Institute of Physical Chemistry Polish Academy of Sciences, Soft Condensed Matter Group
National Science Centre
Project title, type and project number
High throughput microfluidic system for fast determination of the equilibrium constant for biomolecular complexes: application to RNA-DNA interactions, NCN PRELUDIUM BIS 2 no. 2020/39/O/ST4/00877, 22/2021
prof. dr hab. Robert Hołyst
This project will develop a high throughput microfluidics-based device for the quantitative characterization of biochemical reactions using fluorescence-based methods. We intend that this improvement paves a way towards the quantitative study of biomolecule interactions in living systems and preliminary research after discovering new pharmaceuticals. Subsequently, we will use a newly developed device to quantify the stability of 20 base-pair DNA-RNA oligonucleotides with differently located multiple mismatches in various environmental conditions, such as ions concentration, pH, and temperature. As well, we will measure interactions between double-strand DNA and single-strand RNA.
We are looking for an experimentalist with strong theoretical background in chemistry to cope with the physico-chemical problems in physical chemistry. We guarantee access to top-notch instrumentation and well equipped laboratories.
Number of vacancies
Key responsibilities include
1. Construction and testing of the microfluidics high-throughput devices for analysis of biochemical reaction.
2. Analysis of RNA-DNA complex formation for strands with
3. Preparation of the Ph.D. thesis
Position in the project
PhD student – scholarship position
We offer 5 000 PLN per month stipend to the month in which the midterm evaluation of the doctoral student at the doctoral school is carried out and 6 000 PLN thereafter subject to successful mid-term evaluation.
Position starts on
Maximum planned period of contract/stipend agreement
We offer 5 000 PLN per month stipend to the month in which the midterm evaluation of the doctoral student at the doctoral school is carried out and 6 000 PLN thereafter subject to successful mid-term evaluation. The stipendship is for 48 months.
Career development prospects at IPC PAS
The successful candidate will be part of a Soft Condensed Matter Group. Funds are allocated to cover participation in international conferences and for five months fellowship at the Radboud University (Netherlands). PhD student is obliged to apply for funding for six months fellowship at the Radboud University (Netherlands) in the competition carried out by the Polish National Agency for Academic Exchange (NAWA) during his/her doctoral period at Doctoral school.
Institute provides opportunity to participate in ERASMUS + programme.
Link to Euraxess websitesee website
More detailssee website
Chemistry, Physical Chemistry
Scientific profile of a candidate
First Stage Researcher (R1)
1. Education: Master degree of Chemistry or related discipline.
2. Good knowledge of English.
3. Strong motivation and commitment.
4. Knowledge of the FCS technique (Fluorescence Correlation Spectroscopy) and the basics of microfluidic techniques will be a welcome advantage.
The call is open to all those who are not PhD holders and are not students at the doctoral schools.
Key assessment criteria
The Commission will take into account the following criteria:
a)competences of candidates to perform specific tasks in a research project, (70 % of the final score)
b)previous scientific achievements of candidates, including publications in the renowned publishers/scientific journals, (30 % of the final score)
The scholarship will be awarded in accordance with the NCN regulations: Annex to NCN Council Resolution No 95/2020 of 14 September 2020 amending the Regulations on awarding funding for research tasks funded by the National Science Centre as regards research projects https://ncn.gov.pl/sites/default/files/pliki/uchwaly-rady/2020/uchwala95_2020-zal1_ang.pdf
and in accordance with the Employment policy of the Institute of Physical Chemistry PAS https://ichf.edu.pl/files/csr/ipc-procedures.pdf
How to Apply: Send application directly to email@example.com;
IMPORTANT! email subject: “Recruitment no. 22/2021”
Additionally, the applicant is required to submit simultaneously their application to the online recruitment system of Warszawska Szkoła Doktorska Nauk Ścisłych i
BioMedycznych [Warsaw Doctoral School “Warsaw-4-PhD” http://warsaw4phd.pl] between 04th August and 18th of August 2021 (follow updates within the Candidates → Admission section).
More details about the recruitment for „Warszawska Szkoła Doktorska Nauk Ścisłych i BioMedycznych”:
Linked topic of the thesis:
Project no. 3.1 Wysokoprzepustowy układ mikrofluidyczny do szybkiego wyznaczania stałej równowagi tworzenia kompleksów między biomolekułami: zastosowanie do oddziaływania RNA z DNA (prof. dr hab. Robert Hołyst)
The best applicants will be invited for an interview (on-site or online). The interview for „Warszawska Szkoła Doktorska Nauk Ścisłych i BioMedycznych” (Warsaw
Doctoral School “Warsaw-4-PhD”) will be carried out between 06.09 – 16.09 2021 at the IPC-PAS.
The commission evaluates applications on a point scale.
At the starting date of the work within the project, applicant should be enrolled to a doctoral school.
The scholarship will be awarded to the person who obtains the highest number of points.
If the top candidate does not sign the contract, due to the resignation, we reserve the right to choose the next candidate from the ranking list.
The results of the competition are made public.
Archival announcement. We would like to thank all candidates for their submitted applications.