Dioscuri Centre for Physics and Chemistry of Bacteria Institute of Physical Chemistry PAS Warsaw, Poland
National Science Centre (NCN)
Project title, type and project number
Phenotypic heterogeneity in cancer chemotherapy, POLS, UMO-2020/37/K/NZ2/03737, 20/2021
Dr Bartłomiej Wacław
We seek an excellent candidate with experience in cancer biology, tissue culture, or optical imaging to work on experimental in vitro models of cancer chemotherapy. The candidate will investigate differences in single-cell response of normal and cancer cells to chemotherapy, and how the response correlates with phenotypic, non-genetic heterogeneity prior to treatment. The project will help to better understand why chemotherapy fails, quantify the contribution of different mechanisms leading to resistance, and motivate better, predictive mathematical models of cancer treatment.
This post is funded through the POLS grant “Phenotypic heterogeneity in cancer chemotherapy” carried out in collaboration with Professor Hesso Farhan, the Institute of Basic Medical Sciences at the University of Oslo, and the Institute of Pathophysiology, Medical University of Innsbruck in Austria.
Number of vacancies
Key responsibilities include
1. Undertaking research projects in pursuit of goals agreed with the supervisor. This will involve deciding (with the supervisor) on the detailed direction of the research, formulating a strategy for day-to-day research work, implementing the strategy (without close supervision) and reporting progress to the supervisor and other research team members.
2. Communicating research strategies and results to team members and collaborators through talks and discussions, as well as learning about others’ research through seminars and journal clubs.
3. Assisting with supervision of junior researchers (Master and PhD students), where appropriate.
4. Writing reports and scientific papers.
5. Attending and presenting at workshops and conferences.
The candidate is also expected to work closely with experimentalists from Prof. Hesso Farhan’s group in Innsbruck, Austria.
Position in the project
A postdoctoral researcher in optical imaging of in vitro models of cancer chemotherapy
Gross salary about 8300 PLN/month (net salary approx. 6600 PLN, approx. 1500 EUR). In exceptional cases, the salary may be open to negotiations.
Position starts on
Maximum planned period of contract/stipend agreement
The successful candidate will benefit from working in an international, interdisciplinary research group, a newly refurbished cell culture lab equipped with automated epifluorescent microscopes, and separate office space. The candidate will work closely with other experimentalists and modellers from the Dioscuri Centre and collaborating groups, in particular with Prof. Farhan’s group. The candidate will have the opportunity to regularly visit Prof. Farhan’s group in Innsbruck.
Biology Biomedicine Biological physics
Scientific profile of a candidate
Recognised Researcher (R2)
Key assessment criteria
All documents (including the reference letters) should be emailed to email@example.com quoting “Rekrutacja nr 20/2021” in the subject line.
About the Dioscuri Centre
The Centre’s main objective is to better understand the growth and evolution of pathogenic cells in human diseases from the chemistry and physics viewpoint. While most of the group works on bacterial infections, the Centre is also developing a research programme in cancer biology. In particular, we would like to improve the knowledge of mechanisms that lead to resistance to cancer chemotherapy. The members of the Centre use experimental in vitro models, computer simulations and mathematical theory to create data driven, quantitative models of bacterial infections and cancer. We anticipate that these models can help to develop new treatment modalities. To facilitate translation from the bench to the bedside, the Centre collaborates with biomedical researchers and with industrial partners.
The Centre is co-funded by the Polish Ministry of Science and Higher Education and the German Federal Ministry of Education and Research, with additional support coming from NAWA and POLS.
Deadline for the settlement of the competition
Archival announcement. We would like to thank all candidates for their submitted applications.