Microfluidics and Complex Fluids Group Department of Soft Condensed Matter, IPC PAS
Fundation for Polish Science
Project title, type and project number
RApID -Label-free and rapid optical imaging, detection and sorting of leukemia cells; TEAM-NETProject No. POIR.04.04.00-00-16ED/18
Background: Leukemias are malignancies originating from hematopoietic or lymphoid precursors. They are caused by genetic lesions leading to biochemical, proteomic and metabolomics abnormalities. Current leukaemia diagnostics is based on genetic and phenotypic characterization of these changes. The RApID (Raman Imaging for Diagnostics) project aims to develop the first Stimulated Raman Scattering (SRS) microscopic-microfluidic system for non-invasive imaging of live cells and apply it to rapid leukaemia cell imaging, diagnostics and sorting. By integrating the multidisciplinary expertise from a broad range of fields, consortium partners will characterize Raman spectra of leukemic cells and link them to clinico-biological features of the disease. Our team at the Group of Microfluidics and Complex Fluids will use these data to design and fabricate an innovative microfluidic device utilizing SRS microscopy for label-free, rapid leukaemia cell detection, which will help in quick and reliable differentiation between different types of leukemia cells providing clinicians with quantitative information that can be applied to diagnostics. Such an automated device will decrease the cost and time of diagnosis of leukemias and will be helpful in making fast yet proper decisions during the course of the treatment.
The successful candidate will join a multinational and interdisciplinary team of scientists and will be responsible for i) designing, constructing and testing microfluidic cell sorters separating leukemia cellsfrom WBCs, ii) integration ofthe cell sorter with the Stimulated Raman Spectrometer (SRS) and iii) optimization and automation ofthe systemfor increased sensitivity, selectivity and throughput. Additionally the candidate will provide support forPhD students participating in the project.
Key responsibilities include
Position in the project
Senior postdoc position
12 000 PLN (total employment cost), i.e. ca. 7000 PLN net.
Position starts on
Maximum planned period of contract/stipend agreement
Link to Euraxess websitesee website
microfluidics, micro engineering, physics/optics or similar, ideally also with experience in cell manipulation, biotechnology or development of medical diagnostic tools
Scientific profile of a candidate
Established Researcher (R3)
Archival announcement. We would like to thank all candidates for their submitted applications.