Offer no. 10/17

Molecularly imprinted polymer with embedded redox probe and counter ion salt; label-free electrochemical chemosensor for determination of chosen analites with self-reporting molecularly imprinted film recognition unit

  • Summary:

    The present invention reveals a molecularly imprinted polymer (MIP) with a covalently integrated redox probe, a label-free selective  electrochemical sensor with a self reporting molecularly imprinted polymer film as a recognition unit, and a new monomer constituting p-[bis(2,2'-bithien-5-yl)methyl]ferrocenebenzene, and the method of this monomer preparation.

    According to the present invention, a  labell-free electrochemical sensor has been developed and manufactured with a redox probe embedded within the MIP. It has been shown that the presence of counterions (anions) capable of neutralizing the positive electrical charge generated by the electro-oxidation of ferrocene substituents is necessary for the proper functioning of this sensor. Two MIP-chemosensors with a built-in redox probe and two different counterions, i.e., built-in or by physical entrapment of the large lipophilic counterion salt inside the MIP film, or by copolymerisation of the salt of such counterion with the functional and cross-linker monomer, were produced

  • Inventors:
    Patrycja Łach, Maciej Cieplak, Marta Sosnowska, Piyush S. Sharma, Raghu Chitta, Francis D'Souza, Włodzimierz Kutner
  • Advantages / Innovative aspects:

    The developed label-free electrochemical chemosensor, with self-reporting MIP recognition unit, enables electrochemical (CV, DPV) determination of non-electroactive analytes without the need to add an external redox probe

  • Keywords:
    Molecularly imprinted polymers, electrochemical chemosensors, self-reporting materials
  • Field:
  • Usage:

    Combining the selective recognition within the MIP film along with the immobilization of the redox probe enables development of a whole range of selective, portable chemosensors for the determination of a various compounds

  • State of the progress:
    stage of research
  • Intellectual property rights:
    Patent application in Poland
Back to patents list