Microfluidics and Complex Fluids Research Group

Research group no. 11

Microfluidics and Complex Fluids Research Group

Group leader

prof. dr hab. Piotr Garstecki

+48 22 343 2233

microfluidics@ichf.edu.pl

Research topics

Team 11 carries out research on microfluidic techniques used in chemistry, biochemistry, and microbiology. At the core of our scientific interests are two-phase flows, i.e. micro-scale fluid flows which don’t mix together. Through manipulation of these immiscible flows, we can very rapidly establish optimal conditions for chemical synthesis, determine antibiotic susceptibility of bacteria, and examine the evolution of bacteria under different chemical conditions. We also create solutions for medical diagnostics.

Members

  • mgr Shakeel Ahmad
  • dr Ladislav Derzsi 
  • dr Ilona Foik
  • mgr Justyna Gruszka
  • dr inż. Paweł Jankowski
  • mgr inż. Łukasz Kozoń
  • mgr Francesco Nalin 
  • dr Dominika Ogończyk 
  • dr Yurii Promovych 
  • dr Adam Samborski
  • mgr Shreyas Vasantham
  • dr Chirantan Das
See external website

Publications

2021

Krainer, G., Welsh, T. J., Joseph, J. A., Espinosa, J. R., Wittmann, S., de Csilléry, E., Sridhar, A., Toprakcioglu, Z., Gudiškytė, G., Czekalska, M. A., Arter, W. E., Guillén-Boixet, J., Franzmann, T. M., Qamar, S., George-Hyslop, P. S., Hyman, A. A., Collepardo-Guevara, R., Alberti, S., & Knowles, T. P. J.
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
Nature Communications, https://doi.org/10.1038/s41467-021-21181-9

Czekalska, M. A., Jacobs, A. M. J., Toprakcioglu, Z., Kong, L., Baumann, K. N., Gang, H., Zubaite, G., Ye, R., Mu, B., Levin, A., Huck, W. T. S., & Knowles, T. P. J.
One-Step Generation of Multisomes from Lipid-Stabilized Double Emulsions.
ACS Applied Materials & Interfaces, https://doi.org/10.1021/acsami.0c16019

2022

Postek, W., & Garstecki, P.
Droplet Microfluidics for High-Throughput Analysis of Antibiotic Susceptibility in Bacterial Cells and Populations.
Accounts of Chemical Research,  https://doi.org/10.1021/ACS.ACCOUNTS.1C00729

Guzowski, J., Buda, R. J., Costantini, M., Ćwiklińska, M., Garstecki, P., & Stone, H. A.
From dynamic self-organization to avalanching instabilities in soft-granular threads.
Soft Matter, https://doi.org/10.1039/D1SM01350E

Kao, Y.-T., Calabrese, S., Borst, N., Lehnert, M., Lai, Y.-K., Schlenker, F., Juelg, P., Zengerle, R., Garstecki, P., & von Stetten, F.
Microfluidic One-Pot Digital Droplet FISH Using LNA/DNA Molecular Beacons for Bacteria Detection and Absolute Quantification.
Biosensors, https://doi.org/10.3390/BIOS12040237

Lai, Y.-K., Opalski, A. S., Garstecki, P., Derzsi, L., & Guzowski, J.
A double-step emulsification device for direct generation of double emulsions.
Soft Matter. https://doi.org/10.1039/D2SM00327A

Ruszczak, A., Bartkova, S., Zapotoczna, M., Scheler, O., & Garstecki, P.

Droplet-based methods for tackling antimicrobial resistance.

Current Opinion in Biotechnology, https://doi.org/10.1016/J.COPBIO.2022.102755

Postek, W., Pacocha, N., & Garstecki, P.
Microfluidics for antibiotic susceptibility testing.
Lab on a Chip, https://doi.org/10.1039/D2LC00394E

Samborski, A., Jankowski, P., & Ostaszewski, R.
The influence of UV light on the course of fluorescent enzyme assays.
Preparative Biochemistry & Biotechnology, https://doi.org/10.1080/10826068.2022.2119573

Pacocha, N., Zapotoczna, M., Makuch, K., Boguslawski, J., & Garstecki, P.
You will know by its tail: a method for quantification of heterogeneity of bacterial populations using single-cell MIC profiling.
Lab on a Chip, https://doi.org/10.1039/D2LC00234E

Duran, M., Serrano, A., Nikulin, A., Dauvergne, J.-L., Derzsi, L., & Palomo del Barrio, E.
Microcapsule production by droplet microfluidics: A review from the material science approach.
Materials & Design,  https://doi.org/10.1016/J.MATDES.2022.111230

Kumari, J, Sah, R. K., Mohaideen, N., M., Shakeel, A., Pati, S., & Singh, S.
Studying the Rationale of Fire Ant Sting Therapy Usage by the Tribal Natives of Bastar Revealed Ant Venom-Derived Peptides with Promising Anti-Malarial Activity.
Toxins, https://doi.org/10.3390/TOXINS14110789

2023

Ruszczak, A., Jankowski, P., Vasantham, S. K., Scheler, O., & Garstecki, P.
Physicochemical Properties Predict Retention of Antibiotics in Water-in-Oil Droplets.
Analytical Chemistry, https://doi.org/10.1021/ACS.ANALCHEM.2C04644

See also