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The primary objective of the project is to develop the first Stimulated Raman Spectroscopy (SRS) microfluidic system for non-invasive imaging of live leukemic cells (RApID) and apply it to rapid diagnostics and assessment of chemosensitivity in vitro.

The newly developed diagnostic instrument will fill the gap in the current diagnostic methodology of leukemia. The proposed approach will objectify and accelerate initial diagnostics and follow up of leukemia patients; in addition, such approach would be potentially automatable, opening new areas of application in leukemia research. Given the fact that initial/follow-up leukemia diagnostic work-up requires experienced, multidisciplinary approach and consumes considerable costs (>3100 USD for initial diagnostic procedures in USA), the label-free imaging of leukemic cells might significantly accelerate this process and reduce its cost.

The research and development envisioned in this application will be conducted by the team of experts in the fields related to the Project. Partners of Consortium consist of five scientific institutions None of the essential parts of the RApID instrument (SRS microscope, microfluidic trap & release system) are commercially available, so they must be developed by the Partners within the Project.

The employed Master student will be participating in constructing and testing RApID device, and in carrying out experiments planned in the project with use of the RApID device in Laser Center at IPC PAS (IPC PAS LC).

1. Participating in development of novel fiber lasers and methods of light conversion for stimulated Raman microscopy.
2. Participating in measurements of biological materials with use of SRS microscopy.
3. Data analysis.

1. Work in the outstanding scientific institution in the dynamic research group of the Laser Center of IPC PAS
2. Scientific and organizational support.
3. Access to the modern research equipment.
4. Possibility to collaborate with multidisciplinary research group (Warsaw University, Medical University of Lodz, Institute of Hematology and Transfusion, Jagiellonian University).

1. Status of Master Student (in optics/photonics/physics or related disciplines)
2. Ability to independently and creatively solve technical problems
3. Good work organization
4. Responsibility and diligence
5. Knowledge of English language at least at intermediate level (B2)
6. Willing to acquire new skills and competences

Candidates will be evaluated basing on their knowledge and scientific achievements in the area of the project, realized grants and stages, motivations, level of English and communications and interpersonal skills.