii Promovych
- mgr Saeed Rafieyan Boroujeni
- mgr Ahmad Shakeel
- mgr Władysław Sokołowski
- mgr Maria Celeste Tirelli
- mgr Abhishek Viswanath
- Justyna Gruszka - Koordynator zespołu
Publikacje
2025
Reggio Alessio, Fuoco Claudia, De Paolis Francesca, Deodati Rebecca, Testa Stefano, Celikkin Nehar, Volpi Marina, Bernardini Sergio, Fornetti Ersilia, Baldi Jacopo, Biagini Roberto, Seliktar Dror, Ciriłło Carmine, Swieszkowski Wojciech, Grumati Paolo, Cannata Stefano, Costantini Marco, Gargioli Cesare , 3D Rotary Wet-Spinning (RoWS) Biofabrication Directly Affects Proteomic Signature and Myogenic Maturation in Muscle Pericyte-Derived Human Myo-Substitute , AGGREGATE 2025
Maiullari Fabio, Ceraolo Maria Grazia, Presutti Dario, Fratini Nicole, Galbiati Matteo, Fasciani Alessandra, Giżyński Konrad, Bousselmi Salma, Megiorni Francesca, Marchese Cinzia, Kasprzycki Piotr, Karnowski Karol, Talone Alessandro, Varvaro Gaspare, Peddis Davide, Costantini Marco, Bearzi Claudia, Rizzi Roberto , Modeling breast cancer dynamics through modulable small Vessel Environment Bioreactor (sVEB) , BIOMATERIALS 2025
Maiullari Silvia, Mele Giada, Calandra Patrizia, di Blasio Giorgia, Valentini Sonia, Torcinaro Alessio, Manni Isabella, Teveroni Emanuela, Mancino Fabio, Proietti Luca, Maiullari Fabio, Pesavento Maria, Giorgini Ludovica, Putti Sabrina, Rizzi Roberto, Bortolani Sara, Scavizzi Ferdinando, Raspa Marcełło, Ricci Enzo, Piaggio Giulia, Gargioli Cesare, Pontecorvi Alfredo, Luvisetto Siro, Mazzone Massimiliano, Deidda Giancarlo, Moretti Fabiola , Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model , CELL DEATH AND DISEASE 2025
Chirivi Maila, Maiullari Fabio, Milan Marika, Ceraolo Maria Grazia, Fratini Nicole, Fasciani Alessandra, Bousselmi Salma, Stirm Michael, Scalera Francesca, Gervaso Francesca, Villa Michela, Vigano Raffaełło, Brambilla Francesca, Mauri Pierluigi, De Falco Elena, Di Silvestre Dario, Costantini Marco, Wolf Eckhard, Bearzi Claudia, Rizzi Roberto , Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel , ADVANCED HEALTHCARE MATERIALS 2025
Serpe Federico, Nalin Francesco, Tirelli Maria Celeste, Posabella Pasquale, Celikkin Nehar, Jaroszewicz Jakub, Swieszkowski Wojciech, Barbetta Andrea, Senturk Efsun, Casciola Carlo Massimo, Ruocco Giancarlo, Cidonio Gianluca, Scognamiglio Chiara, Costantini Marco , Microfluidic 3D Bioprinting of Foamed Fibers with Controlled Micromorphology , ACS APPLIED MATERIALS & INTERFACES 2025
Agarwal Tarun, Onesto Valentina, Banerjee Dishary, Guo Shengbo, Polini Alessandro, Vogt Caleb, Viswanath Abhishek, Esworthy Timothy, Cui Haitao, O'Donnell Aaron, Vajanthri Kiran Yellappa, Moroni Lorenzo, Ozbolat Ibrahim T., Panoskaltsis-Mortari Angela, Zhang Lijie Grace, Costantini Marco, Maiti Tapas Kumar , 3D bioprinting in tissue engineering: current state-of-the-art and challenges towards system standardization and clinical translation , BIOFABRICATION 2025
Galbiati Matteo, Maiullari Fabio, Ceraolo Maria Grazia, Bousselmi Salma, Fratini Nicole, Gega Klajdi, Recchia Sandro, Ferretti Anna Maria, Scala Giovanni, Costantini Marco, Sciarra Tommaso, Rizzi Roberto, Bearzi Claudia , Bioactive Hydrogel Supplemented with Stromal Cell-Derived Extracellular Vesicles Enhance Wound Healing , PHARMACEUTICS 2025
Costantini Marco, Cognini Flavio, Angelini Roberta, Alfano Sara, Villano Marianna, Martinelli Andrea, Bolzonella David, Rossi Marco, Barbetta Andrea , Study of the Interplay Among Melt Morphology, Rheology and 3D Printability of Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Blends , JOURNAL OF FUNCTIONAL BIOMATERIALS 2025
Ceraolo Maria Grazia, Milan Marika, Fratini Nicole, Vigano Raffaełło, Bousselmi Salma, Soluri Andrea, Pesce Elisa, Mauri Pier Luigi, Ciuffreda Giusy, Landoni Elisa, Brambilla Francesca, Dotti Gianpietro, Di Silvestre Dario, Maiullari Fabio, Bearzi Claudia, Rizzi Roberto , CSPG4.CAR-T Cells Modulate Extracellular Matrix Remodeling in DMD Cardiomyopathy , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2025
Ahmad Shakeel, Foik Ilona P., Jankowski Paweł, Samborski Adam, Vasantham Shreyas K., Garstecki Piotr , Ciprofloxacin pre-exposure influences individual cell MIC and heteroresistance of bacteria inside microfluidic droplets , SCIENTIFIC REPORTS 2025
Shahryari Shahab, Ahmad Shakeel, Foik Ilona Paulina, Jankowski Paweł, Samborski Adam, Równicki Marcin, Vasantham Shreyas Kandhadai, Garstecki Piotr , Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach , ROYAL SOCIETY OPEN SCIENCE 2025
2024
Weber Philipp; Cai Ling; Rojas Francisco Javier Aguilar; Garciamendez-Mijares Carlos Ezio; Tirelli Maria Celeste; Nalin Francesco; Jaroszewicz Jakub; Swieszkowski Wojciech; Costantini Marco; Zhang Yu Shrike , Microfluidic bubble-generator enables digital light processing 3D printing of porous structures , AGGREGATE , 2024, 5, 1, e409
Marina Volpi, Alessia Paradiso, Ewa Walejewska, Cesare Gargioli, Marco Costantini, Wojciech Swieszkowski , Automated Microfluidics‐Assisted Hydrogel‐Based Wet‐Spinning for the Biofabrication of Biomimetic Engineered Myotendinous Junction , ADVANCED HEALTHCARE MATERIALS , 2024, "13, 32, 2402075"
Paradiso Alessia; Volpi Marina; Martinez Diana C.; Jaroszewicz Jakub; Costantini Marco; Swieszkowski Wojciech , Engineering Biomimetic Microvascular Capillary Networks in Hydrogel Fibrous Scaffolds via Microfluidics-Assisted Co-Axial Wet-Spinning , ACS APPLIED MATERIALS & INTERFACES , 2024, 16, 48, 65927- 65941
Maiullari Fabio; Milan Marika; Chirivi Maila; Ceraolo Maria Grazia; Bousselmi Salma; Fratini Nicole; Galbiati Matteo; Fortunato Orazio; Costantini Marco; Brambilla Francesca; Mauri Pierluigi; Di Silvestre Dario; Calogero Antonella; Sciarra Tommaso; Rizzi Roberto; Bearzi Claudia , Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs , BIOFABRICATION , 2024, 16, 4, 45009
Posabella Pasquale; Heljak Marcin; Costantini Marco; Swieszkowski Wojciech , Spherical-based porous architectures: In silico design and validation , INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES , 2024, 283, 109636
Rangam Neha Venkatesh; Ahmad Shakeel; Koronkiewicz Roksana; Foik Ilona Paulina; Borowicz Paweł; Wiśniewska Agnieszka; Hołdyński Marcin; Toth Jozsef; Kover Laszlo; Roszko Marek Łukasz; Lesiak-Orlowska Beata; Sudagar Alcina Johnson , Bactericidal efficiency of silver nanocomposites obtained using Brewer's spent grains , APPLIED SURFACE SCIENCE , 2024, 661, 159958
Francesco Nalin Maria Celeste Tirelli Piotr Garstecki Witold Postek Marco Costantini , Tuna-step: tunable parallelized step emulsification for the generation of droplets with dynamic volume control to 3D print functionally graded porous materials , LAB ON A CHIP , 2024, 24 (1), 113-126
2023
Van Ombergen Angelique; Chalupa-Gantner Franziska; Chansoria Parth; Colosimo Bianca Maria; Costantini Marco; Domingos Marco; Dufour Alexandre; De Maria Carmelo; Groll Juergen; Jungst Tomasz; Levato Riccardo; Malda Jos; Margarita Alessandro; Marquette Christophe; Ovsianikov Aleksandr; Petiot Emma; Read Sophia; Surdo Leonardo; Świeszkowski Wojciech; Vozzi Giovanni; Windisch Johannes; Zenobi-Wong Marcy; Gelinsky Michael
3D Bioprinting in Microgravity: Opportunities Challenges and Possible Applications in Space
ADVANCED HEALTHCARE MATERIALS 2023 12 23
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Celikkin Nehar; Presutti Dario; Maiullari Fabio; Volpi Marina; Promovych Yurii; Gizyński Konrad; Dolińska Joanna; Wiśniewska Agnieszka; Opałło Marcin; Paradiso Alessia; Rinoldi Chiara; Fuoco Claudia; Swieszkowski Wojciech; Bearzi Claudia; Rizzi Roberto; Gargioli Cesare; Costantini Marco
Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for the in vitro production of functional myo-substitutes
BIOFABRICATION 2023 15 4 45012
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Agarwal Tarun; Chiesa Irene; Costantini Marco; Lopamarda Anna; Tirelli Maria Celeste; Borra Om Prakash; Varshapally Subhash Venkata Sai; Kumar Yanamadala Ashwin Vijay; Reddy G. Koteswara; De Maria Carmelo; Zhang Lijie Grace; Maiti Tapas Kumar
Chitosan and its derivatives in 3D/4D (bio) printing for tissue engineering and drug delivery applications
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2023 246 125669
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Marcotulli Martina; Tirelli Maria Celeste; Volpi Marina; Jaroszewicz Jakub; Scognamiglio Chiara; Kasprzycki Piotr; Karnowski Karol; Swieszkowski Wojciech; Ruocco Giancarlo; Costantini Marco; Cidonio Gianluca; Barbetta Andrea
Microfluidic 3D Printing of Emulsion Ink for Engineering Porous Functionally Graded Materials
ADVANCED MATERIALS TECHNOLOGIES 2023 8 5
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Paradiso Alessia; Volpi Marina; Rinoldi Chiara; Celikkin Nehar; Negrini Nicola Contessi; Bilgen Muge; Dallera Giorgio; Pierini Filippo; Costantini Marco; Świeszkowski Wojciech; Fare Silvia
In vitro functional models for human liver diseases and drug screening: beyond animal testing
BIOMATERIALS SCIENCE 2023 11 9 2988-3015
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Nalin Francesco; Tirelli Maria Celeste; Garstecki Piotr; Postek Witold; Costantini Marco
Tuna-step: tunable parallelized step emulsification for the generation of droplets with dynamic volume control to 3D print functionally graded porous materials
LAB ON A CHIP 2023 24 1 113-126
2022
Wang, D., Liu, J., Presutti, D., Agarwal, T., Zarepour, A., Celikkin, N., Hooshmand, S., Nayak, C., Ghomi, M., Zarrabi, A., Costantini, M., Behera, B., & Kumar Maiti, T.
Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications.
Materials, https://doi.org/10.3390/MA15010337
Volpi, M., Paradiso, A., Costantini, M., & Święszkowski, W.
Hydrogel-Based Fiber Biofabrication Techniques for Skeletal Muscle Tissue Engineering.
ACS Biomaterials Science & Engineering, https://doi.org/10.1021/ACSBIOMATERIALS.1C01145
Guzowski, J., Buda, R. J., Costantini, M., Ćwiklińska, M., Garstecki, P., & Stone, H. A.
From dynamic self-organization to avalanching instabilities in soft-granular threads.
Soft Matter, https://doi.org/10.1039/D1SM01350E
Celikkin, N., Mastrogiacomo, S., Dou, W., Heerschap, A., Oosterwijk, E., Walboomers, X. F., & Święszkowski, W.
In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications.
Journal of Biomedical Materials Research Part B: Applied Biomaterials, https://doi.org/10.1002/JBM.B.35067
Malik, G., Agarwal, T., Costantini, M., Pal, S., & Kumar, A.
Oxygenation therapies for improved wound healing: Current trends and technologies.
J. Mater. Chem. B., https://doi.org/10.1039/D2TB01498J
Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Negrini, N. C., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Swieszkowski, W., & Fare’, S.
In vitro functional models for human liver diseases and drug screening: beyond animal testing.
Biomaterials Science, https://doi.org/10.1039/D1BM01872H
Marcotulli, M., Tirelli, M. C., Volpi, M., Jaroszewicz, J., Scognamiglio, C., Kasprzycki, P., Karnowski, K., Święszkowski, W., Ruocco, G., Costantini, M., Cidonio, G., Barbetta, A.
Microfluidic 3D Printing of Emulsion Ink for Engineering Porous Functionally Graded Materials.
Advanced Materials Technologies, https://doi.org/10.1002/ADMT.202201244
