IPC PAS INVENTIONS OFFER
PAGE NOT UPDATED SINCE DECEMBER 2015

CURRRENT INSTITUTE'S PATENTS

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IPC PAS PATENT APPLICATIONS, PATENTS OFFERED FOR SALE, LICENCE, COOPERATION

INVENTIONS FOR COOPERATION AND FURTHER DEVELOPMENTS


Patent applications, patent offered for sale, licence, cooperation:

Inventions for cooperation and further development:



OFFER no. 5/15

Title of the invention:
Film of conductive polymer poly(3,3'-bithiophene), method of its preparation and its application for selective determination of creatinine and/or ascorbic acid

Inventors:
Piotr Bocian, Marta Sosnowska, Paweł Borowicz, Krzysztof Noworyta

Field:
Analytical chemistry
Chemistry new materials
Field II:
Instruments: Analysis of biological materials
Chemistry: Macromolecular chemistry, polymers, Surface technology, coating

Summary:
Invention describes method of fabrication of the polimer recognition layer containing 3,3'-bithiophene on the conducting electrodes by the use of electrochemical polymerization. Fabrication is performed from the solution containing 3,3'-bithiophene functional in mixture of polar organic solvents at controlled temperature in the range from 22 to 34oC. Moreover, the invention encompasses application of the fabricated recognition films as recognition element of the impedimetric chemosensor for selective determination of creatinine and/or ascorbic acid, especially in body fluids.

Advantages / innovative aspects:

  • Facile fabrication.
  • Durability and chemical stability of the recognition layer.
  • High selectivity and detectability of the chemosensor.
  • Possible determination of two analytes simultaneously.

Keywords:
Creatinine, ascorbic acid, conducting polymers, chemosensors, biomarkers, renal diseases

Use:
Polymers, Analytical Chemistry, Medical Diagnostics, Methods and analytical equipment

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-412551 – 02.06.2015 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 4/15

Title of the invention:
Method for deposition of analyte from solution onto the substrate for surface enhanced spectroscopy in the electric field

Inventors:
Łukasz Richter, Jan Paczesny, Monika Księżopolska-Gocalska, Robert Hołyst

Field:
Analytical chemistry
Field II version:
Instruments: Measurement, Analysis of biological materials
Chemistry: Organic fine chemistry, Pharmaceuticals, Basic materials chemistry, Surface technology, coating, Chemical engineering

Summary:
The invention is a method of deposition of analyte from the solution onto the substrate for SES (surface enhanced spectroscopy), including process of deposition in electric field. The method consists of: putting substrate in the system; applying the solution of analyte; deposition of analyte in electric field for certain time. Presented method improve homogeneity of the results and sensitivity of measurement.

Advantages / innovative aspects:

  • fast and convenient method for deposition of the analyte from solution
  • increase in homogeneity and sensitivity of measurements

Keywords:
surface enhanced spectroscopy deposition of the analyte, electric field

Use:
Analytical chemistry, Diagnostics, Pharmacy and medicines, Environmental and sports medicine, Methods and analytical apparatus, Electric techniques

State of the progress:
prototype stage

Intellectual property rights:
Patent application no. P-412548 – 02.06.2015, Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachement:
Figure1. Results of SERS analysis of 4-mercaptobenzoic acid (PMBA) deposited on SERS substrates with different methods. Concentration of PMBA was 10-6 mol/l. Power of laser was 9 mW. Inset allows comparison of intensities of collected spectra

OFFER no. 3/15

Title of the invention:
Method of synchronization of pulsed lasers

Inventors:
Paweł Wnuk, Yuriy Stepanenko, Michał Nejbauer, Czesław Radzewicz, Piotr Skibiński, Jan Szczepanek

Field:
Instruments: Optics, Measurement, Control

Summary:
The invention describes the method of synchronization of pulsed laser with the substatential difference in the repetiion rate.

Advantages / innovative aspects:

  • The method allows to synchronize two lasers sources with relative jitter on the level of 25 ps,
  • The method describes purely electronic synchronization, which is much more cheper than the optical synchronization.

Keywords:
laser, electronic sychronization

Use:
All laser amplifier systems, especially optical parametric amplifiers with electronic synchronization, Automation, Laser technology

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent application no. P-412255 – 08.05.2015 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 2/15

Title of the invention:
Method of protein immobilization, especially myoglobin, on the surface of conducting or semiconducting electrode, method of preparation of polymer molecularly imprinted with the immobilized protein, the polymer film recognizing the protein and its application for the protein detection and determination

Inventors:
Marta Sosnowska, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Biosensors
Diagnostics

Summary:
The invention consists of the procedure of preparation of a polymer film molecularly imprinted with protein preparation and the method of its application for preparation of a chemosensor capable of selective determination of this protein. First, an inner polymer film with immobilized protein is deposited. Next, an outer polymer film of the bis(2,2'-bithien-5-yl)methylbenzoic acid monomer is electrochemically deposited around the protein forming a layer of the polymer molecularly imprinted with the protein. After subsequent protein extraction, so prepared polymer film is used as a recognition unit of a chemosensor. As an example of invention application, a chemosensor capable of myoglobin determination was prepared. Electrochemical impedance spectroscopy was used as the transduction technique in this chemosensor.

Advantages / innovative aspects:

  • Proposed methods allows for imprinting of protein of native conformation into the polymer that can be synthesized only in an organic solvent.
  • Using conducting polymers for preparation of chemosensors recognition unit allows for detection based on different transduction techniques.

Keywords:
molecularly imprinted polymer, myoglobin, chemosensor, chemical sensor, conducting polymer, electropolymerization, neutravidin, avidin, biotin

Use:
Plastics, Polymers, Analytical chemistry, Clinical research, Diagnostics, Health Service, Measuring sensors, Chemical techniques

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-412080 – 23.04.2015 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 1/15

Title of the invention:
Novel method of solid catalytic nanocomposites fabrication containing noble metals on polymeric matrix

Inventors:
Tomasz Andryszewski, Michalina Iwan, Jakub Sęk, Marcin Fiałkowski, Robert Hołyst

Field:
Chemistry new materials
Chemistry: Materials, metallurgy, Micro-structural and nano-technology

Summary:
The patent application reveals the synthetic procedure of 5 nm and 30 nm, Au, Ag, Pd and Pt nanoparticle preparation and their functionalization with aminothiolalkil ligands. The obtained nanoobjects possess the ability of spontaneous chemisorption at the surfaces of polymers that contain anhydride, -OH, -COOH or -CHO functional groups. These include polysaccharides and poly(vinyl) alcohol. The degree of coverage of polymeric matrices can be easily regulated, since the chemisorption process is quantitative. The application also reveals the method of preparation of nanocomposites containing up to four different metallic nanoparticles, which can be utilized in catalysis. All described processes take place at room temperature and in aqueous environment.

Advantages / innovative aspects:

  • The functionalization process takes place in aqueous environment and at room temperature.
  • Pd, Pt, Au and Ag nanoparticles can be utilized in the process, as well as mixtures of the above mentioned nanoparticles of any composition.
  • Polymers such as polysaccharides or polymers containing functional such as –OH, -COOH, -CHO, anhydride acid groups can be modified using the described method.
  • The polymer matrices can be modified both within the bulk structure and at the surface of polymers.
  • The polymeric matrices do not require any processing prior to the modification process.
  • The degree of nanoparticle coverage of the polymer matrix can be easily controlled, due to the fact that the modification process is qualitative.
  • The metallic nanoparticles form robust chemical bonds with the polymeric matrices, such as amide, imine, imide etc. bonds.
  • The obtained materials may be utilized in catalysis.

Keywords:
metallic nanoparticles, surface functionalization, chemisorption, catalysis

Use:
Preparation of heterogenous catalysts that contain up to four different metals in the form of nanoobjects.
Inorganic chemistry, Inorganic substances.

State of the progress:
Research completed

Intellectual property rights:
Patent application no. P-411554 – 13.03.2015 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 30/14

Title of the invention:
Microfluidic system for automatic formation of lipid membranes and testing of membrane protein activity

Inventors:
Tomasz Kamiński, Magdalena Czekalska, Piotr Garstecki

Field:
Analytical chemistry

Summary:
The invention comprises the microfluidic system that enables the reconstitution of stable and reproducible synthetic lipid bilayers. The lipid bilayer is formed between the seqence of aqueous droplets submerged in oil, when the phospholipid molecules self-organize at their interface. One of the possible applications of this method is a high-throughput screening of putative agents interacting with membrane proteins. Droplet microfluidics is a technology that would exclude the manual handling of fluids and enable replicable, high-throughput measurements. Thanks to the microfluidic control over the droplets it was possible to exchange them in an automated way and perform a rapid screen of different concentrations of an membrane protein inhibitors

Advantages / innovative aspects:

  • Innovation comprises the microfluidic system that combines the technologies of passive (use of hydrodynamic traps) and active (use of external valves) handling of droplets on a microfluidic chip. This technological synergy ensures that operation on droplets are conducted according to predefined protocol.
  • The artificial lipid membrane has an exceptional stability that supports long-term measurements.
  • The measurements of the activity of membrane proteins are highly reproducible and conducted with so far unattainable efficiency.
  • There is no contact between analyzed sample and the electrodes that measure the ion current throug membrane proteins. Consequently the ris of cross-contamination is greatly reduced.
  • Microfluidic system has an advantage of minute consumption of reagents.

Keywords:
Droplet microfluidics, Droplet Interface Bilayers, membrane proteins, high-throughput screening

Use:
Analytical chemistry, Antibiotics, Pharmacy and Medicines, Biochemistry and Biophysicist, Enzymology and Engineering of protein, Tests In vitro

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-410696 - 31.12.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachments:
1. Schema of system
2. 4 drops
3. Measurement of electricity
4. Movie

OFFER no. 29/14

Title of the invention:
A new bisbithienyl conducting polymer, molecularly imprinted with proteins, particularly with human serum albumin, its preparation and applications

Inventors:
Maciej Cieplak, Katarzyna Szwabińska, Chandra Bikram KC, Paweł Borowicz, Krzysztof Noworyta, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Chemical technology
Environmental chemistry

Summary:
A new conducting bisbithiopene polymer molecularly imprinted with human serum albumin (HSA) was fabricated. It was deposited as a few tenth nanometer-tick film on a gold electrode surface by potentiodynamic electropolymerization. The functional monomers used, vis., 2,2'-bithiophen-5-carboxylic acid and p-bis(2,2'-bithien-5-yl)methyl alanine were covalently attached to HSA before the polymerization. The 5,5',5''-tris[(2,2-bithien-5-yl)methane] was used as the crosslinking monomer. This polymer film served as the recognition element in an electrochemical chemosensor for selective detection and/or determination of HSA in urine and blood.

Advantages / innovative aspects:

  • Electrochemical sensors used for determination of human serum albumin are attractive alternatives to conventional methods based on colorimetric or fluorescence HSA detrminations.
  • Molecularly imprinted polymers (MIPs) may serve as recognition components of the chemosensors, and they can provide analytical information comparable to that provided by immunosensors, remining free of their drawbacks. The MIP-based chemosensors are more durable, simpler in fabrication, and cheaper than the immunosensors.
  • Electrochemical sensors, including those based on molecularly imprinted polymers, are significantly more sensitive, selective and, moreover, they reveal higher detectability than conventional analytical methods of detection of human serum albumin.
  • The use of semi-covalent imprinting resulted in formation of very well-defined molecular cavities in the polymer ensuring high selectivity of the chemosensor.
  • Detectability of the MIP-HSA chemosensor is sufficient to determine HSA in urine and blood samples.
  • Advantageously, the chemosensor is insensitive to the low molecular-weight inteferences present in the urine and blood samples. Moreover, it is highly selective with respect to three representative proteins accompanying HSA.

Keywords:
chemosensor, moleculary imprinted polymer, semi-covalent imprinting, conducting polymer, electropolymerization, human serum albumin, albuminouria diagnosis, hipoalbuminemia diagnosis, medical diagnosis, medical analysis, analitical chemistry

Use:
Human serum albumin (HSA) is mainly responsible for transport of several human body inherent important substances and xenobiotics including hormones, fatty acids, and drugs. Moreover, it maintains oncotic pressure and prevents photodegradation of folic acid. A low level of HSA in plasma (hypoalbuminemia) indicates liver failure, cirrhosis, and chronic hepatitis. Moreover, the HSA concentration can serve as an indicator of a coronary heart disease and multiple myeloma. Its moderate concentration, i.e., 30 to 300 µg/mL, in urea is indicative of microalbuminuria and, at higher concentrations, of albuminuria, both caused by kidney damage, most often resulting from diabetes or hypertension. Therefore, HSA determination is so much important for clinical analysis. Colorimetry is the most commonly used method of HSA determination. It relies on Bromocresol Green binding. However, it suffers from serious disadvantages. Most importantly, the HSA concentration is often overestimated with this method because equilibrium of the HSA reaction with this dye is not reached and, therefore, the analytical signal is time dependent. Apparently, this signal is rising fast all the time during the HSA determination. Moreover, Bromocresol Green may also react with other proteins present. Furthermore, fluorescence spectroscopy, often used for determination of HSA, is generally inadequate with respect to selectivity and stability. This is because fluorescence of other proteins present in biological samples can easily interfere the HSA emission. Only quite recently, the first, based on the Pittsburgh Green II dye, fluorescence protocol of HSA determination was developed affording the time independent response to HSA. Moreover, a label-free impedimetric HSA immunosensor based on silicon nitride was fabricated. However, it revealed disadvantages typical of immunosensors. That is, its fabrication was rather complicated and expensive. Besides, stability of anti-HSA antibodies used was quite limited. Moreover, this immunosensor could operate as a disposable device only because its sensitivity dropped as much as by 40% when HSA was extracted from its recognizing film after the first use. The heiren devised chemosensor allows for fast and selective electrochemical HSA determination without the nesesity of labeling this protein. It is easy to fabricate and, moreover, it is a reusable device. Hence, this chemosensor may find its use in clinical analysis.
Moreover, the method of semi-covalent imprinting of HSA developed heiren may be easely extended to produce chemosensors for selective determination of other proteins.

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409982 - 03.11.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 28/14

Title of the invention:
New conducting bis(bithiophene) polymer molecularly imprinted with neopterin, the method of its preparation and application of this polymer as a recognition unit of a chemosensor for selective detection and determination of neopterin

Inventors:
Piyush S. Sharma, Agnieszka Wojnarowicz, Marta Sosnowska, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Biosensors
Diagnostics

Summary:
The invention involves a conducting molecularly imprinted polymer (MIP) composed of 2,2'-bithiophene-5-boronic acid and 2-(cytosin-1-yl)ethyl p-bis(2,2'-bithien-5-yl)methylbenzolate as the functional monomers, and 2,4,5,2',4',5'-hexa(thiophene-2-yl)-3,3'-bithiophene as the cross-linking monomer, and molecular cavities imprinted with neopterin molecules as well as the method of its preparation by electropolymerization under potentiodynamic conditions. Moreover, the invention includes the use of the molecularly imprinted polymer as a recognition unit of a chemosensor for detection and selective determination of neopterin, especially in biological samples including blood and urine. The chemosensor potentiometrically transduces a chemical signal of neopterin recognition to the useful analytical signal manifested by the change of an open circuit potential (OPC).

Advantages / innovative aspects:

  • A conducting molecularly imprinted polymer (MIP) for selective determination of neopterin, a cancer biomarker, was devised and prepared.
  • Combination of the potentiometric signal transduction with the recognition using the tailor designed MIP film resulted in devising an easy to prepare and robust in use chemosensor.
  • The procedure of neopterin determination developed with the use of the chemosensor is superior in comparison to those conventional engaging HPLC and radioimmunoassays because these assays are time consuming and expensive.
  • The devised chemosensor successfully discriminates neopterin from its structural analogues.
  • The chemosensor successfully determines neopterin in the human serum samples, thus confirming its suitability in medical/clinical analysis.

Keywords:
Cancer biomarker, serum neopterin, open circuit potential, molecularly imprinted polymer, MIP, chemosensor, chemical sensor, clinical diagnosis

Use:
- The MIP-neopterin chemical sensor devised and fabricated for selective and sensitive detection and determination of neopterin, a cancer biomarker, especially in body fluids, such as blood serum and urine, can be used for early diagnosis of different cancers including the colon, ovarian, endometrial, cervical, renal, and breast cancer.
- The method of neopterin determination developed with the use of the proposed chemosensor can be alternative to conventional methods, such as HPLC and radioimmunoassays. The reported HPLC procedures include a preliminary acid deproteinization step, which may lead to the decrease of the amount of neopterin in a sample. Unfortunately, these assays are time consuming and expensive. In contrast, the developed method is fast, easy to operate, and inexpensive.
- Clinical research, Diagnostics, Physiology, Oncology, Measuring sensors

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409981 - 03.11.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 27/14

Title of the invention:
A new conducting bis(bithiophene) polymer molecularly imprinted with 2,4,6-trinitrophenol, a method of its preparation and its application for selective detection and/or determination of nitroaromatic explosives with using fluorescence spectroscopy

Inventors:
Tan Phat Huynh, Agnieszka Wojnarowicz, Alina Majka, Piotr Woźnicki, Paweł Borowicz, Francis D’Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Chemical technology
Environmental chemistry

Summary:
A new conducting polymer molecularly imprinded (MIP) with 2,4,6-trinitrophenol was devised and fabricated for use as the recognition unit of a chemosensor for selective recognition, due to p-p stacking interactions, and determination of 2,4,6-trinitrophenol. For that, the bis(2,2'-bithienyl)-(4-aminophenyl)methane functional monomer and 3,3'-bis[2,2'-bis(2,2'-bithiophene-5-yl)]thianaphthene, which played the role of both the cross-linking monomer and fluorophore, were used. The 2,4,6-trinitrophenol recognition signals of the MIP film were transduced to analytical signals of the changes of fluorescence intensity of the MIP film using fluorescent spectroscopy.

Advantages / innovative aspects:

  • Functional monomer enable rapid and selective recognition of 2,4,6-trintrophenol in the presence of its structural analogues, as well as signal transdaction, due to fluoresce properties of the molecularly imprinted polymer.
  • Simle and fast method of preparing of recognition film, based on direct deposinion on the surface of the transducer of the chemosensor via electropolymerization.

Keywords:
2,4,6-trinitrophenol, nitroaromatic explosive, thiophene, electropolymerization, molecularly imprinted polymer, fluorescence chemosensor

Use:
The chemosensor is suitable for detrmination of 2,4,6-trinitrophenol in body fluids as well as determination of other nitroexplosive. Organic substances, Analytical chemistry, Inorganic chemistry, Diagnostics, Toxicology, Measuring sensors, Chemical techniques, Dangerous materials

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409656 – 30.09.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachments:
Graphs

OFFER no. 27/14

Title of the invention:
A new conducting bis(bithiophene) polymer molecularly imprinted with 2,4,6-trinitrophenol, a method of its preparation and its application for selective detection and/or determination of nitroaromatic explosives with using fluorescence spectroscopy

Inventors:
Tan Phat Huynh, Agnieszka Wojnarowicz, Alina Majka, Piotr Woźnicki, Paweł Borowicz, Francis D’Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Chemical technology
Environmental chemistry

Summary:
A new conducting polymer molecularly imprinded (MIP) with 2,4,6-trinitrophenol was devised and fabricated for use as the recognition unit of a chemosensor for selective recognition, due to p-p stacking interactions, and determination of 2,4,6-trinitrophenol. For that, the bis(2,2'-bithienyl)-(4-aminophenyl)methane functional monomer and 3,3'-bis[2,2'-bis(2,2'-bithiophene-5-yl)]thianaphthene, which played the role of both the cross-linking monomer and fluorophore, were used. The 2,4,6-trinitrophenol recognition signals of the MIP film were transduced to analytical signals of the changes of fluorescence intensity of the MIP film using fluorescent spectroscopy.

Advantages / innovative aspects:

  • Functional monomer enable rapid and selective recognition of 2,4,6-trintrophenol in the presence of its structural analogues, as well as signal transdaction, due to fluoresce properties of the molecularly imprinted polymer.
  • Simle and fast method of preparing of recognition film, based on direct deposinion on the surface of the transducer of the chemosensor via electropolymerization.

Keywords:
2,4,6-trinitrophenol, nitroaromatic explosive, thiophene, electropolymerization, molecularly imprinted polymer, fluorescence chemosensor

Use:
The chemosensor is suitable for detrmination of 2,4,6-trinitrophenol in body fluids as well as determination of other nitroexplosive. Organic substances, Analytical chemistry, Inorganic chemistry, Diagnostics, Toxicology, Measuring sensors, Chemical techniques, Dangerous materials

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409656 – 30.09.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachments:
Graphs

OFFER no. 26/14

Title of the invention:
Novel spectrometric method of gold content determination in solutions and porous structures containing gold nanoparticles

Inventors:
Andryszewski Tomasz, Iwan Michalina, Kalińska Patrycja, Fiałkowski Marcin, Hołyst Robert

Field:
Analytical chemistry

Summary:
The invention discloses a novel spectrometric method, which enables a quantitative determination of the content of gold in porous materials as well as solutions containing gold nanoobjects. The method describes the digestion reaction, as well as the method of preparation and titer determination of reference samples, whose durability is at least six months. Moreover, the method is not limited by the type of organic or nonorganic ligands coating the gold nanoobjects’ surface. The scope of applicability of the method is 9 – 150 mg Au in the analyte.

Advantages / innovative aspects:

  • High durability of the calibrators solutions (6 months minimum)

    Keywords:
    Gold nanoparticles, gold content determination, Uv-Vis technic

    Use:
    Direct, quantitative method of gold content determination in aqueous solutions, porous structures and on surfaces of solid materials.
    Inorganic substances, Analytical chemistry, Methods and analytical apparatus, Chemical techniques, Optical Techniques

    State of the progress:
    Project completed

    Intellectual property rights:
    Patent application no. P-409626 – 29.09.2014 Poland

    Expected cooperation:
    contract of sale, licence agreement

OFFER no. 24/14

Title of the invention:
The microfluidic system to mixing, intended for preparing a blood sample for analysis, and the method of mixing fluids segments

Inventors:
Adam Samborski, Paweł Jankowski, Jacek A. Michalski, Judyta Węgrzyn

Field:
Analytical chemistry

Summary:
The subject of invention is a microfluidic system for preparing a blood sample for analysis by mixing the plasma with the segment of the analyte. The geometry of the mixer allows to good mixing of the test fluid segments (eg. plasma) with the segments of the analyte when they flow through the system one by one. The invention also provides a method of mixing fluids segments.

Advantages / innovative aspects:

  • A good mixing of the small segments of fluid (eg. plasma) with the segments of the analyte when they flow through the channel of microfluidic system one by one.
  • The possibility of medical diagnostics, the device accepted µL of whole blood (from a fingertip)

Keywords:
mixing, blood separation, diagnostics, microfluidics systems, point of care

Use:
Medical diagnostics, Method and Analitycal apparatus

State of the progress:
stage of prototype

Intellectual property rights:
Patent application no. P-409493 – 16.09.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Publication

OFFER no. 23/14

Title of the invention:
The microfluidic device to blood sedimentation, intended for preparing a blood sample for analysis, and the method of preparing blood samples for analysis

Inventors:
Adam Samborski, Paweł Jankowski, Jacek A. Michalski, Judyta Węgrzyn

Field:
Analytical chemistry

Summary:
The subject of invention is a microfluidic system for sedimentation, containing a sedimentation chamber, intended for preparing a blood sample for analysis. The system is designed to quickly obtain a sample of plasma from small amounts of blood (<30 µL) The subject of invention is also a method for preparing a plasma samples for analysis, wherein the microfluidic system is used. The microfluidic device could be applied in system that allow to perform Point of Care (POC) analysis.

Advantages / innovative aspects:

  • The possibility of medical diagnostics, the device accepted 27 µL of whole blood (from a fingertip)
  • Rapid blood analysis

Keywords:
blood separation, diagnostics, microfluidics systems, point of care, sedimentation

Use:
Medical diagnostics, Method and Analitycal apparatus

State of the progress:
stage of prototype

Intellectual property rights:
Patent application no. P-409492 – 16.09.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Publication

OFFER no. 21/14

Title of the invention:
A new artificial oligomer of ATATTT nucleobase sequence complementary to the promotor TATAAA sequence and its method of preparation, artificial strand of the promotor DNA containing this oligomer and its application for selective detection and determination of the TATAAA oligonucleotide

Inventors:
Agnieszka Pietrzyk-Le, Katarzyna Bartołd, Krzysztof Noworyta, Wojciech Lisowski, Mariusz Pietrzak, Małgorzata Wszelaka-Rylik, Włodzimierz Kutner, Francis D’Souza, Silvia Cauteruccio, Emanuela Licandro, Francesco Sannicolo, Patrizia R. Mussini

Field:
Analytical chemistry
Chemistry new materials

Summary:
The invention involves an artificial ATATTT (A-adenine, T-thymine) oligomer for recognition and selective determination of the promoter TATAAA sequence. The promoter is a short DNA sequence to which RNA polymerase binds in order to initiate transcription of a gene. Moreover, the invention involves the artificial double strand promoter sequence of DNA and its method of preparation as artificial hybridized oligomer ATATTT, i.e., molecularly imprinted polimer, MIP, obtained - in the presence of the TATAAA oligonucleotide - by potentiodynamic electropolymerization, on a conductive substrate. The DNA sequencing is essential in applications to genetic analysis. With the present invention, it is possible to prepare artificial DNA strands using electroactive functional monomers, substituted with nucleobases, based on the Watson-Crick nucleobase pairing.

Advantages / innovative aspects:

  • The devised ATATTT oligomer is easy to prepare in the form of a stable and chemically resistant thin polymer film.
  • This polymer can be deposited on the substrates with variety of shapes.
  • It allows for selective and reversible binding of the TATAAA oligonucleotide.
  • A chemosensor with a recognition film containing the ATATTT oligomer is highly selective and sensitive with respect to the TATAAA oligonucleotide as well as the detection limit is low appreciably.

Keywords:
artificial ATATTT oligomer, molecularly imprinted polymer, TATA box, TATAAA promotor sequence

Use:
Analytical chemistry, Biosensors, Clinical research, Diagnostics, Pharmacy and Medicines, Biomedical engineering, Oncology, Virology, Cell and molecular biology, Genetic engineering, Molecular modelling, Tests In vitro, Gene expression, Biocontrol

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409329 – 29.08.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement


OFFER no. 20/14

Title of the invention:
A new DNA probe containing thiophene derivatives and its method of preparation, a film of the conducting polymer molecularly imprinted with the use of these derivatives and the method of its preparation as well as application of this probe for selective detection and determination of the TATAAA oligonucleotide

Inventors:
Katarzyna Bartołd, Agnieszka Pietrzyk-Le, Tan-Phat Huynh, Zofia Iskierko, Krzysztof Noworyta, Marta Sosnowska, Wojciech Lisowski, Włodzimierz Kutner, Francis D’Souza, Silvia Cauteruccio, Emanuela Licandro, Francesco Sannicolo, Patrizia R. Mussini

Field:
Analytical chemistry
Chemistry new materials

Summary:
The invention involves an artificial DNA probe containing a conducting polymer film molecularly imprinted with thiophene derivatives and methods of preparation this probe and recognition ability of this probe as well as its application for selective detection and determination of the TATAAA oligonucleotide. Moreover, the invention relates to application of the chemosensor with the synthetic polymer, prepared by potentiodynamic electropolymerization, for recognition of single nucleotide polymorphism (SNPs) that is associated with genetic disease. The microarray technology uses chips with attached DNA sequences as probes for gene expression. There is a possibility of applications of our invention for fabrication of such next-generation DNA chips.

Advantages / innovative aspects:

  • The devised DNA probe is easy to prepare in the form of a stable and chemically resistant thin polymer film.
  • It can be deposited on the substrates with variety of shapes.
  • It allows for selective and reversible binding of TATAAA oligonucleotide.
  • A chemosensor with a recognition film made of this polymer exhibits high selectivity and high sensitivity with respect to TATAAA oligonucleotide, as well as appreciably low detection limit.

Keywords:
DNA probe, molecularly imprinted polymer, TATA box, TATAAA promotor sequence

Use:
Analytical chemistry, Biosensors, Clinical research, Diagnostics, Pharmacy and Medicines, Biomedical engineering, Oncology, Virology, Cell and molecular biology, Genetic engineering, Molecular modelling, Tests In vitro, Gene expression, Crop production, Cultivation, Animal production, Animal husbandry, Food additives, Food processing, Food technology, Food quality control

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409329 – 29.08.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement


OFFER no. 18/14

Title of the invention:
New bis(bithienyl) conducting polymer molecularly imprinted with carnosine and the method of its preparation and application for selective detection and determination of carnosine

Inventors:
Agnieszka Wojnarowicz, Piyush S. Sharma, Marta Sosnowska, Wlodzimierz Kutner, Francis D'Souza

Field:
Analytical chemistry
Chemistry new materials

Summary:
A new conducting polymer molecularly imprinded (MIP) with carnosine was devised and fabricated for the use as the recognition unit of a chemosensor for selective recognition, due to coordination and hydrogen bonds, and determination of carnosine. For that, functional monomers, vis. bis(2,2'-bithien-5-yl)-methylbenzo-18-crown-6 and p-bis(2,2'-bithien-5-yl)methylbenzoic acid were used. The carnosine recognition signals of the MIP film were transduced to analytical signals of the changes of capacity of the double layer using electrochemical impedance spectroscopy (EIS) under flow-injection analysis conditions (FIA). The limit of detection (LOD) was as low as 20 µM indicating that the chemosensor is suitable for detrmination of carnosine in body fluids

Advantages / innovative aspects:

  • Functional monomers enable rapid and selective recognition of carnosine in presence of its structural analogues, as well as signal transdaction, due to conducting properties of the molecularly imprinted polymer prepared with their use.
  • Simle and fast method of preparing of recognition film, based on direct deposinion on the surface of the transducer of the chemosensor via electropolymerization.

Keywords:
molecularly imprinted polymer, electropolymerization, carnosine, electrocemical impedance spectroscopy, piezomicrogravimetry

Use:
Plastics, Polymers, Analytic chemistry, Organic chemistry, Biosensors, Diagnostics, Quality control

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-409325 - 29.08.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachments:
Graphs

OFFER no. 17/14

Title of the invention:
Platform for testing of chemicals and microorganisms via surface enhanced Raman spectroscopy and method of its preparation.

Inventors:
Evelin Witkowska, Tomasz Szymborski, Jacek Waluk, Agnieszka Michota-Kamińska

Field:
Analytical chemistry
Environmental chemistry

Summary:
The present invention provides a platform for the testing of chemicals and microorganisms via surface enhanced Raman spectroscopy and method of preparation of this platform. The present invention discloses a new surface which can be used for the analysis in Surface-enhanced Raman spectroscopy (SERS) based on a layer of polymeric nanofibers made with Forcespinning technique with highly developed surface coated with gold.

Advantages / innovative aspects:

  • The mat produced by the Forcespinning method consists of two layers: the lower layer is the base consisting of microfibers, and an upper part of the platform consisting of nanofibers.
  • Forcespinning method allows to obtain a wide range of fibers from polymers, including those with high melting point.

Keywords:
SERS platform, bacteria, microorganisms, microfibers, nanofibers

Use:
Clinical research, Bacteriology, Microbiology, Toxicology, Biocontrol, Quality and safety of food, Research methods, Microbiology of food, Quality control,Safety of production, Biodiversity, Ecology, Environmental engineering, Natural disasters, Measurements of pollution, Soil contamination, Water pollution, Wastewater

State of the progress:
stage of prototype

Intellectual property rights:
Patent application no. P-409210 – 19.08.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 14/14

Title of the invention:
The method of elecrochemical deposition of metal nanoparticles on surface, the surface obtained by this method and the use thereof.

Inventors:
M. Księżopolska-Gocalska, W. Michałowicz, M. Siek, J. Niedziółka-Jönsson, M. Opałło, R. Hołyst

Field:
Analytical chemistry
Chemistry new materials
Chemical technology

Summary:
The invention offers a method for preparing a surface covered with metal nanoparticles, a platform obtained by this method and the use thereof in surface enhanced Raman spectroscopy (SERS). The innovation of this method is a combination of a simple electrochemical method with a new way of electrolyte preparation whose the key condition is control of a given solution's temperature. The obtained surface is characterized by homogeneous distribution of nanoparticles of size 50 - 400 nm. These platforms make it possible to detect chemical compounds adsorbed from very dilute solutions and at the same time have good repeatability of the signals in the SERS spectra.

Advantages / innovative aspects:

  • New, simple and fast method for preparing the electrolyte.
  • Low cost of the substrates produced.
  • High enhancment factor (EF) of substrates makes it possible to detect chemical compounds from very dilute solutions.
  • Good repeatability of signals in SERS spectra from surface of single platform and throughout the series.
  • Homogeneous distribution of metal nanoparticles on the surface.

Keywords:
SERS platform, Raman, nanoparticles, electrochemistry, temperature of solution, repeatability

Use:
Planning and prototyping, Cleaning and preparation of surface, Control of processes, Chemical engineering, Electric materials, Analytical chemistry, Mikro. and Nano.technologies, Measuring sensors, Measurements of pollution, Water pollution, Wastewater

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent application no. P-408785 – 09.07.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 11/14

Title of the invention:
Thiophene derivatives and method of producing thereof, recognition film of molecularly imprinted conducting polymer produced using thiophene derivatives, method of producing thereof, as well as its use for selective detection and determination of inosine

Inventors:
Zofia Iskierko, Marta Sosnowska, Piyush S. Sharma, Francis D'Souza, Tiziana Benincori, Krzysztof Noworyta

Field:
Analytical chemistry
Chemistry new materials
Chemical technology
Environmental chemistry

Summary:
The invention encompases a chemical compound p-bis(2,2'-bithien-5-yl)-methylobenzoic-2-(cytosin-1-yl)ethyl and the method of its synthesis. Moreover, the invention encompasses recognition polymer film molecularly imprinted with inosine obtained by electrochemical polymerization of the abovementioned compound and 2,2'-bithiopheno-5-boronic acid used as functional monomers, as well as 2,4,5,2',4',5'-hexa(thiophen-2-yl)-3,3'-bithiophen used as cross-linking monomer. The invention encompasses also method of preparation of the recogniton polymer film and its application as recognition unit of the piezomicrogravimmetric and extended-gate field-effect transistor chemosensors for detection and determination of inosine, especially in body fluids.

Advantages / innovative aspects:

  • High selectivity
  • High detectability
  • Easy to prepare
  • Possibility of miniaturisation

Keywords:
inosine, molecularly imprinted polymers, chemosensors, piezomicrogravimmetry, extended-gate field-efffect-transistors, electrochemical sensors, biomarkers,

Use:
Plastics, Polymers, Organic substances, Analytical chemistry, Organic chemistry, Sensor technologies, Diagnostics, Sensors, Chemical techniques

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-408507 – 11.06.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 9/14

Title of the invention:
Polymeric recognition films fabricated using molecular imprinting and the method of their fabrication as well as their application for selective detection and determination of D-arabitol and L-arabitol

Inventors:
Marcin D±browski, Piyush Sindhu Sharma, Krzysztof Noworyta, Witold Adamkiewicz, Zofia Iskierko, Matthias Heim, Alexander Kuhn, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials

Summary:
Chemical sensors for selective and sensitive detection and determination of D-arabitol and L-arabitol, especially in body fluids, such as blood plasma, urea, etc., were fabricated. These chemosensors could be used for early diagnosis of fungal infections caused by fungi from the Candida family. Herein, macroporous thin films of conducting molecularly imprinted polymers (MIPs) of bithiophenes were used as recognition units of the chemosensors. Two different platforms of signal transduction were successfully applied. A quartz crystal microbalance was used in one and an extended-gate field-effect transistors (EG FET) in the other.

Advantages / innovative aspects:

  • Chemical sensors used for sensing and determination of arabitol are attractive alternative to conventional analytical methods basing on chromatography and fluorescence.
  • In comparison to chromatographic and fluorescence methods the chemical sensors does not require expensive laboratory instrumentation operated by highly qualified personnel.
  • Chemical sensors used for determination of arabitol are simpler, more rapid, more convenient and can be used by non-qualified personnel or patient at home.
  • Chemical sensors are composed of molecularly imprinted polymers (MIPs), artificial receptors materials, that in comparison to their biological counterparts are much more resistant to harsh chemical environment; they perform their receptor properties for long time, therefore they can be stored for long period; they can be fabricated in various forms and their manufacturing is cheap
  • Using nanobeads-generated macroporosity technology specific surface of the recognition unit was developed and as a result the sensitivity and the detectability of the chemosensors was enhanced.
  • Detectability of the chemosensors is well above the physiological concentration of arabitol in urine and cerebrospinal fluid and is comparable to the concentration of arabitol in blood plasma.
  • Selectivity of the fabricated chemosensors with respect to common interferences was high.

Keywords:
chemical sensors, molecularly imprinted polymers, D-arabitol, L-arabitol, sugars, carbohydrates, nanobeads, macroporosity, surface development, candidiasis diagnosis, medical diagnosis, medical analytics, analytical chemistry, Candida sp.

Use:
A chemical sensors for selective and sensitive detection and determination of D-arabitol and L-arabitol, especially in body fluids, such as blood plasma, urea, etc. could be used for early diagnosis of fungal infections caused by fungi from the Candida family.
As clinical statistics show, the number of invasive fungal infections has rapidly been growing for recent decades. This growth is due to medical advancements in the cancer treatment as well as the organ and bone marrow transplantations. The most common pathogens responsible for fungal infections, isolated from blood, are prevailingly Candida yeasts. Fast and unambiguous diagnosis of these infections is crucial for successful therapy. Increased mole ratio of D-arabitol to L-arabitol in the blood and urine samples indicates infections even at an early stage. Currently used protocols of determination of arabitol employs GC-MS requiring an expensive laboratory instrumentation and trained personel. Therefore, this diagnostic method is inaccessible for many hospitals. Hence, the proposed herein MIP chemosensors for selective determination of D-arabitol and L-arabitol may find its use in clinical laboratory practice.
Moreover, the developed protocol of molecular imprinting can be used for fabricating chemosensors for other sugar analytes.
Carbohydrates are biological compounds essential in nutrition, metabolism, and the cell structure. They are physiologically active playing a fundamental role in the birth control, cell differentiation, and immunity. Because of these important functions, there is a great demand to develop methods for in-situ carbohydrate sensing and determination in clinical samples.
Chemicals, Plastics, Polymers, Organic substances, Plastics and synthetic rubber, Analytical chemistry, Organic chemistry, Diagnostics, Methods of research of food, Control of the food quality

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-408290 – 22.05.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment:
Complex
Macroporosity

OFFER no. 8/14

Title of the invention:
New bis(2,2'-bithienyl)methane derivative and a method of its preparation as well as the film of a molecularly imprinted polymer, method of its preparation and application for selective determination of nicotine

Inventors:
Tan-Phat Huynh, Chandra Bikram K.C., Marta Sosnowska, Janusz Sobczak, Vladimir N. Nesterov, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials

Summary:
New conducting molecularly imprinted polymer (MIP) for selective recognition, due to the coordination and hydrogen bonds, and determination of nicotine, was devised and fabricated as a recognition unit of a chemosensor. For that, new functional monomers, vis., 2,9,16,23-tetraphenyl[4-methyl-bis(2,2'-bithienyl)]phthalocyaninato Zinc(II), and bis(2,2'-bithienyl)-[4-(2-hydroxyethoxy)phenyl]methane, were designed and synthesized. For nicotine determination, simultaneous chronoamperometry (CA) and piezoelectric microgravimetry (PM) measurements were performed under flow-injection analysis (FIA) conditions. The limit of detection (LOD) of the CA and PM chemosensing as as low as 40 and 12 µM, respectively, indicating that the chemosensor is suitable for practical determination of nicotine in body fluids. Moreover, selectivity of the CA and PM chemosensing with respect to a common interference, like cotinine, was as high as 15.5 and 8.8, respectively

Advantages / innovative aspects:

  • The functional monomers enable selective determination of nicotine in the presence of its anologues as well as signal transduction due to conducting properties of the molecularly imprinted polymer prepared with their use.
  • Simple and fast preparation method of the recognizing material by direct deposition on surface of the transducer of the chemosensor via electropolymerization.

Keywords:
molecularly imprinted polymer, conducting polymer, nicotine, cotinine, myosmine, electrochemical polymerization, electropolymerization

Use:
Plastics, Polymers, Sensors, Chemical techniques, Analytical chemistry, Biosensors, Toxicology

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-407167 – 13.02.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment:
Graph

OFFER no. 7/14

Title of the invention:
Colorimetric sensor for detection and/or identification of viruses and bacteriophages especially adenoviruses and T7 bacteriophages

Inventors:
Adam Leśniewski, Marcin Łoś, Martin Jönsson-Niedziółka, Anna Krajewska, Katarzyna Szot, Joanna Łoś, Joanna Niedziółka-Jönsson

Field:
Analytical chemistry
Chemistry new materials

Summary:
The subject of the invention is the colorimetric sensor for detection and/or identification of viruses and bacteriophages especially adenoviruses and T7 bacteriophages. The sensor is based on gold nanoparticles modiffied with the groups that allow for covalent binding of the anti virus/phage antibodies to the nanoparticles' surface, favourably amine groups. The invention also includes the method of detection and/or identification of viruses and bacteriophages with the use of described sensor, and it's application.

Advantages / innovative aspects:

  • sensor is selective against M13 bacteriophage
  • using the antibody-antigen interaction alows us for the detection of biologically inactive viruses
  • the described method is of higher precision than classic ones

Keywords:
colorimetric sensor, bacteriophage, T7, adenovirus, antibody

Use:
Analytic chemistry, Diagnostics, Virology, Microbiology, Mikro. and Nanotechnology, Measuring sensors, Chemical techniques

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-407090 – 05.02.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 6/14

Title of the invention:
The method of determination of ligand-macromolecule interaction

Inventors:
Aldona Majcher, Anna Lewandrowska, Robert Hołyst

Field:
Analytical chemistry

Summary:
The subject of invention is method for determination of the association constant of macromolecule-ligand complexes at high flow rates of a carrier phase (31 cm/s). In the experiments we use typical flow injection equipment consisting of pump, autosampler, UV-Vis detector and long, thin, coiled capillary. In the injection point we introduce ligand, macromolecule and ligand with macromolecule into the capillary. At the end of the capillary detector monitors the concentration distribution of the analyte. From the width of the concentration distribution we calculate the value of the diffusion coefficient. Based on the diffusion of free and bound ligand we are able to determine the value of the association constant fast (less than 3 minutes) and precisely.

Advantages / innovative aspects:

  • The method is fast
  • The sample preparation is easy and fast
  • We can change the thermodynamic properties of the process such as ionic strength, viscosity, pH etc.
  • The method is characterized by high precision and repeatability of the measurements
  • We are able to study different types of substances

Keywords:
association constant, diffusion coefficient, ligand-macromolecule interaction

Use:
Pharmaceuticals, Analytic chemistry, Physics of fluids, Pharmacy and Medicines

State of the progress:
stage of development

Intellectual property rights:
Patent application no. P-407087 - 05.02.2014 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 5/14

Title of the invention:
Composite material, method for production and use thereof

Inventors:
Jan Paczesny, Katarzyna Wybrańska, Joanna Niedziółka-Jönsson, Monika Wadowska, Robert Hołyst, Marcin Fiałkowski

Field:
Nanotechnology
Chemistry new materials

Summary:
The invention relates to a composite material, process for its preparation and its use. In particular, the method is carried out in a two-step procedure.
- In a first step the surface of the object, which is the template for the final product is modified. The selected area should be hydrophilic and should include groups such as –OH or –COOH. Controlled polymerization of oxoborates in the presence of metallic nanoparticles, and said physical object whose surface is to be modified, results in the formation of a nanocomposite material comprising metallic nanoparticles and polyoxoborates. The first step of surface modification is described in patent PCT/EP2013/075709, P-406393 and P-404257.
- In the second step the product of the first step undergoes calcination (in high temperature or as a result of rapid burn) to remove the template. The material according to the invention is electrically conductive and is active in electrochemical applications. It can be used for the construction of the thermistor with a high electrical resistance.

Advantages / innovative aspects:

  • The invention offers a composite material, which is electrically conductive and heat-sensitive.
  • The invention includes a method for preparing composite materials, characterized in that it comprises the following steps: a). nanocomposite deposition of metal nanoparticles, especially gold, silver, copper, nickel, cobalt or mixtures thereof, and oxoborates at the hydrophilic surface as a template to form a modified surface, and then b) removing the template of by calcination or deflagration to give a composite material.
  • The invention includes the use of this composite material in electrochemistry and electronics, in particular for production of electrodes in electrical and electronic systems, such as thermistors.

Keywords:
nanocomposite, termosensitive material, conductive material

Use:
Electronic Nanoengineering, Semiconductors, Composites, Properties of materials, Resistance, Corrosion, Paper technology, Electric materials, Special Substances, Solar power (photovoltaic cells), Unconventional or alternative energy sources, Inorganic chemistry, Thermal methods

State of the progress:
stage of prototype

Intellectual property rights:
Patent application no. P-407008 – 30.01.2014 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachments:
- Preparation
- Thermistor

OFFER no. 4/14

Title of the invention:
Novel asymmetrical spirotruxenes, method for production and use thereof in particular in organic electronics and optoelectronics

Inventors:
Michał Maciejczyk, Marek Pietraszkiewicz, Krzysztof Górski

Field:
Nanotechnology
Chemistry new materials

Summary:
The invention provides novel asymmetrical spirotruxenes, a process for preparation thereof and use thereof, especially in organic electronics and optoelectronics.

Advantages / innovative aspects:

  • novel asymmetrical spirotruxene derivatives
  • improved solubility of compounds containing spirocyclic groupings due to modification of the systems with alkyl groups
  • simple sequential method for synthesis of a novel group of compounds

Keywords:
truxene, spirotruxene, asymmetrical spirotruxene

Use:
Organic chemistry, Organic substances

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-407007 – 30.01.2014, Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 3/14

Title of the invention:
Novel asymmetrical heterotruxenes, method for production and use thereof in particular in organic electronics and optoelectronics

Inventors:
Michał Maciejczyk, Marek Pietraszkiewicz, Krzysztof Górski

Field:
Nanotechnology
Chemistry new materials

Summary:
The invention provides novel asymmetrical heterotruxenes, a process for preparation thereof and use thereof, especially in organic electronics and optoelectronics.

Advantages / innovative aspects:

  • novel asymmetrical heterotruxene derivatives,
  • improved solubility of heterotruxenes due to developed simple possibility of modification with solubilising groups,
  • simple sequential method for synthesis of a novel group of compounds,
  • the developed method allows incorporating various heteroatoms into the truxene structure at 5,10,15-positions, what makes it possible to modify the material properties with relation to the intended use.

Keywords:
truxene, heterotruxene, asymmetrical heterotruxene

Use:
Organic chemistry, Organic substances

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-407006 – 30.01.2014, Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 2/14

Title of the invention:
Way of the carbon electrode preparation, electrode prepared in this way and its application in tiocholine detection

Inventors:
Anna Celebańska, Adam Le¶niewski, Marcin Opałło, Joanna Niedziółka-Jönsson

Field:
Analytical chemistry
Chemistry new materials

Summary:
The object of the inventions is carbon electrode, its preparation and application for thiocholine detection. Carbon nanoparticulate film electrodes were prepared by electrophoretic deposition of phenylsulphonate functionalized carbon nanoparticles. The modified electrode has much bigger electroactive area than indium tin dioxide substrate. The amount of the deposited material and therefore magnitude of the current corresponding to slow electrode reactions can be controlled by electrophoresis parameters. The modified electrode exhibits significant electrocatalytic activity towards thiocholine oxidation. It was used for its sensitive determination with a wide (0.5 - 2000 µM) linear range and the limit of detection 0.5 µM.

Advantages / innovative aspects:

  • New, high mechanical stable electrode material,
  • Electrophoretic deposition technique allow to control of electrochemical properties of obtained material,
  • Fast and very easy way of electrode preparation,
  • Possible of different shape surface covering
  • Cheap material,
  • The electrode exhibits excellent electrocatalytic behavior towards thiocholine detection,
  • The electrode is a good substrate for organophosphate biosensors preparation.

Keywords:
Carbon nanoparticles, electrphoretic deposition, thiocholine, electrode, sensor, biosensor for pesticide

Use:
Analytical chemistry, Biosensors, Bacteriology, Diagnostics, Pesticides, Beverages, Quality and safety of food, Measuring sensors, Measurements of pollution, Water pollution, Wastewater

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-406915 - 23.01.2014 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement


Attachement

OFFER no. 1/14

Title of the invention:
The platform and its use for the detection and / or identification of microorganisms, especially bacteria, via the technique of surface enhanced Raman effect and a method for the deposition of these microorganisms on produced platforms

Inventors:
Tomasz Szymborski, Evelin Witkowska, Witold Adamkiewicz, Jacek Waluk, Agnieszka Michota - Kamińska

Field:
Analytical chemistry

Summary:
The invention is a platform and its use for the detection and / or identification of microorganisms, especially bacteria, via the technique of surface enhanced Raman spectroscopy (SERS) and a method for depositing these microorganisms on produced platforms. In particular, the invention includes a method of depositing micro-organisms, particularly bacteria, suspended in a liquid / liquid / solution (e.g., blood, plasma, water, waste water), on the polymer mat of nano- and micrometer sized polymer fibers coated with metal, and a platform for the measurement of surface enhanced Raman made by this method.

Advantages / innovative aspects:

  • The method enables the deposition of bacteria from solutions with their lower content, increasing the concentration of bacteria in a specific area of the platform.
  • The SERS platform acts also as a filter, therefore it shortens the procedure and prevents contamination of the sample.

Keywords:
detection of bacteria, SERS, blood, substrates for SERS technique, the deposition of bacteria

Use:
Microbiology, Bacteriology, Diagnostics, Measurements of pollution

State of the progress:
stage of prototype

Intellectual property rights:
Patent application no. P-406900 – 22.01.2014 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 35/13

Title of the invention:
Method for surface modification with nanocomposites, nanocomposite material and the use thereof

Inventors:
Katarzyna Wybrańska, Jan Paczesny, Marcin Fiałkowski, Robert Hołyst

Field:
Nanotechnology
New functional materials

Summary:
The invention relates to a method for surface modification with nanocomposites containing metallic nanoparticles. The method is fast, effective and versatile. Nanocomposite may be deposited on both hydrophilic and hydrophobic surfaces. It means that different materials can be modified (i.e. glass, cotton, wood, natural and synthetic polymers, hydrogels). Modified materials displays strong antibacterial activity towards both Gram-positive and Gram-negative bacteria strains. Toxicity tests showed that – in spite of its antiseptic properties – the nanocomposite is harmless for mammalian cells. Finally, the method of surface modification we described uses mild, environmentally friendly fabrication conditions. Thus, it offers a facile approach for obtaining durable non-toxic antiseptic coatings for biomedical applications, but may also be used in other sectors: food, cosmetics and/or textile industry.

Advantages / innovative aspects:

  • Versatility – different materials can be modified (both hydrophilic and hydrophobic)
  • The modification proces is fast and simple and there is no need of any harsh condition to be used
  • The amount of nanoparticles attached to the surface is precisely controlled
  • The method is ecologically friendly and inexpensive
  • The product of the modification has homogenous and durable nanocoting
  • Modified materials displays strong antibacterial activity whilst being harmless towards mammalian cells

Keywords:
nanocoatings, nanoparticles, antiseptic, biocompatible

Use:
Industrial technologies: Coating, Packing: Packaging materials, Construction technologies: Building materials, Material technologies: Composites, Properties of materials, Resistance, Corrosion, Chemical technologies: Inorganic Substances, Special Substances, Textile technologies: Finishing, Membrane and filtration technologies, Mikro. and Nano.technologies, Bacteriology, Biomedical engineering, Biology and Biotechnology: Tests In vitro, Toxicology, Agriculture: Biocontrol, Pesticides, Packing of food, Quality and safety of food: Microbiology of food

State of the progress:
stage of development

Intellectual property rights:
Patent applications no. P-404257 – 10.06.2013 – Poland, P-406393 - 05.12.2013 - Poland, PCT/EP2013/075709 - 05.12.2013 - World Intellectual Property Organization

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Photo

Presentation

OFFER no. 34/13

Title of the invention:
Method of obtaining a platform for tests on chemical substances using surface-enhanced Raman spectroscopy technique and a platform obtained by this process

Inventors:
Elżbieta Guziewicz, Dmytro Snigurenko, Krzysztof Kopalko, Evelin Witkowska, Tomasz Szymborski, Agnieszka Michota-Kamińska

Field:
Chemistry new materials

Summary:
The present invention is related to the process of preparation of a platform for tests on chemical substances using surface-enhanced Raman spectroscopy technique and to the platform obtained by this process. More specifically, the present invention reveals a new surface for the analysis of surface enhanced Raman spectroscopy (SERS) based on highly developed zinc oxide surface (obtained by atomic layer deposition technique, ALD) covered with gold.

Advantages / innovative aspects:

  • High Raman enhancement factor,
  • Small amount of defects on the surface,
  • Highly developed surface,
  • Wide range of applications

Keywords:
Raman, SERS, ALD, surface-enhanced Raman spectroscopy, atomic layer deposition

Use:
Industrial technologies, surface treatment, material technologies, properties of materials, Micro. and Nano. technologies

State of the progress:
stage of prototype

Intellectual property rights:
Patent application no. P-406026 – 13.11.2013 – Poland
Co-owner Institute of Physics of the Polish Academy of Sciences

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 32/13

Title of the invention:
Microfluidic system for automatic formation of lipid membranes with various and controllable size and its application

Inventors:
Tomasz Kamiński, Magdalena Czekalska, Piotr Garstecki

Field:
Analytical chemistry

Summary:
The invention comprises the microfluidic system that enables the reconstitution of stable and reproducible synthetic lipid bilayers. The lipid bilayer is formed between aqueous droplets submerged in oil, when the phospholipid molecules self-organize at their interface. Droplet microfluidics is a technology that would exclude the manual handling of fluids and enable replicable, high-throughput measurements. Thanks to the microfluidic control over the droplets it was possible to exchange them in an automated way. Additionally the device has the ability of active control over the bilayer area and change of protein concentration. This feature might be very useful in biophysical experiments.

Advantages / innovative aspects:

  • Innovation comprises the microfluidic system that combines the technologies of passive (use of hydrodynamic traps) and active (use of external valves) handling of droplets on a microfluidic chip. This technological synergy ensures that operation on droplets are conducted according to predefined protocol.
  • The lipid membrane has an exceptional stability that supports long-term measurements.
  • The device has an ability of controllable manipulation over the area of bilayer and thus change of concentration of membrane proteins.
  • Microfluidic system has an advantage of minute consumption of reagents.

Keywords:
droplet microfluidics, droplet interface bilayers, membrane proteins, biophysics

Use:
Analytic chemistry, Biochemistry and Biophysicist, Enzymology and Engineering of protein, Tests In vitro, Mikro and the Nanotechnology

State of the progress:
stage of development

Intellectual property rights:
Patent application no. P-405819 – 29.10.2013 – Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 31/13

Title of the invention:
A microfluidic reactor especially for carrying out chemical reactions

Inventors:
Tomasz Szymborski, Paweł Jankowski, Piotr Garstecki

Field:
Chemical technology

Summary:
The invention relates to microfluidic reactor for preparing chemical reactions. This reactor comprises at least two plates made of polytetrafluoroethylene (PTFE), and / or derivatives, the plates are connected to each other mechanically. In one of the plates are milled channels with dimensions in the micrometer scale in such a way that after the mechanical joining of the both plates, the gap between plates became a microfluidic channel. A microfluidic reactor is designed for organic and/or organo-metallic synthesis, and everywhere where aggressive solvents are used.

Advantages / innovative aspects:

  • The method enables the joining two plates made of Teflon (PTFE), which through its chemical resistance is ideal for conducting organic reactions in aggressive solvents. The connection is made mechanically, without the use of heat or adhesive substances.,
  • The method allows easy disassembling of the reactor which allows easy cleaning of the channels and, consequently, the reactor can be used repeatedly,
  • In the both plates we can place holes for optical fibers, therefore the organic synthesis can be monitored in situ via UV/Vis spectroscopy or any other spectroscopic methods which involves use of fiber optics.

Keywords:
microfluidics, organic synthesis in microscale, microfluidic reactor, teflon

Use:
Chemical engineering, Analytical chemistry, Organic chemistry

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent application no. P-405651 – 15.10.2013 – Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 30/13

Title of the invention:
A method of joining of the plates made of polymeric materials, in particular high modulus polymeric materials and a microfluidic system formed by this method

Inventors:
Tomasz Szymborski, Paweł Jankowski, Piotr Garstecki

Field:
Chemical technology

Summary:
The invention is a method of connecting plates made of polymeric materials, in particular high Young modulus and a microfluidic system formed by the method. In particular, the invention includes a microfluidic system, intended for carrying out chemical reactions or other processes requiring microscale flow, comprising at least two plates made of polymeric materials combined with 'latch' milled in one of the plates and a complementary channel to match the 'latch' milled in the second plate. The method allows preparing chip with two plates of polymer like Teflon (PTFE), it also allows easy and independent chemical modification of both parts of the chip and use two different materials as the top and bottom of the chip.

Advantages / innovative aspects:

  • The method enables joining of two polymer plates that are not possible to connect using the standard methods (by thermal method, surface chemical modification or plasma), such as teflon (PTFE).
  • The method makes possible the connection of two polymer plates that are made of different materials (e.g., polycarbonate / polypropylene, PTFE / PMMA, etc.).
  • Plate before merging can be separately chemically modified (e.g., hydrophilic and hydrophobic), what makes channel hydrophobic on the bottom, and hydrophilic on the top, which is unattainable with normal methods of joining.
  • The method permits sputtering gold electrodes on one of the plates, after merging together with second plate, chip may be used for electrochemistry or/and analytical chemistry.

Keywords:
microfluidics, analytical chemistry in microscale, biosensor, microfluidic chip

Use:
Biomedical engineering, Analytical chemistry, Organic chemistry, Biosensors, Diagnostics, Toxicology

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent application no. P-405650 – 15.10.2013 – Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 27/13

Title of the invention:
Hydrogen detector

Inventors:
Marek Knor, Tomasz Jaroch, Ryszard Duś, Robert Nowakowski

Field:
Analytical chemistry
Environmental chemistry

Summary:
The invention concerns optical detector of hydrogen in gaseous environment. It comprises active element, light source and photodetector. This device detects changes of optical properties of thin europium film caused by its reaction with hydrogen and the formation of europium dihydride. The reaction is accompanied by the transition of the light-reflecting original metal into a transparent semiconductor of orange coloration. As a consequence the light absorbance of the active film decreases (transmittance increases) with hydrogen uptake. Since, the average stoichiometry of europium hydride in the film (H/Eu atomic ratio) depends on the partial pressure of hydrogen in the gaseous environment, the measured optical properties of the film can be correlated with the actual concentration of hydrogen in gaseous atmosphere.

Advantages / innovative aspects:

  • application of europium as active metal in optical hydrogen detector;
  • new system of detection based on the intensity changes of light reflected from the active layer;
  • application of thin layer of active metal of the thickness between 10-60 nm;
  • new method of estimation of hydrogen concentration in gas environment based on kinetics of the intensity changes of light reflected from the active layer;
  • miniaturization of the device.

Keywords:
hydrogen detector, rare earth metals, metal hydride, reversible metallic mirrors.

Use:
Inorganic chemistry, Solid-state physics, Sensor Technology, Micro and Nanotechnologies, Protection of the man and of the environment: Safety, Risk estimation

State of the progress:
stage of prototype

Intellectual property rights:
Patent application P-405384 – 18.09.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

Links to the publications:
1, 2

OFFER no. 26/13

Title of the invention:
Microfluidic system for automatic formation of lipid membranes and test of membrane protein activity

Inventors:
Magdalena Czekalska, Tomasz Kamiński, Piotr Garstecki

Field:
Analytical chemistry

Summary:
The invention comprises the microfluidic system that enables the reconstitution of stable and reproducible synthetic lipid bilayers. The lipid bilayer is formed between aqueous droplets submerged in oil, when the phospholipid molecules self-organize at their interface. One of the possible applications of this method is a high-throughput screening of putative agents interacting with membrane proteins. Droplet microfluidics is a technology that would exclude the manual handling of fluids and enable replicable, high-throughput measurements. Thanks to the microfluidic control over the droplets it was possible to exchange them in an automated way and perform a rapid screen of different concentrations of an membrane protein inhibitors.

Advantages / innovative aspects:

  • Innovation comprises the microfluidic system that combines the technologies of passive (use of hydrodynamic traps) and active (use of external valves) handling of droplets on a microfluidic chip. This technological synergy ensures that operation on droplets are conducted according to predefined protocol.
  • The lipid membrane has an exceptional stability that supports long-term measurements.
  • The measurements of the activity of membrane proteins are highly reproducible and conducted with so far unattainable efficiency.
  • Microfluidic system has an advantage of minute consumption of reagents.

Keywords:
Droplet microfluidics, Droplet Interface Bilayers, membrane proteins, high-throughput screening

Use:
Analytical chemistry, Antibiotics, Pharmacy and Medicines, Biochemistry and Biophysicist, Enzymology and Engineering of protein, Tests In vitro, Micro and Nanotechnology

State of the progress:
stage of development

Intellectual property rights:
Patent application no. P-405321 – 12.09.2013 – Poland
Patent application no. FI 20145802 – 12.09.2014 - Finland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Film

Attachment

OFFER no. 25/13

Title of the invention:
Silicate matrix, its preparation and application

Inventors:
M. Opałło, A. Celebańska, E. RoĽniecka, O. Krysiak

Field:
Chemistry new materials

Summary:
The object of the inventions is silicate matrix, its preparation and application. This matrix is made by mixing of two sol-gel precursors including the basic one and second, which modify the matrix with positive or negative charge. this matrix found application for immobilization of carbon nanoparticles, carbon nanotubes or biological molecules, e.g. enzymes, what allows to use it as an element of sensor do thiocholine, dopamine or organophosophate pesticide. This applications are the part of the invention as well

Advantages / innovative aspects:

  • Stable and reproducible silicate matrix
  • The specialist equipment is not required for matrix preparation
  • Fast and cheap way of immobilization
  • Excellent matrix for biological molecules immobilization
  • Excellent matrix for carbon nanobjects immobilization, like nanotubes, nanoparticles
  • Positive charge matrix causes stabilizations of immobilized negative charged nanoobjects

Keywords:
Silicate matrix , immobilization, enyzme, acetlcholinesterase, sensor, biosensor, pesticide, thiocholine, dopamine, carbon nanoparticles, carbon nanotubes

Use:
Analytical chemistry, Diagnostics, Biomedical engineering, Enzymology and Engineering of protein, Toxicology, Pesticides, Safety of production, Measuring sensors, Water pollution, Wastewater

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-405269 – 09.09.2013- Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 24/13

Title of the invention:
Carbon multilayer electrode and its application

Inventors:
M. Opałło, A. Celebańska, M. Filipiak, J. Jędraszko, A. Le¶niewski, M. Jönsson-Niedziółka

Field:
Chemistry new materials

Summary:
The object of the inventions is carbon multilayer electrode and its application for thiocholine detection. The electrode was prepared by layer-by-later technique with subsequent immersions of electrode substrate into suspension of positively charged carbon nanotubes modified with polymer, and negatively charged carbon nanoparticles. The layers formed due to electrostatic attractions of nanoobjects functionalities. This electrode exhibits good catalytic properties toward thiocholine oxidation and detection, what is impotent from biosensors construction point of view, and determination of enzyme, acetcholinesterase activity.

Advantages / innovative aspects:

  • New, stable electrode material,
  • Layer-by-layer technique allows for controlling of electrochemical properties of obtained material,
  • Fast and easy way of electrode preparation, without using special equipment,
  • Cheap material,
  • The electrode exhibits excellent electrocatalytic behavior towards thiocholine detection,
  • The electrode is a good substrate for organophosphate biosensors preparation.

Keywords:
Carbon electrode, layer-by-layer, sesor, thiocholine, biosensor for pesticide

Use:
Analytical chemistry, Bacteriology, Diagnostics, Pesticides, Beverages, Quality and safety of food, Measuring sensors, Measurements of pollution, Water pollution, Wastewater

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-405159 - 29.08.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 22/13

Title of the invention:
System for the photocatalytic degradation of volatile organic compounds

Inventors:
Juan Carlos Colmenares Quintero, Paweł Lisowski

Field:
Chemical technology, Environmental chemistry

Summary:
A system for investigation of photocatalytic degradation of volatile organic air pollutants. The system comprises a photoresistor designed to make use to the maximum extent of the active surface of the photocatalyst and light used for activation of this catalyst. The system offers the measurement of reaction temperature, intensity of light of the used lamps as well as thermostating the process due to use of a simple lamp cooling system. The use of an in-house constructed reflector in this system improves maximally the effectivity of utilizing the light for the photocatalytic tests.

Advantages / innovative aspects:

  • Innovative reactor design allows for maximal utilizing the light energy of the lamps used.
  • Very effective method of utilizing the light energy of the lamps used.
  • Very high degree of degradation of organic air pollutants.
  • High selectivity towards complete mineralization of volatile organic compounds (to carbon dioxide and water).
  • Easy handling and innovative design allows following important data during the photocatalytic reaction (e.g., reaction temperature, exposure intensity).

Keywords:
photocatalysis, pure air, volatile organic compounds, photoreactor, degradation

Use:
Air pollution, Chemical engineering, Producing apparatus, Solar power (photovoltaic cells)

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-405094 - 19.08.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 21/13

Title of the invention:
Modification method of mechanical properties of titanium-aluminum alloy and an alloy obtained by this way

Inventors:
Marek Tkacz

Field:
Chemistry new materials, Chemical technology

Summary:
Titanium and its alloys are conventional materials having unique mechanical properties. The only feature of titanium alloys that is disadvantageous in their broader application, is their low malleability, i.e., brittleness. This invention provides modification of their properties by hydrogenation, causing a phase transition from the hexagonal one (brittle) to the cubic one (plastic). An alloy obtained that way, in addition to the change of malleability, features almost doubled modulus of longitudinal elasticity ranging from 250 to 300 GN/m2 and the density less by 30%, what makes the devices manufactured from this material more resistant and lightweight.

Advantages / innovative aspects:

  • improvement in plasticity
  • improvement in elasticity
  • reducing the specific gravity
  • phase homogeneity of the obtained material with respect to its composition.

Keywords:
Metals and alloys, Non-ferrous metals

Use:
Aviation and space technologies, Other technologies related to building industry

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-405033 - 08.08.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 20/13

Title of the invention:
The method of preparation of copper platform for Surface Enhanced Raman Spectroscopy and the copper platform for measurements of surface enhancing Raman effect

Inventors:
Aneta Kowalska, Agnieszka Michota-Kamińska, Witold Adamkiewicz, Marek Tkacz

Field:
Chemistry new materials, Chemical technology, Environmental chemistry

Summary:
The invention provides a process for preparing a copper platform for the measurements of surface-enhanced Raman effect, characterised in that it comprises steps wherein copper hydride (CuH) is subjected to reduction as a result of compressing under elevated pressure, the obtained platform is subjected to purification, preferably using concentrated acetic acid (CH3COOH). The invention covers also a copper platform for the measurements of surface-enhanced Raman effect, being prepared by the above-mentioned process, preferably for the measurements of living cells, wherein the size of copper crystallites is of 30 - 120 nm, and wherein the copper crystallites are distributed uniformly in the bulk and at the surface of the platform.

Advantages / innovative aspects:

  • the preparation process does not require high capital costs,
  • the platforms are relatively easily prepared,
  • and uniform at the whole surface,
  • providing good coefficients of amplification of the Raman signal,
  • the obtained platforms are less bactericidal than the silver ones.

Keywords:
A copper platform, surface-enhanced Raman spectroscopy

Use:
Antibiotics, Clinical research, Bacteriology, Biostatistics and Epidemiology, Cytology, Diagnostics, Pharmacy and Medicines, Physiology, Oncology, Illnesses, Virology, Biochemistry and Biophysics, Cellular and molecular biology, Enzymology and Engineering of protein, Fermentation, Microbiology, Tests in vitro, Toxicology, Gene expression, Micro and Nanotechnologies, Food additives, Quality and safety of food: Research methods, Microbiology of food, Toxicology, Quality control, Measuring devices: Sensors, Other non-destructive techniques, Methods and analytical apparatus, Chemical techniques, Optical techniques.

State of the progress:
stage of prototype, stage of readiness to introduction

Intellectual property rights:
Patent application no. P-404988 – 06.08.2013 - Poland
Patent application no. SE 1450922-8 - 04.08.2014 - Sweden

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 19/13

Title of the invention:
Method for the surface smoothing of polycarbonate

Inventors:
Paweł Dębski, Sławomir Jakieła, Paweł Jankowski, Dominika Ogończyk, Piotr Garstecki

Field:
Chemical technology, industrial Technology, material Technology

Summary:
The patent application teaches how to polish the scratched (not smooth) polycarbonate surface. The method works well while removing scratches from CD's/DVD's, as well while cleaning automobile lamp lenses. It may be successfully applied for smoothing the microfluidics system channels formed in polycarbonate. The proposed method is also applicable for removing clouding from the polycarbonate surface so that to restore the original transparency.

Advantages / innovative aspects:

  • the method rapidly (up to 10 min) removes scratches/clouding from the polycarbonate surface.

Keywords:
polycarbonate, cleaning, rubbing down, scratches, clouding

Use:
Cleaning and preparation of surface, Surface treatment, Ceramic materials, Plastics, Polymers, Properties of materials, Resistance, Corrosion, Organic substances

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent application no. P-404975 - 02.08.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 18/13

Title of the invention:
Method of activation of aluminium fluoride-supported palladium and platinum catalysts, especially for the isomerisation of n-alkanes, light gasoline fractions, light and heavy naphtha fractions and activated in this way catalysts

Inventors:
Ostap Machynskyy, Erhard Kemnitz, Zbigniew Karpiński

Field:
Chemical technology

Summary:
The invention provides a process for activation of palladium and platinum catalysts supported on aluminium fluoride, especially for isomerisation of n-alkanes, low-boiling fraction of gasoline, light and heavy fractions of kerosene, as well as the catalysts activated by the inventive process. In particular, the invention comprises a process for activation of a catalyst, especially for the isomerisation reaction of n-alkanes, based on palladium or platinum nanoparticles supported on active high surface (HS) aluminium fluoride (Pd/HS-AlF3 and Pt/HS-AlF3, respectively).

Advantages / innovative aspects:

  • high rate of conversion of the substrate into products, not less than 40%;
  • high isomerisation selectivity. The concentration of isopentane after the isomerisation reaction of n-pentane reach 90% and more;
  • high working stability of the catalyst. The rate of inactivation of the catalyst under the conditions of n-pentane isomerisation (temperature = 350°C, hydrogen pressure = 1 bar, H2/n-pentane = 12, substrate flow rate = 0.7 ml/min per 200 mg of the catalyst) does not exceed 0.1% per hour.

Keywords:
increasing octane number, isomerisation of n-alkanes, bifunctional catalyst, high surface aluminium fluoride, supported palladium and platinum nanoparticles

Use:
Petrochemistry

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-404974 - 02.08.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 17/13

Title of the invention:
Method of modifying a palladium-gold catalyst, especially for the hydrodechlorination of carbon tetrachloride, and obtained in this way the palladium-gold catalyst characterized by a suitable structure of the active metal phase

Inventors:
Magdalena Bonarowska, Zbigniew Karpiński

Field:
Chemical technology

Summary:
The invention relates to a method of modifying supported catalysts in which the active phase is a Pd-Au alloy, and the presence of unbound with gold palladium results in rapid deactivation of the catalyst during the hydrodechlorination of chlorine-containing organic compounds.
The modification process described in the invention lies in the fact that after a prior reduction in hydrogen of the starting palladium-gold catalyst, palladium unbound with Pd-Au alloy is removed by dilute nitric acid (V). After the acid leaching one can obtain catalysts with higher activity and resistance to poisoning, particularly in the reaction of carbon tetrachloride hydrodechlorination.

Advantages / innovative aspects:

  • Simplifying the preparation of supported palladium-gold catalysts
  • Improving the activity and resistance to poisoning of existing palladium-gold catalysts
  • The method is easy to use without the need of advanced laboratory techniques

Keywords:
Supported Pd-Au catalysts; hydrodechlorination of carbon tetrachloride; Pd-Au alloy homogeneity; catalyst resistance to poisoning

Use:
Chemical technologies, Special Substances, Organic chemistry, Air pollution, Waste management

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-404842, 25.07.2013, Poland
Patent application no. SE 1450912-9,, 23.07.2014, Sweden

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 16/13

Title of the invention:
Method for the synthesis of 1,3,5-triarylbenzene derivatives and truxene

Inventors:
Marek Pietraszkiewicz, Michał R. Maciejczyk, Krzysztof P. Górski

Field:
Chemistry new materials

Summary:
The invention provides a process for manufacturing the derivatives of 1,3,5-triarylbenzene and truxene using aromatic ketones, characterised in that the aromatic ketone is subjected to aldol condensation reaction using an alkyl ester of orthosilicic acid having a general formula Si(Oalkyl)4, wherein alkyl represents the group CnH2n+1, where n = 1 - 10, as well as inorganic or organic non-carboxylic acid as a condensation agent, in an aprotic organic solvent, to yield derivatives of 1,3,5-triarylbenzene, whereas the aromatic group can be phenyl (optionally substituted with R group), pyrenyl, fluoranthenyl, triphenylenyl, and R represents hydrogen, alkyl, chloro, bromo, iodo or nitro group, or to yield derivatives of truxene, unsubstituted or functionalised with alkyl, chloro, bromo, iodo, or nitro group, being the derivatives of 1,3,5-triarylbenzene with a CH2 bridge.

Advantages / innovative aspects:

  • novel synthetic process
  • inexpensive and relatively nonaggressive reagents
  • possibility of carrying out the reaction at room temperature
  • the product often precipitates off the reaction mixture, thus largely reducing the production costs

Keywords:
OLED, optoelectronics, organic photovoltaics, photonics, 1,3,5-triarylbenzene, truxene

Use:
Electronics, Microelectronics:: Technologies of peripheral (mass memory, displays, and others like that), Organic substances, Chemical technology, Special substances, Organic chemistry

State of the progress:
stage of research

Intellectual property rights:
Patent application no. 404606- 09.07.2013 - Poland
Patent application no. GB 1412023.2 - 07.07.2014 - United Kingdom

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 15/13

Title of the invention:
Method of preparation of biosensor containing organized layers of bacteriophages as sensing element and biosensor itself

Inventors:
J. Paczesny, M. Ło¶, Ł. Richter, M. Fiałkowski, R. Hołyst

Field:
Chemistry new materials

Summary:
The present invention relates to a process for the preparation of biosensor for bacteria detection using ordered layers of bacteriophages as a sensory element. The invention comprises the following steps: bacteriophages are applied as a suspension in an aqueous buffer at a conductive plate, said plate carrying the phage suspension is subjected to an electric field, what results in deposition of an ordered layer of phages on a plate, optionally followed by the plate is washed with a buffer solution, preferably of the ionic strength not smaller than the buffer used in step a), most preferably of the same buffer solution.
The invention also includes a biosensor comprising a layer of bacteriophages deposited on conducting plate as a sensory element. Said layer of bacteriophages is in order, which means that more than 45% of the capsids of the phages, preferably more than 80% of the capsids of the phages, and most preferably more than 95% of the capsids of the phage, is facing toward the plate, and a tail available for contact with studied samples.

Advantages / innovative aspects:

  • appropriate ordering of the phage (receptors facing up) causes a significant increase of the sensitivity with the same amount of bacteriophages at the surface
  • preferred arrangement of phage on the sensor surface, reducing the amount of ineffective (in terms of the functionality of the sensor) phages, which receptors are not available for the bacteria in the solution
  • simple, one-step method to improve the sensor quality

Keywords:
bacteriophages, bacteria detection, biosensor, increased sensitivity, ordering, the electric field

Use:
Analitical chemistry, Micro and Nanotechnologies, Bacteriology, Biostatistics and Epidemiology, Diagnostics, Microbiology, Method and Analitycal apparatus

State of the progress:
stage of development

Intellectual property rights:
Patent application no.P-404582 – 08.07.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment

OFFER no. 12/13

Title of the invention:
Method of obtaining a monolayer composed of closely packed nanoparticles coated with hydrophilic and hydrophobic ligands, monolayer and application of this monolayer to cover surfaces

Inventors:
Volodymyr Sashuk, Katarzyna Winkler, Marcin Fiałkowski, Robert Hołyst

Field:
Chemistry new materials

Summary:
The invention relates to a method for the preparation of a densely packed monolayer of nanoparticles and the use of the monolayer to cover solid supports. The method employes gold nanoparticles coated with a mixture of polar (charged) and non-polar ligands in an appropriate ratio. These nanoparticles after deposition onto water surface assemble into sparse monolayer. The addition of organic solvent leads to a compression of the nanoparticle monolayer into a dense film. The resulting film can be transferred onto the surface of solids through the ascent of the substrate from the aqueous solution at an acute angle to the plane of the interface (monolayer).

Advantages / innovative aspects:
Nanoparticle film fabrication is very simple, fast, and can be performed in any lab with no need to apply specialized and cumbersome equipment

Keywords:
nanoparticles, gold, monolayer, ultrathin film

Use:
Micro and Nanotechnologies, Coating, Electrical materials, Composites, Metals and alloys, Inorganic substances, Organic substances

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-404256 – 10.06.2013 -Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 11/13

Title of the invention:
Pd/C catalyst, preparation method of the Pd/C catalyst, its application in the reaction of oxygen electroreduction in the formic acid fuel cell and such fuel cell

Inventors:
Anna Mikołajczuk-Zychora, Andrzej Borodziński, Piotr Kędzierzawski, Leszek Stobiński, Marta Mazurkiewicz, Artur Małolepszy, Agata Kierzek, Karol Juchniewicz

Field:
Chemistry new materials, Environmental chemistry

Summary:
The invention provides a Pd/C catalyst designed for electroreduction of oxygen at the cathode of a formic acid-powered fuel cell. This catalyst contains palladium supported on carbon that has been previously subjected to the optimised preliminary processing (functionalization) with concentrated nitric acid at a temperature of 80°C for 4 - 6 hours. It is characterised by higher specific activity at the cathode of formic acid-powered fuel cell than the more expensive platinum-based catalyst used up to now. The inventive Pd/C catalyst contains palladium, being the metal active in the electroreduction of oxygen, in the form of nanoparticles having a size ranging from 2 nm to 15 nm. The weight concentration of palladium in the catalyst amounts from 10 weight % to 60 weight %. Moreover, the invention comprises the process for obtaining the Pd/C catalyst and its application for reduction of oxygen in the formic acid-powered fuel cell, as well as the formic acid-powered fuel cell using the inventive catalyst.

Advantages / innovative aspects:

  • the obtained Pd/C catalyst demonstrates higher activity in the electroreduction of oxygen in the formic acid-powered fuel cell, compared to the Pt/C catalyst
  • palladium is cheaper compared to platinum, and its abundance in the earth crust is higher

Keywords:
Palladium catalyst, formic acid-powered fuel cell, electroreduction of oxygen, carbon support, functionalization

Use:
Composites, Fuel batteries, Hydrogen production, Unconventional or alternative sources of energy

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-404242 - 07.06.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 10/13

Title of the invention:
New bis(2,2'-bithienyl)methane derivative and the method of its preparation, film of the molecularly imprinted polymer, method of its preparation, and its application for selective detection and determination of nitroaromatic compounds

Inventors:
Tan-Phat Huynh, Marta Sosnowska, Janusz Sobczak, Chandra Bikram K.C., Vladimir N. Nesterov, Francis D'Souza, Włodzimierz Kutner

Field:
Chemistry new materials

Summary:
New electrochemical sensors using molecularly imprinted polymer (MIP) for selective recognition, due to ?-? interactions, and determination of several explosive nitroaromatic compounds (NTs), including 2,4,6-trinitrophenol, 2,4,6-trinitrotoluene, 1,3,5-trinitrobenzene, and 2,4-dinitrotoluene were fabricated. For that a new functional monomer, bis(2,2'-bithienyl)-(4-aminophenyl)methane, was designed and synthesized. The NT recognition signals of the MIP films were transduced to the changes of the film resistance using electrochemical impedance spectroscopy (EIS). The limit of detection (LOD) of these chemosensors was in the range of 8 to 30 nM indicating that they are suitable for practical determination of nitroaromatic explosives at toxic concentration (~10 nM) in natural environment. Moreover, selectivity of the chemosensors with respect to common interferences was in the range of 1.7 to 9.1.

Advantages / innovative aspects:

  • The functional monomer enables selective determination of the NT analytes as well as signal transduction due to conducting properties of the molecularly imprinted polymer prepared with its use.
  • Simple and fast preparation method of recognizing materials directly deposited on surface of the transducer of the chemosensor via electropolymerization.

Keywords:
molecularly imprinted polymer, conducting polymer, polymerization, nitroaromatic explosives, electropolymerization

Use:
Plastics, Polymers, Measuring sensors, Chemical techniques, Analytical chemistry, Biosensors, Toxicology, Soil contamination, Water pollution, Wastewater

State of the progress:
stage of research

Intellectual property rights:
P-404175 - 03.06.2013 - Poland, GB 1409820.6 - 03.06.2014 - United Kingdom

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 8/13

Title of the invention:
[C60]Fullerene derivative and the method of its preparation, molecularly imprinted fullerene polymer film ant the method of its preparation as well as their application for selective detection and determination of adenozine-5'-triphosphate (ATP)

Inventors:
Piyush S. Sharma, Marcin D±browski, Krzysztof Noworyta, Chandra Bikram K.C., Tan-Phat Huynh, Janusz Sobczak, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials

Summary:
[C60]Fullerene derivative and the method of its preparation, molecularly imprinted fullerene polymer film ant the method of its preparation as well as their application for selective detection and determination of adenozine-5'-triphosphate (ATP). Moreover the invention includes using recalled polymer as the element of the recognizing chemical sensor to the selective detection and ATP markings.

Advantages / innovative aspects:

  • High selectivity
  • Chemical resistivity and stability of the polymers.
  • Ease of the thin film preparation.
  • Stability in the positive potential range.
  • High sensitivity.

Keywords:
fullerenes, adenosine-5'-triphosphate, electrochemical polymerization, piezomicrogravimetric chemosensors, capacitive chemosensors, living organizms detection

Use:
Plastics, Polymers, Organic substances, Analytical chemistry, Organic chemistry, Sensor technologies, Medicine: Diagnostics, Quality and safety of food: Microbiology of the food, Quality check, Measuring sensors, Chemical techniques

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-403789 – 07.05.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 7/13

Title of the invention:
A new bis(2,2'-bithienyl)-(4-hydroxyphenyl)methane biotin ester, method of its preparation as well as the containing this ester recognition polymer film and its application for detection and/or determination of oligonucleotides

Inventors:
Marta Sosnowska, Piotr Pięta, Piyush S. Sharma, Chandra Bikram K.C., Bandi Venugopal, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Biosensors
Diagnostics

Summary:
A newly synthesized functional monomer, vis., biotinylated bis(2,2'-bithien-5-yl)methane, was electropolymerized under potentiodynamic conditions. The biotin-containing resultant polymer film irreversibly bound neutravidin. This binding enabled preparation of a label-free biosensor for determination of a (nucleobase sequence)-specific oligonucleotide. Detectability of the devised and fabricated herein piezomicrogravimetric (PM) chemosensor for oligonucleotides was lower than that of the impedimetric chemosensor (EIS) (50 nM and 0.5 pM, respectively) also prepared herein. Advantageously, however, the former operated under the flow-injection analysis conditions and in the absence of an electrolyte, and was capable of reversible binding of the target oligonucleotide. The PM and EIS biosensors were appreciably selective with respect to mismatched target oligonucleotides.

Advantages / innovative aspects:

  • A simple modification method of an electrode surface with biotin is provided. This is achieved by deposition of a conducting polymer, which allows for electrochemical signal transductions.
  • Two examples of biosensors that allow for fast and selective oligonucleotide determination are given.

Keywords:
molecularly imprinted polymer, oligonucleotide, chemosensor, sensor, conducting polymer, electropolymerization, neutravidin, avidin, biotin

Use:
Plastics, Polymers, Analytical chemistry, Clinical research, Diagnostics, Health Service, Measuring sensors, Chemical techniques

State of the progress:
stage of development

Intellectual property rights:
Patent application no. P-403766 - 06.05.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

Attachment:
Graphs

OFFER no. 6/13

Title of the invention:
A device for generation of compound droplets and a method of generation of such droplets

Inventors:
Jan Guzowski, Piotr Garstecki, Sławomir Jakieła

Field:
Chemistry new materials
Chemical technology

Summary:
The invention reports a microfluidic chip for generation of multiple droplets, i.e., droplets built of multiple immiscible liquid segments with different chemical content. Architecture of the chip is compatible with the technique of generation of the droplets "on-demand" which exploits valves to control the volumes of the individual drops. This technique, in combination with the specific architecture of the chip, allows for generation of multiple droplets with prescirebed internal structure including prescribed volumes of the individual segments and their relative spatial configuration. In particular, it allows for generation of the microdroplets potentially useful in controlled release, composed of a segment containing the active compound being surrounded by a shell of tightly packed neutral segments.

Advantages / innovative aspects:

  • The architecture of the chip allows for generation of multiple droplets composed of arbitrary number of segments of 3 different phases
  • Specific geometry of the microfluidic junction prevents coalescence of the segments at the junction
  • In combination with the technique of "on-demand" generation of dropelts the chip allows for controlled formulation of core-shell structures with multiple cores, also those in which a chosen core is placed centrally

Keywords:
microfluidics, multiple droplets, emulsions, surface tension, microcapsule, drug release

Use:
Pharmaceutics, Physics of fluid, Micromechanics, Hydraulics, Micro and Nanotechnology, Pharmacy and Medicines, Food technology

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-403548 – 15.04.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

Attachment

OFFER no. 4/13

Title of the invention:
Method of determining the efficiency of double labeling of double-stranded DNA with a fluorescent dye using fluorescence correlation spectroscopy and its application in biochemical analysis

Inventors:
Sen Hou, Lili Sun, Stefan Wieczorek, Tomasz Kalwarczyk, Tomasz Kamiński, Robert Hołyst

Field:
Analytical chemistry

Summary:
Double-stranded DNA (dsDNA), fabricated by annealing of complementary single-stranded DNA (ssDNA) labeled with the same fluorescent dyes, is of variety of applications for quantitative bioassay. However, imperfect labeling of ssDNA results in coexistence of dsDNA molecules labeled with one or two dyes, which influences the results of quantitative measurement. Unfortunately, the existing methods is insufficient to measure the percentage of the double-labeled dsDNA component in the total fluorescent DNA molecules (DDLE also called DNA double labeling efficiency) and even cannot distinguish the two components. We presented three methods based on fluorescence correlation spectroscopy (FCS) technique to quantitatively measure the DDLE when DNA are labeled with the same dye.

Advantages / innovative aspects:

  • We took into account the influence of triplet states of dyes
  • We developed a self-checking method to estimated the DDLE
  • The result is of good accuracy

Keywords:
fluorescence correlation spectroscopy (FCS), DNA double labeling efficiency fluorescent dye

Use:
Biochemistry and Biophysicist, Method and Analitycal apparatus

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent application no. P-402764 – 14.02.2013 Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Links to the publications
1, 2


OFFER no. 3/13

Title of the invention:
Nucleobase substituted bis(2,2'-bithienyl)methane and its preparation procedure, a molecularly imprinted polymer film and its preparation procedure as well as application of the molecularly imprinted polymer film for determination and release of 5-fluorouracil

Inventors:
Tan-Phat Huynh, Francis D´Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials

Summary:
A 6-aminopurine (adenine) derivative of bis(2,2'-bithien-5-yl)methane, the 4-[2-(6-amino-9H-purin-9-yl)ethoxy]phenyl-4-[bis(2,2'-bithien-5-yl)methane], Ade-BTM, was designed and synthesized to serve as the functional monomer for recognition of 5-fluorouracil (FU), an antitumor drug, by the RNA-type nucleobase pairing driven molecular imprinting. The stability constant of the FU and Ade-BTM (1:2) pre-polymerization complex formed was, K = 2.17(±0.07)×10^7 M^-2. The FU-templated molecularly imprinted polymer (MIP-FU) films were deposited on the ITO or Au film coated glass slides, the Pt disk electrodes, or the 10-MHz quartz crystal resonators by potentiodynamic electropolymerization from solution of FU, Ade-BTM, and the tris(2,2'-bithi-5-yl)methane, TTM, cross-linking monomer at the FU:Ade-BTM:TTM = 1:2:3 mole ratio. The UV-vis and FTIR spectra of the MIP-FU films confirmed the FU template presence in the MIP-FU film, and then its absence after extraction. The stability constant of the complex of the MIP cavity and FU was determined using piezoelectric microgravimetry (PM) under both batch- and flow-injection analysis conditions. For FU determination, the MIP-FU unit was used. This unit was controlled by DPV, CI, or PM with detectability of 56 nM, 75 nM, and 0.26 mM, respectively, which means the former two are suitable for the FU determination in blood plasma or serum (~500 nM). Moreover, the CI is appreciably more sensitive to FU than to its common interferences.

Advantages / innovative aspects:

  • Thin films of our polymer molecularly imprinted (MIP) with 5-fluorouracil, an antitumor drug, serve as recognition units of chemical sensors for determination of this drug.
  • Stable thin films of this MIP material are readily deposited from solution of the complex of 5-fluorouracil and the dedicated functional monomer, by potentiodynamic electropolymerization, onto different conducting substrates.
  • The chemosensors were appreciably selective with respect to common interferences because molecules of 5-fluorouracil interacted much stronger than molecules of the interferences with the molecular cavities imprinted in MIP.

Keywords:
5-fluorouracil, molecularly imprinted polymer, electropolymerization, capacitive impedimetry, piezoelectric microgravimetry

Use:
Clinical, Measuring devices, Chemical techniques, Analytical chemistry

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-402675 – 05.02.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 30/12

Title of the invention:
A method of synthesis of amino – mercapto ligands and their use for the functionalization of metallic nanoparticle surface, in particular gold.

Inventors:
Tomasz Andryszewski, Michalina Iwan, Marzena Wydryszek, Marcin Fiałkowski, Robert Hołyst

Field:
Chemistry new materials

Summary:
The patent application reveals the synthesis procedure of aminothiolalkil ligands, of the general formula HS-CH2-(CH2)n-CH2-NH3+Cl-, where n=1-7, and their utilization in nanoparticle surface functionalization, in particular of gold nanoparticles. The obtained nanoobjects possess the ability to spontaneously migrate and self-assemble at the liquid-liquid interface of water/alcohol/aliphatic hydrocarbon biphasic systems. Moreover, the presence of the highly reactive amino group in the terminal position of the nanoparticles’ surface ligands renders them capable of cross-lining, both in the aqueous phase and at the liquid-liquid interface.

Advantages / innovative aspects:

  • Low cost of materials.
  • Facile separation of final products.
  • The gold nanoparticle functionalization process takes place in aqueous environments and in room temperature.

Keywords:
metallic nanoparticles, surface functionalization, self-assembly at interfaces

Use:
New materials preparation, Inorganic substances, Organic substances, Inorganic chemistry

State of the progress:
research completed

Intellectual property rights:
Patent application no. P-402057 - 14.12.2012 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 28/12

Title of the invention:
Catalyst Ru/Pd/C, method of preparation of the catalyst Ru/Pd/C, its application in direct formic acid fuel cells and such a fuel cell.

Inventors:
Piotr Kędzierzawski, Anna Mikołajczuk, Andrzej Borodziński, Leszek Stobiński

Field:
Chemistry new materials, Environmental chemistry

Summary:
The invention provides a Ru/Pd/C catalyst designed for electrooxidation of formic acid at the anode of a formic acid-powered fuel cell. This catalyst contains palladium and ruthenium supported on carbon, wherein the nominal atomic ratio of ruthenium to palladium ranges from 0.2 to 1.5. Ruthenium occurs in the metallic form in the Ru/Pd/C catalyst, and it does not form an alloy with palladium. The catalyst activates itself by spontaneous oscillations of the cell voltage, without the need for providing energy from the external system. The invention comprises a process for manufacturing the Ru/Pd/C catalyst, its application for electrooxidation of formic acid in the formic acid-powered fuel cells, as well as the formic acid-powered fuel cell using the inventive catalyst.

Advantages / innovative aspects:

  • the obtaining anode Ru/Pd/C catalyst, in contrast to the Pd/C catalyst, provides a long-term operation of the formic acid-powered fuel cell in the solutions of analytically pure formic acid

Keywords:
Palladium catalyst, ruthenium, formic acid-powered fuel cell, electrooxidation of formic acid, nanocomposites

Use:
Composites, Fuel batteries, Hydrogen production, Unconventional or alternative sources of energy

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-401742 - 23.11.2012 – Poland
Patent application no. DE 10 2013 112 288.4 - 08.11.2013 - Germany

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 27/12

Title of the invention:
Method of depositing metal nanoparticles on the surface of semiconductor materials and surface obtained by this process

Inventors:
J. C. Colmenares Quintero, A. Magdziarz

Field:
Analytical chemistry
Chemistry new materials
Chemical technology
Environmental chemistry

Summary:
The present invention is a method of depositing metal nanoparticles, especially mono- and bimetallic nanoparticles on semiconductor materials, using the synergistic effect of ultrasound and ultraviolet radiation. The invention also includes the surface of the semiconductor material covered with metallic nanoparticles, especially mono- or bimetallic ones, obtained by this procedure.

Advantages / innovative aspects:

  • Very short time of different metals’ nanoparticles supported onto semiconductor surface.
  • This method allows the synthesis of hybrid materials with very good metals distribution on the surface of any type of semiconductor.
  • Through this method it is possible to prepare supported alloys with very good degree of metals miscibility.
  • This method takes use of the synergetic effect of two low-rate invasive energy sources (sonication and photons energy).

Keywords:
Catalysts, ultrasounds, light energy, mono- and bimetallic semiconductor films, photoactive materials

Use:
Micro and Nanotechnologies, Electronic nanoengineering, Environment, Semiconductors

State of the progress:
stage of research

Intellectual property rights:
Patent application P-401693 - 20.11.2012 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Graphs

OFFER no. 14/12

Title of the invention:
Antimony electrode for pH measurement

Inventors:
Iwona Flis-Kabulska, Tadeusz Zakroczymski, Janusz Flis

Field:
Instruments: Measurement
Chemistry: Basic materials chemistry, Surface technology, coating

Summary:
The present invention concerns an antimony electrode for pH measurement, especially in the short, well-defined distance from the surface, of about 0.05 to 0.2 mm. The electrode is a glass capillary with antimony core, lent on the examined surface at a desired angle. Distance of the electrode tip from the surface is determined by the diameter and the angle of inclination of the capillary. The electrode is sensitive to small changes in pH due to the occurrence of a confined site between the tip and examined surface; this favors the concentration of reaction products under the tip.

Advantages / innovative aspects: The device according to the invention:

  • is simple in manufacturing,
  • does not contain mercury,
  • can be used in any position (no liquid),
  • its placement on the examined object is simple (it is freely lent),
  • distance from the examined surface is exactly defined and reproducible,
  • has a high sensitivity to changes in pH.

Keywords:
antimony microelectrode, pH, measurement at the surface

Use:
The electrode is designed for laboratory testing, in particular for measurements of pH at the surface of metal electrodes under varying electrochemical conditions.

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Utility model application in Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication:
1

Attachments:
1, 2, 3,

OFFER no. 13/12

Title of the invention:
Portable Vacuum Case with a Sight-Glass

Inventors:
Janusz Sobczak, Aleksander Jabłoński, Włodzimierz Kutner, Krzysztof Noworyta, Andreas Glenz

Field:
Analytical chemistry
Chemistry new materials
Field:
Instruments: Optics, Measurement
Chemistry: Surface technology, coating

Summary:
Presented invention describes portable vacuum case with two sight-glasses. The case is capable of transporting and measuring samples in high vacuum. Such conditions are required, for example, for semiconductors during their processing or characterization. Described vacuum case with dedicated sight-glasses is devised for both easy transport of samples, as well as their spectral characterization in the high vacuum without need to remove and transfer sample to another vacuum system. The case allows for studies of surface and composition of the sample by appropriate optical methods, such as spectroscopy in UV, visible or infrared spectral ranges, or ellipsometry.

Advantages / innovative aspects:

  • Portable vacuum case can be mounted in the spectrophotometer.
  • Portable vacuum case can work in high vacuum.
  • Possibility of the case connection to vacuum chamber and moving samples in and out of the chamber.
  • Two sight-glasses allow for measurements in UV, visual and infrared spectral range.
  • Possibility of spectral measurements in both, transmission and reflection modes.

Keywords:
portable, vacuum, case, Sight-Glass

Use:
Analytical chemistry, Micro. and Nano.technologies, Biochemistry and Biophysics, Methods and analytical apparatus, Optical techniques

State of the progress:
stage of prototype

Intellectual property rights:
Patent applications No P-399921 – 12.07.2012 – Polska,
EP 13174926.9 – 03.07.2013 – Europa

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 12/12

Title of the invention:
The method of coating nanoparticles with a layer of thiol ligands

Inventors:
Volodymyr Sashuk, Marcin Fiałkowski, Robert Hołyst

Field:
Chemistry: Surface technology, coating Field:
Instruments: Optics, Measurement
Chemistry: Surface technology, coating

Summary:
The present invention relates to a novel method of coating the surface of metal and semiconductor nanoparticles by thiol ligands. The method employs xanthates which adsorb in the presence of a weak base onto the surface of the nanoparticles as a thiol ligands.

Advantages / innovative aspects:

  • Xanthates, in contrast to thiols, are easier to synthesize and chemically stable
  • The method allows to modify the surface of nanoparticles with functional groups incompatible with the thiol group.

Keywords:
Surface, nanoparticles, modification, thiol

Use:
Surface modification of nanostructures

State of the progress:
stage of research

Intellectual property rights:
Patent in Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 5/12

Title of the invention:
Thiophene derivatives, molecularly imprinted polymer formed by polymerization of thiophene derivatives and the use thereof for selective determination and controlled release of adenosine-5’-triphosphate (ATP)

Inventors:
Tan-Phat Huynh, Agnieszka Pietrzyk-Le, Chandra Bikram K.C., Krzysztof Noworyta, Janusz Sobczak, Francis D'Souza, Włodzimierz Kutner

Field:
Analytical chemistry
Chemistry new materials
Chemical technology
Environmental chemistry

Summary:
The invention involves to (a) new chemical compounds, derivatives of thiophene, vis., uracilphenyl-4-[bis(2,2’-bithienyl)methane] and 1-methylamide-4-[bis(2,2’-bithienyl)methane]. (b) Moreover, the invention involves a molecularly imprinted polymer prepared by electrochemical polymerization with the use of the above compounds as well as application of this polymer as a recognition unit in the chemosensor for selective determination of adenosine-5'-triphosphate (ATP), or as a material for controlled release of ATP.

Advantages / innovative aspects:

  • The devised and fabricated polymer is easy to prepare in the form of a stable and chemically resistant thin film.
  • It can be deposited on substrates with variety of shapes.
  • It allows for selective and reversible binding of ATP.
  • A chemosensor with a recognition film made of this polymer exhibits high selectivity and high sensitivity with respect to ATP as well as appreciably low detection limit.

Keywords:
adenosine-5’-triphosphate, ATP, chemoczujnik, tiofen, polimery przewodz±ce, capacitive impedimetry, piezoelectric micrograwimetry

Use:
Biosensors, Analytical chemistry, Sensors, Chemosensor for determionation of ATP in biological samples, Material for selective release of ATP, Clinical research, Diagnostics, Biomedical engineering, Biochemistry and Biophysicist, Cell and molecular biology, Genetic engineering, Molecular modelling, Tests In vitro, Food additives, Food processing, Food technology, Food quality control, Chemical techniques

State of the progress:
stage of development

Intellectual property rights:
Patent application No P-398275- 29.02.2012 - Poland
Patent application No GB 1302943.4 – 20.02.2013 - United Kingdom

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 4/12

Title of the invention:
Derivatives of bis(2,2'-bithienyl)methane, molecularly imprinted polymer prepared via polymerization of bis(2,2’-bithienyl)methane derivatives and application of this polymer film for selective quantification and release of adrenaline

Inventors:
Tan-Phat Huynh, Wojciech Lisowski, Włodzimierz Kutner, Chandra Bikram K.C., Francis D'Souza

Field:
Analytical chemistry
Chemistry new materials

Summary:
New chemical sensors for selective determination of adrenaline were fabricated. For that, a thin film of a molecularly imprinted polymer (MIP) was templated with protonated adrenaline. Differential pulse voltammetry (DPV), capacitive impedimetry (CI), or piezoelectric microgravimetry (PM) was integrated within each chemosensor for analytical signal transduction. First, pre-polymerization complex of protonated adrenaline with bis(2,2'-bithienyl)methane substituted with either benzo-(18-crown-6) or 4-carboxyphenyl was formed in solution. Then, an adrenaline-templated MIP film was deposited on the electrodes by potentiodynamic electropolymerization. The lower limits of detection were 2 nM, 0.5 µM, and 1.5 µM for the DPV, PM, and CI chemosensor, respectively, indicating suitability of the DPV chemosensor for adrenaline determination in biological systems (~50 nM). The chemosensors were appreciably selective to adrenaline in the presence of common interferences.

Advantages / innovative aspects:

  • The functional monomers enable selective determination of adrenaline as well as signal transduction due to conducting properties of the molecularly imprinted polymer prepared with their use.
  • Fast and straightforward method of preparation of recognizing materials directly deposited on surface of the transducer of the chemosensor via electropolymerization.

Keywords:
molecularly imprinted polymer, adrenaline, chemica sensor, chemosensor, conducting polymer, electropolymerization

Use:
Plastics, Polymers, Analytical chemistry, Clinical research, Health Service, Measuring sensors, Chemical techniques

State of the progress:
stage of development

Intellectual property rights:
Patent application No P-398219 - 24.02.212 r., Patent PL 217424 - 04.08.2014 r.

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

Patent

Figure

OFFER no. 2/12

Title of the invention:
Method for the on-demand separation of paramagnetic material from droplet and the apparatus for the on-demand separation of paramagnetic material from droplet

Inventors:
Paweł Dębski, Piotr Garstecki, Sławomir Jakieła

Field:
Instruments: Analysis of biological materials
Chemistry: Biotechnology

Summary:
The present invention describes the method of on-demand separation of paramagnetic material from a droplet and a system for an on-demand separation of paramagnetic material from a droplet. The technique is based on the division of droplet into two droplets; one of which containing most of volume of initial droplet, nut no paramagnetic material, and another containing only paramagnetic material. The invention also describes a microfluidic system for such division of droplets.

Advantages / innovative aspects:

  • non-invasive metod of the separation of paramagnetic beads from droplets in a microfluidic system
  • separation on demand – the paramagnetic material is separated from the droplet only if necessary
  • applicable for microfluidic channels with oval and rectangular cross section, which is particularly important for lab-on-chip techniques
  • the system provides the separation of more than 99% of paramagnetic material from droplets
  • the improvement of the efficiency of the separation is due to the change of the shape of the channel, i.e. by widening its short segment

Keywords:
microfluidic techniques, lab-on-chip, diagnostics, paramagnetic beads

Use:
Plastics, Polymers, Analytical chemistry, Clinical research, Health Service, Measuring sensors, Chemical techniques

State of the progress:
stage of research

Intellectual property rights:
Patent in Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment
Stages of separation of the paramagnetic material from a droplet in a microfluidic channel with square cross-section

OFFER no. 40/11

Title of the invention:
Method for depositing metal nanoparticles on the surface and platform to the measurements SERS or LSPR

Inventors:
Marta Siek, Joanna Niedziółka-Jönsson, Marcin Opałło, Agnieszka Kamińska, Anna Kelm, Robert Hołyst

Field:
Chemistry: Surface technology, coating, Micro-structural and nano-technology

Summary:
The subject of this invention is the method of electrodeposition of metal nanoparticles on the surface of the electrode, the surface fabricated this way and its application as a platform for methods using surface plasmon resonance effect (e.g. surface-enhanced Raman spectroscopy, SERS, and localized surface plasmon resonance, LSPR).

Advantages / innovative aspects:

  • possibility to cover large surfaces with nanoparticles
  • possibility to measure SERS and LSPR signals simultaneously
  • high reproducibility and repeatability of LSPR and SERS spectra over the same morphology of the platform
  • potential applications in every method involving surface plasmon resonance effect (e.g. MEF)
  • ease of integration with other elements of the biosensor

Keywords:
electrodeposition, localized surface plasmon resonance, surface-enhanced Raman spectroscopy, biosensors

Use:
Platform for simultaneous examination of localized surface plasmon resonance and surface-enhanced Raman spectroscopy. Can be used as a part of biosensor for e.g. virus detection or in other works involving small amounts of the analyte.

State of the progress:
stage of prototype

Intellectual property rights:
Patent in Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to publication

OFFER no. 24/11

Title of the invention:
System and method for high-throughput formation and merging of droplets produced on demand

Inventors:
Jan Guzowski, Piotr Korczyk, Sławomir Jakieła, Piotr Garstecki

Field:
Chemistry new materials, Chemical technology

Summary:
Microfluidics technology allows to form unusually monodispersive emulsions having strictly controlled droplet volumes. Similarly, it allows also to form multiple droplets containing a set of liquid cores covered with a liquid coating. The techniques to form droplets on demand allow to form emulsions having strictly programmed distribution of sizes of droplets in the emulsion, and a strictly defined distribution of architecture of multiple droplets. For example, it is possible to form emulsions containing double droplets with the core containing the active substance, and a coating of controlled thickness, to control the release of the active substance. It is possible to form an emulsion having a strictly defined distribution of thickness of coatings, what makes it possible to control the time profile of releasing the active substances in the target environment. Besides, the claimed systems make it possible to form a droplet from two or more different liquids, and to combine pairwise the droplets containing different solutions, to mix these solutions, and to carry out the chemical reactions inside the droplets in order to improve the yield and selectivity of the synthesis. This patent application covers parallel systems, that offer very high flow capacity.
The appropriate design of a net of channels makes it possible to divide the flow from one channel into a series of parallel branches, so that the volumetric flow rates are identical in all branches. Due to such a multiplication of flow, it is possible then to generate identical droplets at many parallel junctions simultaneously. The inventors demonstrated experimentally the possibility to achieve in ths way increasing the frequency of droplet generation by two orders of magnitude, but there is no substantial limitation to further increasing this frequency by increasing the number of channels. The necessary condition for uniform distribution of flow over all branches is to adjust appropriately the hydrodynamic resistance of channels. Initially, the flow is directed to a broad and deep tank serving as a pressure reservoir, from which the parallel branches deliver the fluid to junctions generating droplets. An important factor for the stability of droplet formation is the appropriately high hydrodynamic resistance of the outlet branches containing the already generated droplets. This resistance should be sufficiently high to make sure that the presence of droplets in a given branch does not result in significant changes in the resistance of that branch.

Advantages / innovative aspects:

  • The significant advantages of the high flow droplet formation technique using valves, being the subject of this patent application, is the possibility of generating i) monodispersive emulsions irrespectively of fluctuation of the feed pressure, as well as ii) emulsions having an exceptionally large fraction of volume of droplets. Achieving the defined size of droplets, irrespectively of the temporary flow rate of the droplet phase is possible due to use of feedback shutting off the droplet phase flow only when the droplet achieves the defined length in the channel (the detection is performed using a camera). Simultaneously, the use of valves makes it possible to generate arbitrarily large droplets at the fixed volume of the continuous phase. When the fraction of droplet volumes exceeds about 74%, then droplets inside the emulsion undergo self-organisation into a crystalline lattice. The ordered emulsion of this type can be further used for the synthesis of porous materials having a well-defined structure and given pore sizes between them. In the recent years, a rapid progress of the chemical synthesis based on microfluidics systems has been observed. This is caused by a much better control of reaction conditions for the syntheses carried out in flow reactors. The reaction parameters such as a uniform distribution of concentrations of reagents and temperature in the whole volume of the reaction mixture, a precise adjustment of proportions of reagents and catalysts, are of key importance for the yield and selectivity of the reactions. One of the most important problems appearing during the development of novel methods of chemical synthesis is the optimisation of the reaction conditions. It requires a precise adjustment of reagent concentrations, temperature, reaction time, the appropriate solvent. The microfluidics systems are perfect tools for carrying out the optimisation of the reaction conditions. They allow for exceptionally precise adjustment of the composition of reagents (catalysts) by simple control of size of the droplets to be combined. They allow for easy control of reaction time and temperature, and the integration with analytic systems, such as HPLC, UV, IR, makes it possible to fully monitor the yield and selectivity. An unquestionable advantage of such systems is the possibility to carry out the complete optimisation using minimum amount of reagents and solvents, what minimises the amount of wastes.

Keywords:
microfluidics, droplet, surface tension, high throughput, emulsion, automation, monodispersity, multiple droplet, multiple emulsion, microreactor, parallel droplet generators

Use:
Automatic control, Grinding down, Control of processes, Chemicals, Storing materials (solids, gases, liquids), Pharmaceutics, Coating, Mechanical engineering, Hydraulics, Micro and Nanotechnology, Pharmacy and Medicines, Biomedical engineering.
High flow capacity droplet systems can also find use in combinatorial syntheses leading to formation of product libraries, that can be directly subjected to the activity assays in the further part of the microfluidics system. The claimed invention can find the following industrial applications. 1. High flow capacity formation of simple emulsions having strictly defined distributions of droplet sizes. Applications in food industry and cosmetic industry.
2. High flow capacity formation of complex emulsions having strictly defined distributions of sizes of cores and coatings. Applications in cosmetic industry and in pharmaceutical industry.
3. Installations for carrying out specialty chemical syntheses in a strictly controlled and safe way, allowing for easily scalable production.

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-395775 – 27.07.2011 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Links to the publication:
1, 2

OFFER no. 21/11

Title of the invention:
Method for deposition of nanoparticles on solid substrates and surface covered by this method

Inventors:
Jan Paczesny, Krzysztof Sozański, Robert Hołyst, Igor Dzięcielewski, Andrzej Żywociński, Witold Adamkiewicz

Field:
Chemistry new materials

Summary:
The invention comprises a method for controlled deposition of a monolayer of nanoparticles (NPs) on a solid surface, featuring the Langmuir-Blodgett technique. A mixture of NPs and a liquid crystaline (LC) compound forms a 2D network when spread on water surface and can be subsequently transferred onto a solid substrate. Adjustment of the compression of the formed film allows for facile control over the mean size of the mesh domains. A desired degree of coveridge of the surface with the NPs can be achieved by tuning the composition of the utilized NP/LC mixture. If gold NPs are used, the obtained structure can be used in the Chemical Vapor Deposition procedure to grow GaN nanorods only in places where the NPs were deposited.

Advantages / innovative aspects:

  • single-layer coverage of a solid substrate with nanoparticles
  • particular morphology of the coverage: 2D network of NPs
  • control over the extent of surface coverage as well as mean size of the network domains
  • no particular requirements regarding the covered surface
  • different kinds of NPs can be applied (constitution, coating, size)
  • easily scaling-up for effective coverage of large areas (method based on self-assembly)

Keywords:
nanoparticles, self-assembly, 2-dimensional networks, coating

Use:
Controlled manufacturing of 2D, network-like structures of naniparticles, potentially applicable to production of SERS substrates, nanotips, catalysts, biosensors, electronic components. Electronic nanoengineering, Analytical chemistry, Inorganic chemistry, Biosensors, Mikro. and Nano.technologies

State of the progress:
stage of development

Intellectual property rights:
Patent P-395009, 19.09.2014 - Poland
Co-owner Institute of High Pressure Physics of the Polish Academy of Sciences

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Links to the publication:
1, 2

OFFER no. 20/11

Title of the invention:
Porphyrine derivative, polymerized film containing derivative of the porphyrin and its application for determination and release of the nicotine

Inventors:
Krzysztof Noworyta, Włodzimierz Kutner, Channa A. Wijesinghe, Francis D’Souza

Field:
Analytical chemistry
Chemistry new materials
Sensors
Quality control

Summary:
The invenntion encompaseses two chemical compound 5-(2-phenoxyacetamide)-10,15,20-tris(triphenylamino)porphyrinato zinc(II) and 5-(2,5-phenylenebis(oxy)diacetamide)-10,15,20-tris(triphenylamino)porphyrinato zinc(II). It encompasses also polymerized film of the compounds as recognition element of chemosensor for determination of nicotine, myosmine and cotinine. It includes also application of the film as material for controlled release of nicotine

Advantages / innovative aspects:

  • High selectivity and sensitivity
  • Ease of preparation in the form of both thin films and powder
  • High chemical resistivity and high stability.

Keywords:
Porphyrin, nicotine, myosmine, cotinine, alkaloidy, elektropolimeryzacja, piezomikrograwimetria, chemoczujnik, uwalnianie nikotyny

Use:
Chemosensor for determionation of selected alcaloids (mainly nicotine) or substance for selective release of nicotine (element of transdermal patches, or chewing gums)

State of the progress:
stage of development

Intellectual property rights:
PL 217425 – 18.12.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Patent PL217425B1

OFFER no. 18'/11

Title of the invention:
Device for measurement of the rate of hydrogen entry into metals

Inventors:
Iwona Flis-Kabulska, Janusz Flis, Tadeusz Zakroczymski

Field:
Instruments: Measurement, Surface technology, coating

Summary:
TThe present utility model concerns a set for measurement of the rate of hydrogen entry into metals under various conditions, including elevated temperatures and aggressive media. The set is designed for laboratory examinations. The set enables a fast and easy insertion of the sample into the examined solution when the latter is under stabilised conditions (temperature, deaerated or saturated with gas), including highly aggressive solutions and elevated temperatures. This enables a change of samples without dismounting the entire apparatus.

Advantages / innovative aspects:
The device allows to:
- quick introduction of the sample into the tested solution,
- easy replacement of the sample without removing the entire measuring set,
- measurements on the same sample after a desired surface treatment,
- making measurements not only in any electrochemical vessel, but also in industrial installations.

Keywords:
set for measurements of hydrogen entry, Devanathan-Stachurski method

Use:
The set with the probe enables measurements of hydrogen entry into metal membranes in laboratory examinations.

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Protection right in Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment:
Figure

Link to the publication

OFFER no. 18/11

Title of the invention:
Probe for measurement of the rate of hydrogen entry into metals

Inventors:
Iwona Flis-Kabulska, Janusz Flis, Tadeusz Zakroczymski

Field:
Instruments: Measurement, Surface technology, coating

Summary:
The present utility model concerns a probe for measurement of the rate of hydrogen entry into metals under various conditions, including elevated temperatures and aggressive media. The probe with an examined sample can be used in laboratory examinations and in industrial installations. The essence of present solution involves a modification of the measuring set of the Devanathan-Stachurski method, enabling a fast insertion of the probe with a sample into a tested medium and immediate start of the measurements.

Advantages / innovative aspects:
The device allows to:
- quick introduction of the sample into the tested solution,
- easy replacement of the sample without removing the entire measuring set,
- measurements on the same sample after a desired surface treatment,
- making measurements not only in any electrochemical vessel, but also in industrial installations.

Keywords:
hydrogen probe, Devanathan-Stachurski method

Use:
The probe is designed for measurement of hydrogen entry into metal membranes in laboratory examinations and in industrial installations.

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Protection right in Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachment:
Figure

Link to the publication

OFFER no. 4/11

Title of the invention:
Nanoparticles coated with hydrophilic ligands, layer thereof and the surface coated therewith

Inventors:
Volodymyr Sashuk, Marcin Fiałkowski, Robert Hołyst

Field:
Chemistry new materials
Chemistry new materials
Sensors
Quality control

Summary:
The invention relates to method for the preparation of nanoparticle monolayer and to the use of the monolayer for surface coating of various materials. Monolayer of nanoparticles is obtained using the Langmuir-Blodgett method. Gold or silver nanoparticles, coated with a mixture of polar (charged) and nonpolar ligands, are placed first on the water surface. Due to the charge, nanoparticles evenly distribute over the water surface, forming a film of a thickness of a single nanoparticle. The nanoparticles, loosely arranged on the surface, then are compressed by means of two movable barriers to yield a dense packed monolayer of nanoparticles. Transferring of the resulting monolayer on surfaces of materials is carried out by vertically, relative to the monolayer, dipping, or the ascent of the substrate.

Advantages / innovative aspects:

  • Obtaining a densely packed monolayer of nanoparticles with a fixed electric charge;
  • Ability to control the density of nanoparticles in the monolayer;
  • A small number of defects (polylayers) in the monolayer produced;
  • The possibility of coating by nanoparticle monolayer both hydrophilic and hydrophobic surfaces.

Keywords:
Nanoparticles, monolayer, charge, Langmuir-Blodgett technique

Use:
Mikro and Nanotechnologies, Coverage, Electric materials

State of the progress:
stage of research

Intellectual property rights:
P-393843 – 03.02.2011 - Poland
Co-owner Warsaw University of Technology

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to the publication

OFFER no. 3/11

Title of the invention:
The method of the synthesis of ZnO nanoparticles

Inventors:
Janusz Lewiński, Kamil Sokołowski, Michał Leszczyński, Karolina Zelga

Field:
Chemistry new materials
Chemistry new materials
Sensors
Quality control

Summary:
The IPR covered by national patent application (P-402624). This invention relates to a method for the preparation of nanostructured ZnO materials for applications in biomedicine and photovoltaics. Where the foreground is capable of industrial or commercial application the owner will adopt measures for its adequate and effective protection. Therefore, any promising results for new products and/or new methods of synthesis elaborated during the project will be the subject of further patent applications.

Advantages / innovative aspects:

  • Control over the size and shape of nanoparticles
  • Biocompatibility and biodegradibility
  • Stability of physicochemical properties
  • Simplicity of functionalization
  • Purity of the material

Keywords:
PZnO, nanoparticles, luminescence, bioimaging, photovoltaics

Use:
Semiconductors, Fuel batteries, Hydrogen production, Solar power (photovoltaic cells), Inorganic chemistry, Mikro. and Nano.technologies, Bacteriology, Diagnostics, Pharmacy and Medicines, Cell and molecular biology, Microbiology

State of the progress:
stage of development

Intellectual property rights:
PL 217969 – 26.02.2014 - Poland
Co-owner Warsaw University of Technology

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Patent PL217969B1

OFFER no. 24/10

Title of the invention:
Mulilayers electrodes for dopamine detection and its application

Inventors:
Anna Celebańska, Marcin Opałło, Adam Leśniewski, Dorota Tomaszewska

Field:
Analytical chemistry
Chemistry new materials

Summary:
The object of the invetnion is the multilayered elcetrode and its application for dopamine detection in the presence of interfering sunstances. The electrode was prepared by "layer-by-layer" method by subsequent immersions of electrode substrate into suspension of positively charged silicate submicroparticles, and negatively charged carbon nanoparticles. The layers formed due to electrostatic attractions of nanoobjects functionalities. This electrode exhibits good electrocatalytic properties toward dopamine oxidation. Its determination with low setection limit is possible even in the presence of ascorbic acid, uric acid, acetaminophen, citric acid, NADH, tryptophan.

Advantages / innovative aspects:

  1. New, multilayered, mechanically stable electrode,
  2. Layer-by-layer technique allows to control electrochemical parameteres of deposited mterial,
  3. Easy and fast way of electrode preparation,
  4. Possible of different shape surface covering
  5. Cheap techniques and material,
  6. The electrode exhibits excellent electrocatalytic behavior towards dopamine oxidation,
  7. Dopamine detection with low detection limit in the presence of intereferences is possible.

Keywords:
dopamine sensor, miltilayered electrode, carnon nanoparticles, silicate particles, layer-by-layer method

Use:
Analitical chemistry, Inorganic chemistry, Measuring sensors, Chemical techniques

State of the progress:
stage of research

Intellectual property rights:
Patent PL 216936, 15.10.2013 - Poland
patent Application DE 10 2011 056 381.4, 14.12.2011, Germany

Expected cooperation:
cooperation agreement, invention development

Link to patent

OFFER no. 18/10

Title of the invention:
Pheromone trap

Inventors:
Jan Zasłona

Field:
Environmental chemistry

Summary:
Use of pheromone traps is one of the methods for controlling pest insects in forests. The pheromone traps function as prognostic and controlling devices, since the foresters can determine the term of swarming of the pests and the danger of damage to the forest, based on the number of caught individuals. To calculate the number of caught insects, approximate methods have been used, that consist in estimating the number of insects based on the volume/weight of the caught insects and the assumed volume/weight of a statistical insect. This project aims at constructing the system for automatic counting the caught insects. The pheromone trap is a device that can be used to control the number of pest insect in the protection of forests due to used smell attractants of sexual or feeding nature. Usually, such a trap is a special box or tube, wherein the attractant for pest insects is placed. The attractants are sensed by insects from various distances, depending on the species, from several hundreds of metres to several kilometres. The attracted insects get inside the trap and fall into a special container, from which they are systematically taken out and destroyed or poisoned on the spot. The attractants are extremely selective and act only for a given species of a pest.

Advantages / innovative aspects:

  1. simple detection system with no optics
  2. the detection area covers all possible profile of insect flow and the number of insects can be determined exactly
  3. the detection of insect flow uses the shadow of an insect
  4. the use of a counting system does not influence the trap operation, and the detector is at the entry of the container for caught insects

Keywords:
Pheromone trap, ecology

Use:
Forest ecology - forest conservation; monitoring the degree of danger from the pest insects.

State of the progress:
stage of prototype

Intellectual property rights:
Protection right PL 67457 for the utility model - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Attachments
Picture
Diploma

OFFER no. 8/10

Title of the invention:
Method for modification of carbon nanotubes, especially polyhedral

Inventors:
L. Stobiński, P. Tomasik, K. Khachatryan, G. Khachatryan, O. Michalski

Field:
Chemistry new materials, Chemical technology

Summary:
The invention presents a method of modification of carbon nanotubes, particularly multiwalled nanotubes. The essence of this method involves the preliminary oxidation of the nanotubes through the incadescing solid nanotubes in the air inside a vessel of adjustable volume and maintaining temperature in the range of 500-700 ° C. Heating is pereformed for 2 to 15 min inside a microwave owen of frequency from 50 MHz to 200 GHz and a power of 100 W to 2000 W. Then the incandescent carbon nanotubes are additionally oxidized by introducing them into either a cooling or cooling-oxidizing liquid medium followed by placing the suspension for about 10 minutes in an ultrasonic bath. The thoroughly disperssed suspension of the oxidized carbon nanotubes is filtered or centrifuged, washed then dried until the fine powder of the final product results.

Advantages / innovative aspects:

  1. purified hydrophilic carbon nanotubes, modified by oxygen groups (-COOH, >CO, -OH),
  2. a high degree of carbon nanotubes dispersion in aqueous medium

Keywords:
carbon nanotubes, purification, modification, oxidation, microwave field, ultrasonic bath, dispersion

Use:
Modified carbon naotubes can be suitable as materials for micro and nanoelectronics, nanodevices, markers, sensors and a variety of composite materials.

State of the progress:
stage of readiness to introduction

Intellectual property rights:
Patent PL 216601 - 06.09.2013 - Poland
Co-owner Warsaw University of Technology

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

Link to patent

Inventions for cooperation and further development

OFFER no. 28/13

Title of the invention:
Microsensor for determination of concentration of hydrogen dissolved in aqueous solutions and a way of hydrogen concentration determination in aqueous solutions

Inventors:
Justyna Jędraszko, Wojciech Adamiak, Wojciech Nogala, Marcin Opałło

Field:
Analytical chemistry

Summary:
The object of this invention is a micro-sensor for determination of hydrogen concentration in aqueous solutions. It consist of passive, potentiometric reversible hydrogen electrode. The maximal size of the sensor is smaller than 250 µm. Another object of invention is a way for determination of hydrogen concentration in aqueous solutions, especially at the interface between two immiscible liquids. The sensor is applicable as a probe in scanning electrochemical microscopy (SECM), what allows the measurement of hydrogen flux generated at soft interfaces.

Advantages / innovative aspects:

  • Non-invasive measurements – the microsensor does not cause local concentration drop of the analyte
  • Low detection limit (10-14 mol dm-3)
  • Broad range of measured concentration of hydrogen (10^-14 ÷ 7,8×10^-4 mol dm^-3)
  • Measurement of flux of hydrogen generated ta soft interfaces

Keywords:
hydrogen potentiometric sensor, liquid-liquid, scanning electrochemical microscopy (SECM), hydrogen reversible electrode (HER)

Use:
Control of processes, Chemicals, Storing materials (solids, gases, liquids), Properties of materials, Resistance, Corrosion, Chemical engineering, Producing apparatus, Chemical technologies, Transfer and hydrogen storage, Fuel batteries, Hydrogen production, Meteorology and Climatology, Micro and Nanotechnologies, Measuring sensors, Method and Analitycal apparatus, Chemical techniques, Dangerous goods

State of the progress:
stage of research

Intellectual property rights:
Patent application no. P-405395 & P-408683 - 19.09.2013 - Poland

Expected cooperation:
contract of sale, licence agreement, cooperation agreement

OFFER no. 32/12

Title of the invention:
Method of uniform coating of electrochemically roughened silver surface with highly developed gold layer and the platform for measuring the surface enhanced Raman effect, particularly of bacteria

Inventors:
E. Witkowska, S. Arumugam, A. Michota-Kamińska, W. Adamkiewicz, J. Waluk

Field:
Chemistry new materials

Summary:
The present invention relates to the method associated with uniform coating of the surface of an electrochemically roughened silver surface with a highly developed gold layer and the platform for measuring the surface enhanced Raman effect, particularly of bacteria. More specifically, the present invention discloses a new platform for the analysis of surface enhanced Raman spectroscopy (SERS) consisting of an electrochemically roughened silver surface covered with highly developed gold layer.

Advantages / innovative aspects:

  • High Raman enhancement factor
  • Small amount of defects on the surface
  • Highly developed surface
  • Wide range of applications in microbiology

Keywords:
Raman, SERS, surface-enhanced Raman spectroscopy, identification of bacteria, detection of bacteria

Use:
Industrial technologies

State of the progress:
stage of prototype

Expected cooperation:
cooperation agreement, invention development

OFFER no. 7/11

Title of the invention:
Composite material, particularly for the construction of electrochemical capacitors, and an electrochemical capacitor

Inventors:
Piotr Pięta, Ievgen Obraztsov, Janusz Sobczak, Włodzimierz Kutner, Krzysztof Winkler, Alan Balch, Sushanta Das, Francis D'Souza

Field:
Analytical chemistry
Chemistry new materials
Sensors
Quality control

Summary:
The invention includes a composite material, especially for the construction of electrochemical capacitors, consisting of carbon nanotubes, CNTs, noncovalently surface modified by 1-pirenbutiric acid (pyr-CNTs) and the polymer obtained from 2'-ferrocenylfulleropyrrolidine (C60Fc) and palladium acetate [Pd(AC)2]. The invention also includes an electrochemical capacitor, wherein at least one electrode is covered with the composite material.

Advantages / innovative aspects:

  • The pyr-SWCNTs|C60Fc-Pd film is electrochemically active in both positive and negative potential range.
  • The pyr-SWCNTs|C60Fc-Pd film features high specific capacitance.

Keywords:
carbon nanotubes, conducting polymer, composite, supercapacitor

Use:
Composites, Energy storage, Batteries and Accumulators

State of the progress:
stage of research

Expected cooperation:
Cooperation agreement, invention development

Link to the publication

Attachments:
Structural formula

OFFER no. 19/10

Title of the invention:
Method of modification of the surface of polycarbonate and the surface of polycarbonate modified with the use of the same method

Inventors:
Wojciech Nogala, Ewa RoĽniecka, Marcin Opałło

Field:
Chemistry new materials
Chemical technology

Summary:
The subject matter of the invention is a zinc-oxygen cell, comprising a zinc anode, an electrolyte and an enzyme-modified biocathode, characterised in that the said biocathode is a ceramic carbon electrode, CCE, modified with laccase and a redox probe. The invention comprises also the application of such cell as an implantable power source.

Advantages / innovative aspects:

  • Biocathode modified with laccase and redox probe
  • Electrolyte: phosphate buffer with chlorides
  • Open circuit voltage above 1.2 V
  • Possibly implantable power source
  • Membraneless cell

Keywords:
Implantable power source

Use:
Storing the electricity, Batteries and accumulators, Fuel batteries, Hydrogen production, Unconventional or alternative energy sources, Clinical research, Surgery, Diagnostics, Biomedical engineering, Neurology, Measuring sensors

State of the progress:
stage of prototype

Expected cooperation:
cooperation agreement, invention development

OFFER no. 17/10

Title of the invention:
Method of modification of the surface of polycarbonate and the surface of polycarbonate modified with the use of the same method

Inventors:
Paweł Jankowski, Ladislav Derzsi, Piotr Garstecki

Field:
Analytical chemistry
Chemistry new materials

Summary:
The present invention relates a method for modifying the polycarbonate surface by treating the surface with appropriate solutions, the result is a highly hydrophilic surface of the polycarbonate. The method according to the invention is characterized by simplicity, high repeatability and long term durability. The modification according to the invention is based on the reaction of carbonate groups of polycarbonate with amino groups of poly(allylamine) (PAH). By forming the urethane bonds polyelectrolyte is strongly linked to the polymeric substrate. Immersion of the PC-PAH surface in a solution of poly(styrene-sulfonate) (PSS) creates a polyelectrolyte bilayer via ionic bonding between the PAH and PSS. The result is a strongly hydrophilic surface properties. The developed method uses a simple apparatus, widely available and inexpensive reagents and is an exceptionally attractive tool for the preparation of microfluidic systems (µFLDs) with a stable, hydrophilic surfaces of microchannels.

Advantages / innovative aspects:

  • use of simple equipment, commonly available and cheap reagents
  • uniquely attractive tool to fabricate microfluidic devices (µFLDs) with durable, hydrophilic surfaces of microchannels
  • this coating allows for stable generation of oil-in-water emulsions of hydrocarbon, silicone and fluorinated oils without the use of surfactants and over days of continuous use.

Keywords:
polycarbonate, microfluidic systems, surface modification, hydrophilic surfaces

Use:
fabrication of microfluidic systems, Plastics, Polymers, Properties of materials, Resistance, Corrosion,Micro- and Nano-technologies

State of the progress:
stage of readiness to introduction

Expected cooperation:
cooperation agreement, invention development

OFFER no. 14/10

Title of the invention:
Method for modification of micro-channel surfaces performed in the polycarbonate object and polycarbonate object containing a microchannel modified with this method

Inventors:
Piotr Garstecki, Paweł Jankowski, Dominika Ogończyk

Field:
Analytical chemistry
Chemistry new materials

Summary:
The subject matter of the invention is a method for modifying surface of microchannels fabricated in a polycarbonate (PC) object. The method represents a unique attractive tool to produce durable and resistant hydrophobic surfaces of microchannels fabricated from polycarbonate.
The method according to the invention is characterised by simplicity, high reproducibility and exceptionally high durability. The modification according to the invention is based on a reaction of carbonate groups of the polycarbonate with amine groups resulting in formation of covalent bonds (urethane bonds). The reaction is simple and easy to carry out. As a result of urethane bond formation, PC surface undergoes a modification rendering it strong hydrophobic properties due to alkyl chains provided by the amine.

Advantages / innovative aspects:

  • use of simple equipment, commonly available and cheap reagents
  • uniquely attractive tool to fabricate microfluidic devices (µFLDs) with durable, hydrophobic surfaces of microchannels
  • allows for carrying out experiments involving highly viscous charged substances (e.g., polyanions such as polysaccharides).

Keywords:
polycarbonate, microfluidic systems, surface modification, hydrophobic surfaces

Use:
fabrication of microfluidic systems, Plastics, Polymers, Properties of materials, Resistance, Corrosion,Micro- and Nano-technologies

State of the progress:
stage of readiness to introduction

Expected cooperation:
cooperation agreement, invention development

OFFER no. 10/09

Title of the invention:
Method for bonding polycarbonate panels preserving their surface micro-structure

Inventors:
Dominika Ogończyk, Judyta Węgrzyn, Paweł Jankowski, Piotr Garstecki

Field:
Analytical chemistry

Summary:
The present invention relates a method of bonding the microchips made of polycarbonate (PC). The presented method uses the phenomenon of swelling the polymer surface layer, which is the result of contact of PC with solvent vapor. The next step is compression of modified elements at a temperature below the glass transition temperature (Tg). The method is characterized by simplicity, high reproducibility and that does not change the surface chemistry and geometry of the microchannels.

Advantages / innovative aspects:

  • preservation of the geometry of the microchannels,
  • low costs,
  • does not affect the physico-chemical properties of the surface

Keywords:
polycarbonate, microfluidic systems, bonding

Use:
Fabrication of microfluidic systems, Join (Soldering, Welding, Studding, Hacking off, Gluing), Plastics, Polymers, Micro- and Nano-technologies

State of the progress:
stage of readiness to introduction

Expected cooperation:
cooperation agreement, invention development

OFFER no. 9/09

Title of the invention:
Microvalve and a a system for microfluidic generation of droplets of liquid and bubbles of gas on demand with prescribed volume and at the prescribed moment.

Inventors:
Krzysztof Churski, Jacek Michalski, Piotr Garstecki

Field:
Chemical technology

Summary:
The invention describes a microvalve and a microfluidic system for generation of droplets on demand with arbitrarily prescribed volume and at arbitrarily prescribed instance. The system useas a pneumatically actuated membrane microvalve integrated with the mcirofluidic system. The system i) allows for precise and reproducible control of the volume of droplets and of the frequency of their generation, ii) can be used to generated droplets from small volumes of samples, and iii) can be used with microfluidic chips fabricated in a range of stiff materials, including polymers, glass, silicon or ceramics.

Advantages / innovative aspects:
The system i) allows for precise and reproducible control of the volume of droplets and of the frequency of their generation, ii) can be used to generated droplets from small volumes of samples, and iii) can be used with microfluidic chips fabricated in a range of stiff materials, including polymers, glass, silicon or ceramics.

Keywords:
droplet, bubble, volume, dosing, microfluidics

Use:
Automatic control, Control of processes, Chemical engineering, Producing apparatus, Chemical technologies, Analytical chemistry, Inorganic chemistry, Organic chemistry, Physics of fluid, Micromechanics, Hydraulics, Micro and Nanotechnology

State of the progress:
stage of development

Expected cooperation:
cooperation agreement, invention development

Attachment

OFFER no. 5/09

Title of the invention:
Molecularly imprinted polymer, method of its preparation, and piezoelectric chemical sensor for detection and determination of biologically active substances selected from a group of biogenic amines, advantageously melamine

Inventors:
Agnieszka Pietrzyk, Włodzimierz Kutner, Raghu Chitta, Francis D'Souza, Francesco Sanicolo, Patrizia R. Mussini

Field:
Analytical chemistry
Chemistry new materials

Summary:
Combination of the melamine templated MIP recognition film and the piezoelectric transducer of the bulk-acoustic-wave resonator results in an exceptionally sensitive and selective melamine piezomicrogravimetric chemosensor of appreciable detectability. The chemosensor was significantly more selective to melamine than to structurally similar interfering compounds, such as cyromazine, cyanuric acid, and ammeline. The determined stability constants of complexes of MIPs with melamine, cyanuric acid, or ammeline, suggest that the imprinted cavities fit the size and shape of the melamine molecule used for imprinting.

Advantages / innovative aspects:

Keywords:
melamine, piezomicrogravimetric chemosensor, quartz crystal microbalance, molecularly imprinted polymer (MIP), flow-injection analysis (FIA), ionic liquid, cyanuric acid, cyromazine, ammeline

Use:
Analytical chemistry, Biosensors, Clinical research, Cellular and molecular biology, Toxicology, Measurements of pollution

State of the progress:
stage of development

Expected cooperation:
cooperation agreement, invention development

Links to the publication:
- 1

OFFER no. 4/09

Title of the invention:
The method of incorporation of carbon nanotubes into ordered surfactant matrix

Inventors:
Stefan Wieczorek, Robert Hołyst, Xia Xin, Hongguang Li

Field:
Chemistry new materials

Summary:
The subject of this invention is the new method of single walled carbon nanotubes (SWNTs) incorporation into lyotropic liguid crystal (LLC) phase formed spontaneously by surfactant (C12E6, SDS, CTAB) during phase separation in the presence of a hydrophilic polymer (PEG, PSS, PDADMAC). The type of lyotropic liquid phase (hexagonal or lamellar) is controlled by varying the ratio of polymer to surfactant. The ordering of surfactant in dilute aqueous solutions induced by hydrophilic polymer was described in “Ordering in surfactant mixtures induced by polymers (J. Phys. Chem. B 2005, 109, 4881).

Advantages / innovative aspects:

  • SWNTs is incorporated into LLC matrix at room temperature.
  • This method is performed at low viscosity micellar solutions.
  • Higher concentration of SWNTs in orderd surfactant matrix can be obtain.

Keywords:
lyotropic liquid crystal (C12E6, SDS, CTAB), polymer (PEG, PSS, PDADMAC), single walled carbon nanotubes

Use:
Composites, Thermodynamics, Mikro. and Nano.technologies

State of the progress:
stage of readiness to introduction

Expected cooperation:
cooperation agreement, invention development

Links to the publications:
- 1,2

OFFER no. 3/09

Title of the invention:
Method of precipitation putting in order the cationic solutions of surface active agents in polar solvents, preferably in water

Inventors:
Robert Hołyst, Marcin Fiałkowski, Ewelina Kalwarczyk, Monika Pyzalska, Joanna Kęska, Monika Gołoś, Karolina Urbaniak

Field:
Chemistry new materials
Chemical technology

Summary:
The present invention relates to a method of phase separation and organization of the solutions of cationic surface active agents (surfactants) in polar solvents, especially in water. In this method, the applied precipitating agent consists of nonionic polymer and inorganic salt. In general, cationic surfactants mix well with nonionic polymers, and such a mixture does not undergo phase separation. It is noted, that for a fixed surfactant concentration, the addition of inorganic salt induces the phase separation even for very low polymer concentrations.
The use of the method according to the invention results that the surface active agentant does not precipitate entirely out of solution, but forms a separate, nontransparent phase with a high content of surfactant. Surfactanr-rich phase is an ordered phase and it coexists with a clear aqueous solution that is enriched in polymer.

Advantages / innovative aspects:
The invention provides a simple and inexpensive manner (inorganic salt is generally much less expensive than the polymer) of affecting the precipitation and organization of solutions of cationic surfactants, particularly in water.
The process is fast - it takes from a few up to tens of minutes.

Keywords:
cationic surfactants, nonionic polymers, inorganic salt, phase separation, ordering

Use:
Separation, Chemicals, Detergents, Water pollution, Wastewater

State of the progress:
stage of research

Expected cooperation:
cooperation agreement – invention



OFFER no. 1/09

Title of the invention:
Method of precipitating and arranging ionic solutions of the surface-active agents, preferably in the mixtures of water and polar solvents

Inventors:
Robert Hołyst, Marcin Fiałkowski, Ewelina Kalwarczyk, Monika Pyzalska, Joanna Kęska, Monika Gołoś, Karolina Urbaniak

Field:
Chemistry new materials
Chemical technology

Summary:
The present invention relates to a method of phase separation and organization the solutions of ionic surface active agents (surfactants) in mixtures of water and of polar solvents. In this method, the precipitating agent is a polyelectrolyte. Preferably, the charge of the polyelectrolyte has the same sign as that of surfactant. The polar solvent may include both protic compounds having so called acidic hydrogens (e.g.,. ethanol), as well as aprotic solvents that do not have acidic hydrogen atoms (eg. acetone).
The use of the method according to the invention results that the surfactant does not precipitate entirely out of solution, but forms a separate phase with a high content of surfactant coexisting with a clear, aqueous solution of polyelectrolyte.

Advantages / innovative aspects:
The method of the phase separation is simple and inexpensive.
The process is fast - it takes from a few up to tens of minutes.

Keywords:
ionic surfactants, polyelectrolytes, phase separation, ordering

Use:
Separation, Chemicals, Detergents, Water pollution,Wastewater

State of the progress:
stage of research

Expected cooperation:
cooperation agreement – invention



OFFER no. 4/08

Title of the invention:
A composite material for the construction of electrochemical capacitors and method of its preparation

Inventors:
Piotr Pięta, Emilia Grodzka, Krzysztof Winkler, Alan L. Balch, Ganesh M. Venukadasulad, Francis D'Souza, Włodzimierz Kutner

Field:
Chemistry new materials

Summary:
A composite material for the construction of electrochemical capacitors consists of a mixture of two conductive polymers, ie. fullerene-palladium (C60-Pd) and bithiophene polymer (PBT), electrochemically deposited on the carbon nanotubes (CNTs), preferably single-wall carbon nanotubes noncovalently surface modified with 1-pyrenebutyric acid (pyr-SWCNTs). The composite was prepared into two steps. In the first step pyr-SWCNTs were deposited on an electrode surface, preferably electrophoretically. In the second step, the film of pyr-SWCNTs was electrochemically coated, preferably under multiscan cyclic voltammetry (CV) conditions, with a mixed film of the fullerene-palladium (C60-Pd) polymer and the polybithiophene (PBT) polymer.

Advantages / innovative aspects:
The pyr-SWCNTs|(C60-Pd)-PBT film is electrochemically active in both positive and negative potential range.
The pyr-SWCNTs|(C60-Pd)-PBT film features high specific capacitance.

Keywords:
carbon nanotubes, conducting polymer, composite, supercapacitor

Use:
Composites, Storing the electricity, Batteries and accumulators

State of the progress:
stage of research

Expected cooperation:
cooperation agreement – invention

Links to the publication:
- 1

OFFER no. 2/08

Title of the invention:
Molecularly imprinted polymer, method of its preparation, and piezoelectric chemical sensor for determination of biologically active substances, advantageously histamine, dopamine, and adenine

Inventors:
Chitta Raghu, Włodzimierz Kutner, Subramanian Suriyanarayanan, Agnieszka Pietrzyk, Francis D'Souza

Field:
Analytical chemistry
Chemistry new materials

Summary:
The invention involves a molecularly imprinted polymer, MIP, a method of its preparation and a piezomicrogravimetric chemosensor for detection and determination of biologically active substances, advantageously histamine, dopamine, and adenine, containing this polymer. This polymer was prepared by potentidynamic electropolymerization of the dedicated bithiophene functional monomers. This chemosensor contains a MIP film as its recognition unit, deposited on poly(bithiophene) barrier layer. In turn, this layer was deposited by potentiodynamic electropolymerization on Pt film electrode sputtered onto a quartz crystal resonator. Thickness shear mode bulk acoustic wave (10 MHz, AT cut) resonators of a quartz crystal microbalance (QCM) were used as piezoelectric transducers of the detection signal into the mass change signal.

Keywords:
adenine, histamine, dopamine, piezomicrogravimetric chemosensor, quartz crystal microbalance (QCM), molecularly imprinted polymer (MIP), flow-injection analysis (FIA)

Use:
Analytical chemistry, Biosensors, Clinical research, Biochemistry and biophysics, Cellular and molecular biology

State of the progress:
stage of development

Expected cooperation:
cooperation agreement – invention development

Links to the publications:
- 1
- 2
- 3