International Centre for Translational Eye Research

Research group no. 3

International Centre for Translational Eye Research

Group leader

prof. dr hab. Maciej Wojtkowski

Research topics

The main research expertise of the group focuses on the fundamental physical aspects of optical imaging, the development of novel optical imaging methods and demonstration of their applications to biology and medicine. The core competence of POB is in the comprehensive development of new optical methods combining low coherence interferometry, advanced spectroscopy and fluorescence. This expertise includes ability of fundamental – physical description of methods; designing, construction, and optimization of ergonomic set-ups; development of novel data processing and data acquisition software tools. 

Members

  • dr Dawid Borycki 
  • dr Andrzej Foik
  • dr Karol Karnowski 
  • dr Katarzyna Kordecka
  • mgr Jadwiga Milkiewicz 
  • dr Jagoda Płaczkiewicz
  • dr Marcin Tabaka
  • dr inż. Stefania Robakiewicz
  • dr Vineeta Kaushik
  • dr inż. Marta Mikuła-Zdańkowska
  • dr inż. Kamil Liżewski
  • dr Natalia Ochocka-Lewicka
  • mgr Piotr Rutkowski
  • dr hab. Dawid Borycki
  • dr Michał Dąbrowski
  • mgr inż. Bartłomiej Bałamut
  • dr Karol Karnowski
  • dr Mehdi Borjkhani
  • mgr inż. Milena Mućka
  • mgr inż. Lucyna Piórkowska
  • mgr inż. Anna Galińska
  • dr Anna Posłuszny

Publications

2021

Liebert, A., Torricelli, A., Pifferi, A., Contini, D., Borycki, D., Colombo, L., Pagliazzi, M., Sawosz, P., Samaei, S., Wojtkiewicz, S., Durduran, T., Torricelli, A., Torricelli, A., Pifferi, A., Pifferi, A., & Liebert, A.
Performance assessment of laser sources for time-domain diffuse correlation spectroscopy.
Biomedical Optics Express, https://doi.org/10.1364/BOE.432363

Liu, W., Qian, R., Xu, S., Chandra Konda, P., Jönsson, J., Harfouche, M., Borycki, D., Cooke, C., Berrocal, E., Dai, Q., Wang, H., & Horstmeyer, R.
Fast and sensitive diffuse correlation spectroscopy with highly parallelized single photon detection.
APL Photonics, https://doi.org/10.1063/5.0031225

Auksorius, E., Borycki, D., & Wojtkowski, M.
Multimode fiber enables control of spatial coherence in Fourier-domain full-field optical coherence tomography for in vivo corneal imaging.
Optics Letters, https://doi.org/10.1364/OL.417178

Untracht, G. R., Karnowski, K., & Sampson, D. D.
Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging.
APL Photonics, https://doi.org/10.1063/5.0052258

Consejo, A., Jiménez-García, M., Issarti, I., & Rozema, J. J.

Detection of Subclinical Keratoconus With a Validated Alternative Method to Corneal Densitometry.

Translational Vision Science & Technology, https://doi.org/10.1167/TVST.10.9.32

Tack, M., Kreps, E. O., Zaeytijd, J. De, & Consejo, A.

Scheimpflug-Based Analysis of the Reflectivity of the Cornea in Marfan Syndrome.

Translational Vision Science & Technology, https://doi.org/10.1167/TVST.10.9.34

Liebert, A., Torricelli, A., Pifferi, A., Contini, D., Borycki, D., Colombo, L., Pagliazzi, M., Sawosz, P., Samaei, S., Wojtkiewicz, S., Durduran, T., Torricelli, A., Torricelli, A., Pifferi, A., Pifferi, A., & Liebert,

A. Performance assessment of laser sources for time-domain diffuse correlation spectroscopy.

Biomedical Optics Express, https://doi.org/10.1364/BOE.432363

Frankowski, J. C., Foik, A. T., Tierno, A., Machhor, J. R., Lyon, D. C., & Hunt, R. F.
Traumatic brain injury to primary visual cortex produces long-lasting circuit dysfunction.
Communications Biology, https://doi.org/10.1038/s42003-021-02808-5

Boguslawski, J., Palczewska, G., Tomczewski, S., Milkiewicz, J., Kasprzycki, P., Stachowiak, D., Komar, K., Marzejon, M. J., Sikorski, B. L., Hudzikowski, A., Głuszek, A., Łaszczych, Z., Karnowski, K., Soboń, G., Palczewski, K., & Wojtkowski, M.
In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope.
The Journal of Clinical Investigation, https://doi.org/10.1172/JCI154218

2022

Auksorius, E., Borycki, D., Wegrzyn, P., Žičkienė, I., Adomavičius, K., Sikorski, B. L., & Wojtkowski, M.
Multimode fiber as a tool to reduce cross talk in Fourier-domain full-field optical coherence tomography.
Optics Letters, https://doi.org/10.1364/OL.449498

Stachowiak, D., Marzejon, M., Bogusławski, J., Łaszczych, Z., Komar, K., Wojtkowski, M., & Soboń, G.
Femtosecond Er-doped fiber laser source tunable from 872 to 1075 nm for two-photon vision studies in humans.
Biomedical Optics Express, https://doi.org/10.1364/BOE.452609

Curatolo, A., Borycki, D., Auksorius, E., Wojtkowski, M., Wegrzyn, P., & Tomczewski, S.
Light-adapted flicker optoretinograms captured with a Spatio-Temporal Optical Coherence-Tomography (STOC-T) system.
Biomedical Optics Express, https://doi.org/10.1364/BOE.444567

Choi, E. H., Suh, S., Foik, A. T., Leinonen, H., Newby, G. A., Gao, X. D., Banskota, S., Hoang, T., Du, S. W., Dong, Z., Raguram, A., Kohli, S., Blackshaw, S., Lyon, D. C., Liu, D. R., Palczewski, K., & Suh, S.
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration.
Nature Communications, https://doi.org/10.1038/s41467-022-29490-3

2023

Palczewska, Grazyna; Wojtkowski, Maciej; Palczewski, Krzysztof

From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation

PROGRESS IN RETINAL AND EYE RESEARCH 2023 93, , -101170

.

De Jonghe, Joachim; Kaminski, Tomasz S.; Morse, David B.; Tabaka, Marcin; Ellermann, Anna L.; Kohler, Timo N.; Amadei, Gianluca; Handford, Charlotte E.; Findlay, Gregory M.; Zernicka-Goetz, Magdalena; Teichmann, Sarah A.; Hollfelder, Florian

spinDrop: a droplet microfluidic platform to maximise single-cell sequencing information content

NATURE COMMUNICATIONS 2023 14, 1, -

.

Luu, Jennings C.; Saadane, Aicha; Leinonen, Henri; Choi, Elliot H.; Gao, Fangyuan; Lewandowski, Dominik; Halabi, Maximilian; Sander, Christopher L.; Wu, Arum; Wang, Jacob M.; Singh, Rupesh; Gao, Songqi; Lessieur, Emma M.; Dong, Zhiqian; Palczewska, Grazyna; Mullins, Robert F.; Peachey, Neal S.; Kiser, Philip D.; Tabaka, Marcin; Kern, Timothy S.; Palczewski, Krzysztof

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023  120, 19, -e2221045120

.

Zachary J. Engfer, Dominik Lewandowski, Zhiqian Dong, Grazyna Palczewska, Jianye Zhang, Katarzyna Kordecka, Jagoda Placz-kiewicz, Damian Panas, Andrzej T. Foik, Marcin Tabaka, Krzysztof Palczewski,

Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023 120, 19, -e2221045120

.

Marcotulli, Martina; Tirelli, Maria Celeste; Volpi, Marina; Jaroszewicz, Jakub; Scognamiglio, Chiara; Kasprzycki, Piotr; Karnowski, Karol; Swieszkowski, Wojciech; Ruocco, Giancarlo; Costantini, Marco; Cidonio, Gianluca; Barbetta, Andrea

Microfluidic 3D Printing of Emulsion Ink for Engineering Porous Functionally Graded Materials

ADVANCED MATERIALS TECHNOLOGIES 2023 8, 5, -

.

Kaushik, Vineeta; Gessa, Luca; Kumar, Nelam; Fernandes, Humberto

Towards a New Biomarker for Diabetic Retinopathy: Exploring RBP3 Structure and Retinoids Binding for Functional Imaging of Eyes In Vivo

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  2023  24, 5, -4408

.

Vineeta Kaushik, Michał Dabrowski, Luca Gessa, Nelam Kumar, Humberto Fernandes   

Two-photon excitation fluorescence in ophthalmology: safety and improved imaging for functional diagnostics

FRONTIERS IN MEDICINE 2023 10, 1293640

.

Marzejon, Marcin J.; Kornaszewski, Lukasz; Wojtkowski, Maciej; Komar, Katarzyna

Laser pulse train parameters determine the brightness of a two-photon stimulus

BIOMEDICAL OPTICS EXPRESS  2023  14, 6, 2857-2872

.

María Pilar Urizar, Enrique Gambra, Alberto de Castro, Álvaro de la Peña, Daniel Pascual, Onur Cetinkaya, Susana Marcos, and Andrea Curatolo

Long-range frequency-domain optical delay line based on a spinning tilted mirror for low-cost ocular biometry

BIOMEDICAL OPTICS EXPRESS  2023  14, 6521-6541

.

María Pilar Urizar, Enrique Gambra, Alberto de Castro, Álvaro de la Peña, Onur Cetinkaya, Susana Marcos, and Andrea Curatolo

Optical beam scanner with reconfigurable non-mechanical control of beam position, angle, and focus for low-cost whole-eye OCT imaging

BIOMEDICAL OPTICS EXPRESS 2023  14, 4468-4484

.

E. Martínez-Enríquez, A. Curatolo, A. de Castro, J. S. Birkenfeld, A. M. González, A. Mohamed, M. Ruggeri, F. Manns, Z. Fer-nando, and S. Marcos

Estimation of the full shape of the crys-talline lens in-vivo from OCT images using eigenlenses

BIOMEDICAL OPTICS EXPRESS 2023  14, 608-626

.

Boguslawski, Jakub; Tomczewski, Slawomir; Dabrowski, Michal; Komar, Katarzyna; Milkiewicz, Jadwiga; Palczewska, Grazyna; Palczewski, Krzysztof; Wojtkowski, Maciej

In vivo imaging of the human retina using a two-photon excited fluorescence ophthalmoscope

STAR PROTOCOLS 2023 4, 2, -102225

2024

Leinonen Henri; Zhang Jianye; Occelli Laurence M.; Seemab Umair; Choi Elliot H.; Marinho Luis Felipe L. P.; Querubin Janice; Kolesnikov Alexander V.; Galińska Anna; Kordecka Katarzyna; Hoang Thanh; Lewandowski Dominik; Lee Timothy T.; Einstein Elliott E.; Einstein David E.; Dong Zhiqian; Kiser Philip D.; Blackshaw Seth; Kefalov Vladimir J.; Tabaka Marcin; Foik Andrzej; Petersen-Jones Simon M.; Palczewski Krzysztof , A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models , NATURE COMMUNICATIONS , 2024, 15, 1, 5943

Makowski Adrian; Dąbrowski Michał; Antolovic Ivan Michel; Bruschini Claudio; Defienne Hugo; Charbon Edoardo; Lapkiewicz Radek; Gigan Sylvain , Large reconfigurable quantum circuits with SPAD arrays and multimode fibers , OPTICA , 2024, 11, 3, 340- 343

Borycki Dawid; Auksorius Egidijus; Węgrzyn Piotr; Liżewski Kamil; Tomczewski Sławomir; Zickiene Ieva; Adomavicius Karolis; Karnowski Karol; Wojtkowski Maciej , Multiwavelength laser doppler holography (MLDH) in spatiotemporal optical coherence tomography (STOC-T) , BIOCYBERNETICS AND BIOMEDICAL ENGINEERING , 2024, 44, 1, 264- 275

Liżewski Kamil; Tomczewski Sławomir; Borycki Dawid; Węgrzyn Piotr; Wojtkowski Maciej , Imaging the retinal and choroidal vasculature using Spatio-Temporal Optical Coherence Tomography (STOC-T) , BIOCYBERNETICS AND BIOMEDICAL ENGINEERING , 2024, 44, 1, 95- 104

Węgrzyn Piotr; Kulesza Wiktor; Wielgo Maciej; Tomczewski Sławomir; Galińska Anna; Balamut Bartłomiej; Kordecka Katarzyna; Cetinkaya Onur; Foik Andrzej; Zawadzki Robert J.; Borycki Dawid; Wojtkowski Maciej; Curatolo Andrea , In vivo volumetric analysis of retinal vascular hemodynamics in mice with spatio-temporal optical coherence tomography , NEUROPHOTONICS , 2024, 11, 4

Przemysław Struk Sławomir Bargiel Michał Józwik Bartosz Mirecki Maciej Wojtkowski Huikai Xie and Christophe Gorecki , Optical coherence tomogra-phy imaging by a fully inte-grated MOEMS endomicros-copy probe with Mirau micro-interferometer and two axis electrothermal micro-scanner using Lissajous trajectory scanning , IEEE SENSORS JOURNAL , 2024, 24, 9, 13903-13913

Du Samuel W.; Komirisetty Ravikiran; Lewandowski Dominik; Choi Elliot H.; Panas Damian; Suh Susie; Tabaka Marcin; Radu Roxana A.; Palczewski Krzysztof , Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration , JOURNAL OF BIOLOGICAL CHEMISTRY , 2024, 300, 6, 107344

Lewandowski Dominik; Gao Fangyuan; Imanishi Sanae; Tworak Aleksander; Bassetto Marco; Dong Zhiqian; Pinto Antonio F. M.; Tabaka Marcin; Kiser Philip D.; Imanishi Yoshikazu; Skowrońska-Krawczyk Dorota; Palczewski Krzysztof , Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice , JOURNAL OF BIOLOGICAL CHEMISTRY , 2024, 300, 5, 107291

Hackmann Michael J.; Cairncross Alvenia; Elliot John G.; Mulrennan Siobhain; Nilsen Kris; Thompson Bruce R.; Li Qingyun; Karnowski Karol; Sampson David D.; Mclaughlin Robert A.; Cense Barry; James Alan L.; Noble Peter B. , Quantification of smooth muscle in human airways by polarization-sensitive optical coherence tomography requires correction for perichondrium , AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY , 2024, 326, 3, L393- L408

Tomczewski Sławomir; Węgrzyn Piotr; Wojtkowski Maciej; Curatolo Andrea , Chirped flicker optoretinography for in vivo characterization of human photoreceptors frequency response to light ' , OPTICS LETTERS , 2024, 49, 9, 2461- 2464

Kaushik Vineeta; Dąbrowski Michał; Gessa Luca; Kumar Nelam; Fernandes Humberto , Two-photon excitation fluorescence in ophthalmology: safety and improved imaging for functional diagnostics , FRONTIERS IN MEDICINE , 2024, 10, 1293640

Mogharari Neda; Wojtkiewicz Stanisław; Borycki Dawid; Liebert Adam; Kacprzak Michał , Time-domain diffuse correlation spectroscopy at large source detector separation for cerebral blood flow recovery , BIOMEDICAL OPTICS EXPRESS , 2024, 15, 7, 4330- 4344

Kaczkoś Oliwia; Zielińska Agnieszka; Pniewski Jacek; Wojtkowski Maciej; Komar Katarzyna , Method for the determination of the luminance of two-photon vision stimuli , BIOMEDICAL OPTICS EXPRESS , 2024, 15, 10, 5818- 5830

Komar Katarzyna , Two-photon vision - Seeing colors in infrared , VISION RESEARCH , 2024, 220, 108404

Raciborska Ida; Dzwiniel Piotr; Kordecka Katarzyna; Posluszny Anna; Waleszczyk Wioletta J.; Wróbel Andrzej , Optical imaging of the intrinsic signal as a tool to characterize orientation sensitivity in the primary visual cortex of the young mouse , ACTA NEUROBIOLOGIAE EXPERIMENTALIS , 2024, 84, 1, 1- 25