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We seek a highly motivated and enthusiastic Postdoctoral Researcher at the Institute of Physical Chemistry, Polish Academy of Sciences. The position is part of the project entitled “Comprehensive, multimodal profiling of chromatin states and gene expression in single cells”, financed by the NCN (National Science Centre). Our laboratory at IPC PAS/ICTER provides an international and interdisciplinary research environment with close links to genomics, single-cell sequencing, molecular biology, biotechnology, and bioinformatics. The project involves multimodal (transcriptomic and epigenomic) profiling of immune systems using in-house high-throughput single-cell sequencing methods.

Details about the project:

The single-cell sequencing approaches allow researchers to uncover rare cell types, reveal the diversity of cell populations, infer the cellular trajectories, and discover their regulatory mechanisms. Recent progress in developing multimodal single-cell techniques has enabled us to study complex biological systems and processes simultaneously at multiple layers of gene regulation. Understanding how the gene expression programs are modulated over time in response of cells to stimuli or during disease progression is one of the long-standing challenges. We aim to develop new multimodal approaches to comprehensively interrogate the dynamics of gene regulatory elements, and downstream gene expression programs, using state-of-the-art chemical, biophysical, and genomic tools.

About the group: The Computational Genomics Group at IPC PAS led by dr. Marcin Tabaka leverages experimental and computational approaches in high-throughput single-cell transcriptome and epigenome profiling to address fundamental questions in biomedical research (https://tabaka-lab.org).

• Designing, executing, analyzing, and interpreting experiments including high throughput single-cell multimodal profiling
• Assessing quality controls of Next Generation Sequencing data generated in the project
• Optimization of protocols for multimodal analyses (RNA-seq, ATAC-seq, chromatin proteins, and histone modifications profiling) of single cells
• Prepare and write scientific papers for leading journals

• full-time work contract, not exceeding 2028-05-03
• Engagement into an ambitious research program and opportunity to build an academic career.

The job in the exciting interdisciplinary project. The successful candidate will be able to take advantage of all programs in the IPC PAS, including Young Scientists of IPC PAS competition and Mobility of Young Scientists of IPC PAS competition. The Institute provides an opportunity to participate in ERASMUS+ program.

• Ph.D. degree in Biotechnology, Biology, Genomics, Medicine or related quantitative discipline obtained not earlier than 7 years before the engagement in the project (this period might be longer due to family reasons according to NCN rules).
• Solid knowledge and familiarity with techniques in Genomics
• Familiarity with Next Generation Sequencing
• Familiarity with single-cell methods in Genomics
• Very good command of spoken and written English is required

The Commission will take into account the following criteria and evaluate applications on a point scale:

• Competence for specific tasks in a research project
• Previous scientific achievements (publication record)
• References
• Candidate’s own initiative in research projects.