Offer no. 11/17

A new bisbithiophene oligonucleotide analog with CGCCGCCG sequence and its method of preparation, an electrochemical sensor with this analog, measurements with this sensor as well as its application

  • Summary:

    The invention relates to an artificial DNA analog, CGCCGCCG (C–cytosine, G–guanine) and preparation methods of this analog in molecularly imprinted polymer, obtained by potentiodynamically electropolymerization, on the conductive surface.  Invention relates also to application of chemosensor with its recognition film as well as application of this analog for selective detection and determination of the GCGGCGGC oligonucleotide.

  • Inventors:
    Katarzyna Bartołd, Agnieszka Pietrzyk-Le, Karolina Gołębiewska, Wojciech Lisowski, Silvia Cauteruccio, Emanuela Licandro, Francis D’Souza, Włodzimierz Kutner
  • Advantages / Innovative aspects:
    • Devised DNA analog is easy to obtain in the form of stable and chemically resistant thin polymer films,
    • It can be deposited on the substrates with variety of shapes, 
    • It allows for selective and reversible binding of GCGGCGGC oligonucleotide,
    • Chemosensor with recognition layer from this polymer exhibits high selectivity and high sensitivity towards GCGGCGGC oligonucleotide, as well as appreciable detection limit.
  • Keywords:
    DNA analoges, molecularly imprinted polymer, GCGGCGGC
  • Field:
  • Usage:
    • Biosensors
    • Analytical chemistry
    • Sensors
    • Chemosensors for determination in biological samples
    • DNA probes
  • State of the progress:
    stage of research
  • Intellectual property rights:
    Patent application in Poland
  • Publication URL:


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