Digital manufacturing of biomimetic systems
Group leader
Dr hab. Marco Costantini, prof. instytutu
Research topics
The core research activities of the group consist in exploring the landscape of digital manufacturing technologies and exploit them to manufacture materials inspired by nature. The group operates at the convergence of chemistry, biology, engineering, and materials science. Currently, our research is focused on two research lines: i) one devoted to the generation of functional models of tissues/organs using microfluidic-assisted biofabrication approaches, and ii) the other focused on integrating machine learning tools in the design and fabrication process of innovative porous materials with unprecedented physico-chemical properties.
Members
- Associate Professor Marco Costantini (Group leader)
- Justyna Gruszka (Research Group Coordinator)
- Dr. Nehar Celikkin
- Dr. Yurii Promovych
- Dr. Fabio Maiullari
- Dr. Anita Florkowska
- Maede Pajouhande, PhD Student
- Maryia Piletskaya, PhD Student
- Maria Celeste Tirelli, PhD Student
- Abhishek Viswanath, PhD Student
- Ahmad Shakeel, PhD Student
Publications
2024
Weber Philipp; Cai Ling; Rojas Francisco Javier Aguilar; Garciamendez-Mijares Carlos Ezio; Tirelli Maria Celeste; Nalin Francesco; Jaroszewicz Jakub; Swieszkowski Wojciech; Costantini Marco; Zhang Yu Shrike , Microfluidic bubble-generator enables digital light processing 3D printing of porous structures , AGGREGATE , 2024, 5, 1, e409
Marina Volpi Alessia Paradiso Ewa Walejewska Cesare Gargioli Marco Costantini Wojciech Swieszkowski , Automated Microfluidics‐Assisted Hydrogel‐Based Wet‐Spinning for the Biofabrication of Biomimetic Engineered Myotendinous Junction , ADVANCED HEALTHCARE MATERIALS , 2024, "13, 32, 2402075"
Paradiso Alessia; Volpi Marina; Martinez Diana C.; Jaroszewicz Jakub; Costantini Marco; Swieszkowski Wojciech , Engineering Biomimetic Microvascular Capillary Networks in Hydrogel Fibrous Scaffolds via Microfluidics-Assisted Co-Axial Wet-Spinning , ACS APPLIED MATERIALS & INTERFACES , 2024, 16, 48, 65927- 65941
Maiullari Fabio; Milan Marika; Chirivi Maila; Ceraolo Maria Grazia; Bousselmi Salma; Fratini Nicole; Galbiati Matteo; Fortunato Orazio; Costantini Marco; Brambilla Francesca; Mauri Pierluigi; Di Silvestre Dario; Calogero Antonella; Sciarra Tommaso; Rizzi Roberto; Bearzi Claudia , Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs , BIOFABRICATION , 2024, 16, 4, 45009
Posabella Pasquale; Heljak Marcin; Costantini Marco; Swieszkowski Wojciech , Spherical-based porous architectures: In silico design and validation , INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES , 2024, 283, 109636
Rangam Neha Venkatesh; Ahmad Shakeel; Koronkiewicz Roksana; Foik Ilona Paulina; Borowicz Paweł; Wiśniewska Agnieszka; Hołdyński Marcin; Toth Jozsef; Kover Laszlo; Roszko Marek Łukasz; Lesiak-Orlowska Beata; Sudagar Alcina Johnson , Bactericidal efficiency of silver nanocomposites obtained using Brewer's spent grains , APPLIED SURFACE SCIENCE , 2024, 661, 159958
Francesco Nalin Maria Celeste Tirelli Piotr Garstecki Witold Postek Marco Costantini , Tuna-step: tunable parallelized step emulsification for the generation of droplets with dynamic volume control to 3D print functionally graded porous materials , LAB ON A CHIP , 2024, 24 (1), 113-126
2023
Van Ombergen Angelique; Chalupa-Gantner Franziska; Chansoria Parth; Colosimo Bianca Maria; Costantini Marco; Domingos Marco; Dufour Alexandre; De Maria Carmelo; Groll Juergen; Jungst Tomasz; Levato Riccardo; Malda Jos; Margarita Alessandro; Marquette Christophe; Ovsianikov Aleksandr; Petiot Emma; Read Sophia; Surdo Leonardo; Świeszkowski Wojciech; Vozzi Giovanni; Windisch Johannes; Zenobi-Wong Marcy; Gelinsky Michael
3D Bioprinting in Microgravity: Opportunities Challenges and Possible Applications in Space
ADVANCED HEALTHCARE MATERIALS 2023 12 23
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Celikkin Nehar; Presutti Dario; Maiullari Fabio; Volpi Marina; Promovych Yurii; Gizyński Konrad; Dolińska Joanna; Wiśniewska Agnieszka; Opałło Marcin; Paradiso Alessia; Rinoldi Chiara; Fuoco Claudia; Swieszkowski Wojciech; Bearzi Claudia; Rizzi Roberto; Gargioli Cesare; Costantini Marco
Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for the in vitro production of functional myo-substitutes
BIOFABRICATION 2023 15 4 45012
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Agarwal Tarun; Chiesa Irene; Costantini Marco; Lopamarda Anna; Tirelli Maria Celeste; Borra Om Prakash; Varshapally Subhash Venkata Sai; Kumar Yanamadala Ashwin Vijay; Reddy G. Koteswara; De Maria Carmelo; Zhang Lijie Grace; Maiti Tapas Kumar
Chitosan and its derivatives in 3D/4D (bio) printing for tissue engineering and drug delivery applications
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2023 246 125669
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Marcotulli Martina; Tirelli Maria Celeste; Volpi Marina; Jaroszewicz Jakub; Scognamiglio Chiara; Kasprzycki Piotr; Karnowski Karol; Swieszkowski Wojciech; Ruocco Giancarlo; Costantini Marco; Cidonio Gianluca; Barbetta Andrea
Microfluidic 3D Printing of Emulsion Ink for Engineering Porous Functionally Graded Materials
ADVANCED MATERIALS TECHNOLOGIES 2023 8 5
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Paradiso Alessia; Volpi Marina; Rinoldi Chiara; Celikkin Nehar; Negrini Nicola Contessi; Bilgen Muge; Dallera Giorgio; Pierini Filippo; Costantini Marco; Swieszkowski Wojciech; Fare Silvia
In vitro functional models for human liver diseases and drug screening: beyond animal testing
BIOMATERIALS SCIENCE 2023 11 9 2988-3015
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Nalin Francesco; Tirelli Maria Celeste; Garstecki Piotr; Postek Witold; Costantini Marco
Tuna-step: tunable parallelized step emulsification for the generation of droplets with dynamic volume control to 3D print functionally graded porous materials
LAB ON A CHIP 2023 24 1 113-126
2022
Wang, D., Liu, J., Presutti, D., Agarwal, T., Zarepour, A., Celikkin, N., Hooshmand, S., Nayak, C., Ghomi, M., Zarrabi, A., Costantini, M., Behera, B., & Kumar Maiti, T.
Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications.
Materials, https://doi.org/10.3390/MA15010337
Volpi, M., Paradiso, A., Costantini, M., & Święszkowski, W.
Hydrogel-Based Fiber Biofabrication Techniques for Skeletal Muscle Tissue Engineering.
ACS Biomaterials Science & Engineering, https://doi.org/10.1021/ACSBIOMATERIALS.1C01145
Guzowski, J., Buda, R. J., Costantini, M., Ćwiklińska, M., Garstecki, P., & Stone, H. A.
From dynamic self-organization to avalanching instabilities in soft-granular threads.
Soft Matter, https://doi.org/10.1039/D1SM01350E
Celikkin, N., Mastrogiacomo, S., Dou, W., Heerschap, A., Oosterwijk, E., Walboomers, X. F., & Święszkowski, W.
In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications.
Journal of Biomedical Materials Research Part B: Applied Biomaterials, https://doi.org/10.1002/JBM.B.35067
Malik, G., Agarwal, T., Costantini, M., Pal, S., & Kumar, A.
Oxygenation therapies for improved wound healing: Current trends and technologies.
J. Mater. Chem. B., https://doi.org/10.1039/D2TB01498J
Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Negrini, N. C., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Swieszkowski, W., & Fare’, S.
In vitro functional models for human liver diseases and drug screening: beyond animal testing.
Biomaterials Science, https://doi.org/10.1039/D1BM01872H
Marcotulli, M., Tirelli, M. C., Volpi, M., Jaroszewicz, J., Scognamiglio, C., Kasprzycki, P., Karnowski, K., Święszkowski, W., Ruocco, G., Costantini, M., Cidonio, G., Barbetta, A.
Microfluidic 3D Printing of Emulsion Ink for Engineering Porous Functionally Graded Materials.
Advanced Materials Technologies, https://doi.org/10.1002/ADMT.202201244