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The primary objective of the project is to develop the first Stimulated Raman Scattering (SRS) microscopic-microfluidic system for non-invasive imaging of live cells and apply it to rapid leukemia cell imaging, diagnostics, sorting and assessment of chemosensitivity in vitro. Multidisciplinary teams of experts establishing the consortium will characterize Raman spectra of leukemic cells and link them to biological features of the disease. These data will be thereafter used to design and construct, microfluidic-based diagnostic device utilizing SRS microscopy which will allow for quick and reliable differentiation between different types of leukemia cells providing clinicians with quantitative information crucial to make proper decisions during the course of the treatment. The envisaged microfluidic-SRS instrument will fill the gap in the current diagnostic methodology of leukemia, accelerate diagnostics and decrease its cost. Moreover the developed methodology will open new areas of application in leukemia research.

We are looking for a highly motivated experienced technical staff with strong background in advanced mathematics (statistics or probability theory), statistical physics or similar; ideally also with experience in droplet-based microfluidics. The successful candidate will join a multinational and interdisciplinary team and will be responsible for analyzing experimental data (including microfluidic cell encapsulation and cell/ droplet sorting) and mathematical modeling of single cell heterogeneity, distribution of multi-species, cell-cell pairing and interaction and cancer drug resistance.

• Statistical calculations and mathematical modeling of single-cell encapsulation and optimization of flow parameters according to the proposed model Institute of Physical Chemistry Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw, Poland www.ichf.edu .pl
• Characterization of the phenotypic heterogeneity of leukemia and healthy cells in contact with anticancer drugs and antibiotics during co-cultivation with pathogens.
• Cooperation with researchers, including communication with English-speaking colleagues

• Monthly salary of 5 000 PLN (brutto-brutto) based on a part-time work contract. The position is financed by the Foundation for Polish Science Team-NET project No. POIR.04.04.00-00-16ED/18. The position requires 50% time involvement and is scheduled to last 12 months.
• Engagement in an ambitious research program.
• Work in the outstanding scientific institution, in a dynamic research group with members representing diverse interests and qualifications. see website: https://ichf.edu.pl/en/groups/microfluidics-and-complex-fluids-research-group http://ichf.pong.pl/en/

• Solid knowledge in descriptive and inferential statistics, probability theory and data analysis, especially in analysis of microfluidic-based digital (live-dead) droplet assays
• Analytical thinking and critical problem solving skills
• Fluent in spoken and written English
• Flexibility and ability to work in a multidisciplinary and multicultural research team