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The primary objective of the project is to develop the first Stimulated Raman Scattering (SRS) microscopic-microfluidic system for non-invasive imaging of live cells and apply it to rapid leukemia cell imaging, diagnostics, sorting and assessment of chemosensitivity in vitro. Multidisciplinary teams of experts establishing the consortium will characterize Raman spectra of leukemic cells and link them to biological features of the disease. These data will be thereafter used to design and construct, microfluidic-based diagnostic device utilizing SRS microscopy which will allow for quick and reliable differentiation between different types of leukemia cells providing clinicians with quantitative information crucial to make proper decisions during the course of the treatment. The envisaged microfluidic-SRS instrument will fill the gap in the current diagnostic methodology of leukemia, accelerate diagnostics and decrease its cost. Moreover, the developed methodology will open new areas of application in leukemia research.

We are looking for a motivated and experienced technician with background in microfabrication of thermoplastics (polycarbonate, PMMA) using CNC micro milling and/or microfabrication using photolithography and soft lithography techniques. Knowledge in designing and fabrication of microfluidics devices is a valuable asset. The successful candidate will join an international and multidisciplinary team and will be responsible for designing and fabrication of microfluidic devices and custom parts necessary for integration of microfluidic devices with the SRS microscope.

• Designing and fabrication microfluidic devices and their parts (holders, connection ports, etc.) in hard polymers (polycarbonate, PMMA) and fluoropolymers using a CNC machine
• Maintenance of the CNC machine
• Designing and fabrication of custom mechanical and opto-mechanical elements necessary for integration of microfluidic devices with the SRS microscope.
• Cooperation with the members of the group including English speaking personnel
• Designing and fabrication of microfluidic master moulds with UV lithography and microfluidic devices using soft lithography.

• Employment on 50 % time basis (for 9,5 months) with full remuneration cost (brutto-brutto) of 5000 PLN per month financed by the Foundation for Polish Science Team-NET project No. POIR.04.04.00-00-16ED/18.
• Work in the outstanding scientific institution in the dynamic research group with members representing diverse interests and qualifications – see details on the website: http://micof.pl/en
• Possibility to collaborate with research groups engaged in the project (University of Warsaw, Medical University of Lodz, Institute of Haematology and Transfusion Medicine, Jagellonian University) and industrial partners (Electric System & Laser Technology).
• Scientific and organizational support
• Access to the modern research equipment.

• MSc. or Eng. in engineering, machine design, physics/mechanics, electronics, informatics or similar
• Solid knowledge and hands-on experience with software AutoCad, MasterCam, Mach3
• Knowledge of technical drawing
• Ability to use measuring tools
• Knowledge of machining issues
• Creativity, analytical thinking, technical troubleshooting and critical problem-solving skills
• Experience in photolithography and/or other microfabrication techniques and in microfluidic design and chip fabrication will be considered as a valuable asset
• Excellent communications, organization and time management skills
• Fluent in spoken and written English
• Flexibility and ability to work in a multidisciplinary and multicultural research team

Evaluation of the applications will be in 2 stages:

1. First stage: analysis of CV, ML and the other submitted documents
2. Second stage: interview (only the highest scoring candidates will be invited). The interviews are scheduled for the 10th of February, 2023.