|Department of Physical Chemistry of Supramolecular Complexes|
Head of Department: Professor Włodzimierz Kutner
tel. + 48 (22) 343-3217
Research work being pursuit in the Department of Physical Chemistry of Supramolecular Complexes is concentrated mainly on the relationship between structure and selectivity of complex formation in various heteromolecular systems, where one of the components (host) displays the ability to bind in a selective and reversible manner a variety of molecular species (guest). Consequently, this property may conveniently be used in the processes of dynamic separation (chromatography, electrophoresis) and detection (sensors, selective electrodes, etc.) of molecular species. The department is composed of several laboratories specialized in: X-ray structural analysis, gas and liquid chromatography, electrophoresis, electrochemistry of sensors and chemically modified electrodes, as well as laboratories of thermodynamics and thermochemistry.|
Research is directed to molecular recognition phenomena, which is a starting point to design systems able for effective separation of mixtures, activation of selected chemical reactions and molecular transport. Both skeletal systems with internal cavities of molecular dimensions (organic zeolites, cyclodextrins, calixarenes and their derivatives) and systems formed in self-assembly processes (hydrates, including hydrophobic hydrates with dominating role of non-covalent bonding) are investigated.
Development of new methods for mixture separations on the basis of the mentioned above processes of molecular recognition in inclusion complexes are important specialty of the Department. Separation of enantiomers is the field where important part of the actual research projects is involved, especially characteristic is the possibility of separation by inclusion optically active compounds non possessing functional groups, and, due to that, especially difficult to separate. Analysis of enantiomeric composition of pharmaceuticals and their metabolites or natural taste-and-flavor substances or their synthetic substitutes is the example of applications of developed analytical methods.
Structural factors play important role in molecular inclusion processes, and , consequently, most of the investigated processes has to be based on detailed structural knowledge of each of the components and the complexes formed. Departmental laboratory of diffractometry is highly specialized in investigation supramolecular complexes, which by their nature are fragile to the environmental changes. As a consequence, most of the measurements must be provided in situ i.e. in mother solutions. Examples are organic zeolites and hydrophobic hydrates.
Analysis of energetic effects of complexation on supramolecular level is provided in the thermochemical group. Beyond the routine measurements characterizing the equilibrium states in sorption-desorption processes (enthalpy, entropy), the calorimetry group has expertise in thermokinetics of these processes. What is especially important, the kinetic information is obtained from standard calorimetric measurements and kinetic parameters of the process are defined by additional analysis of thermal effects measured during experiment using original procedures elaborated by the group members.
The Department has wide international collaboration and takes part in Center of Excellence TALES as the coordinator and general executor. We have excellent collaboration with research groups in Russia, Ukraine, Moldova, United Kingdom, Italy, France, Israel, Romania and Spain (in frames of common research programs) and many laboratories in the world on the basis of less regular but very effective collaboration agreements (e.g. Japan, Taiwan, Germany, USA).
- Zielenkiewicz W., Poznański J., Zielenkiewicz A. - Partial molar volumes of aqueous solutions of some halo and amino derivatives of uracil. J. Solution Chem. 29, 757-769, 2000.
- Suwińska K., Golankiewicz B., Zielenkiewicz W. - Water molecules in the crystal structure of tricyclic acyclovir. Acta Cryst. C57, 767-769, 2001.
- Samsonenko D.G., Lipkowski J., Gerasko O.A., Virovets A.V., Sokolov M.N., Fedin V.P., Platas J.G., Hernandez-Molina R., Mederos A. - Cucurbituril as a new macrocyclic ligand for complexation of lanthanide cations in aqueous solutions. Eur. J. Inorg. Chem., 2380-2388, 2002.
- Lin C.Z.J., Chui S.S.Y., Lo S.M.F., Shek F.L.Y., Wu M.M., Suwinska K., Lipkowski J., Williams I.D. - Physical stability vs. chemical lability in microporous metal coordination polymers: a comparison of [Cu(OH)(INA)](n) and [Cu(INA)(2)](n): INA=1,4-(NC5H4CO2). Chem. Commun., 1642-1643, 2002.
- Turner B., Shterenberg A., Kapon M., Botoshansky M.,Suwińska K., Eichen Y. - Self-assembled calixpyrrole capsules: solid-state encapsulation of different guests in preorganized calixpyrrole capsules. Chem. Commun., 726-727, 2002.
- Asztemborska M., Sybilska D., Nowakowski R., Perez G.- Chiral recognition ability of a-cyclodextrin with regard to some monoterpenoids under gas-liquid chromatographic conditions. J. Chromatogr. A, 1010, 233-242, 2003.
- Taraszewska J., Migut K., KoĽbiał M. - Complexation of flutamide by native and modified cyclodextrins. J. Phys. Org. Chem. 16, 121-126, 2003.
- Gregorowicz J. - Solubility of tetracosane in supercritical ethane and ethylene. J. of Supercritical Fluids 27, 13-23, 2003.
- Lewiński J., Marciniak W., Lipkowski J., Justyniak I. - New Insights into the reaction of zinc alkyls with dioxygen. J. Am. Chem Soc. 125, 12698-12699, 2003.
- Sherigara B.S., Kutner W., D'Souza F. - Electrocatalytic properties and sensor applications of fullerenes and carbon nanotubes. Electroanalysis 15, 753-772, 2003.
- Grolier J.-P.E., Dan F., Boyer S.A.E., Orlowska M., Randzio S.L. - The use of scanning transitiometry to investigate thermodynamic properties of polymeric systems over extended T and p ranges. Int. J. Thermophys. 25, 297-319, 2004.
- Poznański J., Wszelaka-Rylik M., Zielenkiewicz W. - Concentration dependencies of NaCl salting of lysozyme by calorimetric methods. Thermochim. Acta 409, 25-32, 2004.
- Godsi O., Turner B., Suwińska K., Peskin U., Eichen Y. - Enol-enamine tautomerism in crystals of 1,3-bis(pyridin-2-yl) propan-2-one: a combined crystallographic and quantum-chemical investigation of the effect of packing on tautomerization processes. J.Am.Chem.Soc. 126, 13519-13525, 2004.
- Grigoriew H., Luboradzki R., Cunis S. - In situ studies of monosaccharide gelation using the small-angle X-ray scattering time-resolved method. Langmuir 20, 7374-7377, 2004.
- Marinescu G. , Visinescu D. , Cucos A. , Andruh M. , Journaux Y., Kravtsov V. , Simonov Yu., Lipkowski J. - Oxalato-Bridged [CuIICrIII] and [MnIICrIII] Binuclear Complexes Synthesis, Crystal Structures, Magnetic and EPR Investigations. Eur. J. Inorg. Chem. 2914-2922, 2004.
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