|Laboratory of Chromatograph Analysis|
|Dr. Monika Asztemborska|
Phone: +48 (22) 343-3296
Build. 7, room 244b
Expert Laboratory of Chiral Chromatography performs chromatographic studies of mixtures
which are otherwise separable with difficulty, e.g.
The area of research includes physicochemical studies on complexation processes themselves (stability, stoichiometry, thermodynamic functions).
- enantiomeric composition of terpenic hydrocarbons in essential oils (it has been found that quality and quantity of terpens produced by plants depends not only on genetic factors but also on micro and macro environment)
- enantiomeric composition of some therapeutics applied in the treatment of liver and kidney diseases (they differ from one another by enantiomeric composition)
- micro preparative methods for ultra pure standards of optically active hydrocarbons (e.g. (-) camphene samples of 94% enantiomeric purity)
- methods to control enantiomeric purity of chiral drugs (e.g. bromofosfamide and its metabolites).
The validation of the chromatographic methods is also performed.
Our equipment includes:
Two Hewlett-Packard Model 5890 gas chromatographs with FID detectors. Chiral capillary columns
modified by various derivatives of cyclodextrins. Classical columns covered with solutions of cyclo-dextrins.
Waters and Knauer chromatographs equipped with RI, Chiralyser and UV-VIS detectors.
As the chiral selectors we use native cyclodextrins, cholic acids and its derivatives as the additives to the
We also have chiral columns: e.g. Cyclobond I 2000, Chiracel OD and Chiralpak AD, IA and IB.
Thermo Separation CE Ultra and P/ACE MDQ Beckman Coulter apparatus.
Dr. Monika Asztemborska, e-mail: firstname.lastname@example.org
The details can be obtained:
Department II. Institute of Physical Chemistry PAS
Kasprzaka 44/52, 01-224 Warszawa